Protein Alignment Mrp4 and Abcc1

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_032602.1
• Gene: Abcc1 / 17250
• MGIID: 102676
• Length: 1528
• Species: Mus musculus
• Alignment Length: 1388
• Identity: 495/1388 - (35%)
• Similarity: 747/1388 - (53%)
• Gaps: 178/1388 - (12%)

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW------------ 65
            |...:|.||.:.|.:...::..|.::.||..||:...||..|:.:...|...|
Mouse   209 PESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPV 273

  Fly    66 ---------------------DEQVA--------KNETPRLGRALTKVFGFHLFITGVFLLAQEF 101
                                 :|:|.        |:..|.|.:.|.|.||.:      ||::  |
Mouse   274 RIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPY------FLMS--F 330

  Fly   102 LTKVTQPICLIGVMAYFAG-----------ND---PDRSKAQLWAAGLIAGSVF-SVCIG----H 147
            |.|....:.:      |||           ||   ||      |........:| |.|:.    |
Mouse   331 LYKALHDLMM------FAGPKILELIINFVNDREAPD------WQGYFYTALLFVSACLQTLALH 383

  Fly   148 PYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIA 212
            .|.......||:::.|:...:|||||.::..|...:|||::|||:|.|..||..:...::.:|.|
Mouse   384 QYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 448

  Fly   213 PLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGI 277
            ||::|...|.::|.:|.|.:.|||:|:|.:|..:.:..:|...::......|.|:::||||::||
Mouse   449 PLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGI 513

  Fly   278 QVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGI-------------LISFAMFLSRIFTSSS 329
            :|:|:||||..|...|...|..|:..:|:..|:..:             |.:||:|::
Mouse   514 KVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT------- 571

  Fly   330 LIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDK 394
                |...|||:|:|||...|.:||||..:.: .|..||...:..||::||..|:...|.   :.
Mouse   572 ----VDERNILDAKKAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEEL---EP 628

  Fly   395 SKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPV 459
            ..::..:.|       |.:||.|......|:  .||.|    .|||..|...:....||||:|.|
Mouse   629 DSIERRSIK-------SGEGNSITVKNATFT--WARGE----PPTLNGITFSIPEGALVAVVGQV 680

  Fly   460 GAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCA 524
            |.|||||:.|:|.|:....|.:.:.||.:|..|:.|:...::|:|||||....::.|:.|::.||
Mouse   681 GCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACA 745

  Fly   525 LERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQC 589
            |..|.|:||.||:|.:||:|.:||||||.|:|||||||..:||||.||||||||.|||:|:|::.
Mouse   746 LLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKV 810

  Fly   590 M--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSS-MKRSGLDFAQLL-TAPNKDA 650
            :  .|.|:::..|||||.:.:|.|.|:|::|..|:||.||:|.. :.|.|. ||:.| |..|.:.
Mouse   811 VGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGA-FAEFLRTYANAEQ 874

  Fly   651 EDLDEIDGAGGDGLDLLNVPS-----------LSRRGSKNSKPS-TRNNSFTSLSSMAESMAQEA 703
            :...|.|...|.|.:...|.:           |.|..|.:|..| ..:...:|::.:.::.|:|.
Mouse   875 DLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEE 939

  Fly   704 SLQMQET--RVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKN--VD 764
            :.::.|.  ...|::.|.:|..|: .....|:.|..:||.|...:...|::|:||.|.|..  |:
Mouse   940 TWKLMEADKAQTGQVQLSVYWNYM-KAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVN 1003

  Fly   765 GQTDINTDPQDMYYFAALNV--AVVVFTIVRTMLFYKMAMR-----SSTQLHNAMYQGITRAAMY 822
            | |..|.:.: :..:.||.:  ...:|.       |.||:.     :|.:||..:...:.|:.|.
Mouse  1004 G-TQANRNFR-LSVYGALGILQGAAIFG-------YSMAVSIGGIFASRRLHLDLLYNVLRSPMS 1059

  Fly   823 FFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFY 887
            ||...|||.::|||||:|..:|.::|.|:...:....:::|.:::|.:..|...::...|.::::
Mouse  1060 FFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYF 1124

  Fly   888 YIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTF 952
            :::.||:.:||.:||||:|:|||:|||.:.|:.|:..|||...|:..|.:.|...|.:...||..
Mouse  1125 FVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1189

  Fly   953 LATNRAFGYYLDC-------FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQS 1010
            :..||.....|:|       |..|:.||      .....|.|.|||:::.::.:|..:.|.:|.|
Mouse  1190 IVANRWLAVRLECVGNCIVLFAALFAVI------SRHSLSAGLVGLSVSYSLQITAYLNWLVRMS 1248

  Fly  1011 AELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKAL 1075
            :|:|..:.||||:.||.|.|.|..:..:|...|| :||..|.:...|.||||..|  ...|||.:
Mouse  1249 SEMETNIVAVERLKEYSETEKEAPWQIQETAPPS-TWPHSGRVEFRDYCLRYRED--LDLVLKHI 1310

  Fly  1076 NFRIRPCEKVGIVGRTGAGKSSLINALFRLSYN-EGIITIDERDTADMGLFDLRSKISIIPQEPV 1139
            |..|...||||||||||||||||...|||::.: ||.|.||..:.|.:||.:||.||:||||:||
Mouse  1311 NVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPV 1375

  Fly  1140 LFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARA 1204
            |||||:|.|||||.:|:|.::|.|||...||..:|.||:.|..:.:|||.|.|||||||||||||
Mouse  1376 LFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARA 1440

  Fly  1205 ILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEF 1269
            :||:.::||:|||||.||.:||.|||:|||::|.||||||||||||||||..||:|:|.|.:.|.
Mouse  1441 LLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVREC 1505

  Fly  1270 GSPYELLTSSESKIFHGMVMETG 1292
            |:|.|||  .:..||:.|..:.|
Mouse  1506 GAPSELL--QQRGIFYSMAKDAG 1526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	494/1386 (36%)
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	495/1388 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	876..895		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	909..929		5/19 (26%)