Protein Alignment Mrp4 and mrp-7

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_507812.3
• Gene: mrp-7 / 180289
• WormBaseID: WBGene00003413
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1369
• Identity: 474/1369 - (34%)
• Similarity: 745/1369 - (54%)
• Gaps: 142/1369 - (10%)

  Fly    12 NPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK--NET 74
            :|..:||.|:.|...:...:.:.|.::.||..|::...:...::.|.:...:.|:.:..|  ::|
 Worm   207 SPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTEFLSELWESFWEPKRLKYIHDT 271

  Fly    75 ------------------PRLGRALTKVFGFHLFITGVFLLAQ--EFLTKVTQ---PICLIGVMA 116
                              |.:..:|..:|.:.      ||||.  :|::...|   |..|..::.
 Worm   272 SIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWE------FLLASTLKFVSDTMQFASPFLLHELLN 330

  Fly   117 YFAGNDPDRSKAQLWAAGLIAGSVFSV-----CIGHPYMLGLLHLGMKMRIALSSLIYRKALRLS 176
            :.:..:     |..|....::..:|||     .|.:.|...:..:|.|::.:|::.:|:|.|.:|
 Worm   331 FISAKN-----APFWKGMALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLLIS 390

  Fly   177 RTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLF 241
            .:|..|.|||::|||::.||.||.::...:...|..|.::......:::.:|.|::.||.||::|
 Worm   391 NSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIF 455

  Fly   242 LP---FQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLC 303
            :|   ..|.:.::..:.:::.   .|||.:|:||:::||:|:|:||||.|....::..|..|:..
 Worm   456 VPMNIISSMIVRKWQIEQMKL---KDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELAL 517

  Fly   304 IKQVNYIRGILISF---AMFLSRIFTSSSLIAFVLL--GNILNAEKAFFVTAYYNILRRSVTMFF 363
            ||:...:|.||.||   :.||..:|   |...|||.  .::|..:.||...|.:|.||..:|| .
 Worm   518 IKKSAMVRNILDSFNTASPFLVALF---SFGTFVLSNPSHLLTPQIAFVSLALFNQLRSPMTM-I 578

  Fly   364 PQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQ 428
            ...|::..:.:||.:||:.|:...|...:...:..|..:.               .|.:......
 Worm   579 ALLINQAVQAVVSNKRLKEFLVAEELDEKCVDRSVNIERS---------------HNAVRVENLT 628

  Fly   429 ARW--ESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAA 491
            |.|  |..:.|.||:|::|...|..|:||:|.||:|||||:||:|||:....|.:.:||..:|..
 Worm   629 ASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVNGRVAYVP 693

  Fly   492 QEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARIS 556
            |:||:...|:|.||.||..:|:.||..|:..|||:.|.::||.||:|.:||:|.:||||||||:|
 Worm   694 QQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSGGQKARVS 758

  Fly   557 LARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLEQADLIVIMD 619
            ||||||:..|:|||||||||||.|||||:|::.:  .|.||.:..|||||.|.:.:.||.|::|.
 Worm   759 LARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMADEILVML 823

  Fly   620 KGRISAMGTYSSM-KRSGL--DFAQLLTAPNKDAEDL-----DEIDGAGGDGLDLLN-------- 668
            :|:|...||:..: ||.||  ||.:...:.:.::.:.     |:.:..||:..|.:|
 Worm   824 EGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNPEDVVLTV 888

  Fly   669 ---------VPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEY 724
                     .|.|:.:.|..|.|. :..:.||.::..||   :..|..:|...:||:.:..|:.|
 Worm   889 TNDLDETIRTPELTTQISTMSSPE-KPPTGTSPAAATES---QNKLIKKEGIAQGKVEIATYQLY 949

  Fly   725 LTSG----SSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQD---------- 775
            :.:.    |..|:.||:|::.|  |||.|   ::||.|.|:         .||..
 Worm   950 VKAAGYLLSIAFIGFFIVYMTL--QILRS---FWLSAWSDE---------YDPDSPSAHPMAKGW 1000

  Fly   776 -MYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKD 839
             :..:.||..:......|..:....:..|:|..||..:...:.|:.|.|::|.|.||||||.:||
 Worm  1001 RLGVYGALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKD 1065

  Fly   840 LGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLE 904
            :..:|.:||.....:|...|.:...::||.|:.|.:.::.|.||:|:.....:|:.|||.:||||
 Worm  1066 IETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLE 1130

  Fly   905 AVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLD----C 965
            :|.|||||||...||.|..:|||.|...|...:...:.|......|:.|.:||.....|:    |
 Worm  1131 SVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNRWLAVRLEFVGNC 1195

  Fly   966 FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIE 1030
            ......:..:|:.......|||.:|::::.|:.:|.::.:|:||.:|:|..:.:||||.||....
 Worm  1196 IIFFAALFAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSEIEANIVSVERVNEYTNTP 1260

  Fly  1031 PEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGK 1095
            .|..: ..||::|:|.||.:|.:..:....||  ......||..::..:...||:||||||||||
 Worm  1261 NEAPW-RIEGREPAPGWPSRGVVKFDGYSTRY--REGLDLVLHDISADVAAGEKIGIVGRTGAGK 1322

  Fly  1096 SSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAK 1159
            ||...|||| :....|.|.||:.:.:.:||.||||.|:||||:||||||::|:|||||..|:|.:
 Worm  1323 SSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQ 1387

  Fly  1160 LWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQ 1224
            :|.|||...||...:.||:||..||||.|.|.||||||||.||||:||..||||:|||||.||..
 Worm  1388 IWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVA 1452

  Fly  1225 TDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVM 1289
            ||||||.|||.:|::|||.|||||||||||.||::|:|.|.::||.:| :.|.:.::..|..||.
 Worm  1453 TDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTP-DALMADKNSAFAKMVA 1516

  Fly  1290 ETGQ 1293
            :..:
 Worm  1517 DAAE 1520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	474/1365 (35%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	474/1365 (35%)