Protein Alignment Mrp4 and Abcc4

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_038948894.1
• Gene: Abcc4 / 170924
• RGDID: 620266
• Length: 1382
• Species: Rattus norvegicus
• Alignment Length: 1404
• Identity: 589/1404 - (41%)
• Similarity: 844/1404 - (60%)
• Gaps: 153/1404 - (10%)

  Fly     8 ELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQV--A 70
            |:..||.:.::..|.|.|.:..|:...|.|:.||:.|::..|.|.:|..||:.|...||::|  |
  Rat     7 EVKPNPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRA 71

  Fly    71 KNET--PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAA 133
            |.:.  |.|.:|:.|.:.....|.|:|.|.:| .|:|.|||.|..::.||...|.|.|.|...|.
  Rat    72 KKDARKPSLTKAIVKCYWKSYLILGIFTLIEE-TTRVVQPIFLGKIIDYFEKYDSDDSAALHTAY 135

  Fly   134 GLIAGSVFSVC------IGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLL 192
            |..|  |.|:|      :.|.|...:...||::|:|:..:|||||||||.:|:|.||.||:||||
  Rat   136 GYAA--VLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLL 198

  Fly   193 SNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRL 257
            ||||.:||.|.|.:|:||..||:.|.||.|:::|||||.:.|:||:::.||.||.:||..|.||.
  Rat   199 SNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRS 263

  Fly   258 RTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLS 322
            :||..||.|:|.|||:|:|:::||||||||.|..::...|..|:..|...:|:||:.::.....:
  Rat   264 KTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMASFFIAN 328

  Fly   323 RIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRP 387
            ::....:...:|||||.:.|...|.....|..:|.:||:|||..|...:|.:|||||::.|:...
  Rat   329 KVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLD 393

  Fly   388 ETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKL 452
            |...|          ||:.|:    .|..|    :....|.|.|:.....|||:.::......:|
  Rat   394 ELPER----------KAQEPS----DGKAI----VHVQDFTAFWDKALDTPTLQGLSFTARPGEL 440

  Fly   453 VAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYR 517
            :||:||||||||||:.|:|||||..||.:.::|..:|.:|:||:|:||||.|||||..::|.||.
  Rat   441 LAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYE 505

  Fly   518 TVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVG 582
            .|:|.|||::|.:||..||.|::|:|||:||||||||::||||||:.||||||||||||||..||
  Rat   506 KVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVG 570

  Fly   583 RHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPN 647
            :|||..|:...|..::.||||||||:|:.|..|:|:..|.:...|||:...:||:||..||...|
  Rat   571 KHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKEN 635

  Fly   648 KDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESM-----------AQ 701
            ::||...              ||         ..|:.||.:|:..|..::..           ||
  Rat   636 EEAEPSP--------------VP---------GTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQ 677

  Fly   702 EA----SLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDK- 761
            :|    :.|.:|:|.||:||...||.|.::|:|||.|.|:|.|.|..|:.....|::||:|.::
  Rat   678 DAENTQAAQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQ 742

  Fly   762 -----------NVDGQTDINTDPQDMYY---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAM 812
                       ||.|..|::      :|   :..|....|:|.|.|::|.:.:.:.:|..|||.|
  Rat   743 GALNDTKNANGNVTGTLDLS------WYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRM 801

  Fly   813 YQGITRAAMYFFNTNP------------------------------------------------- 828
            ::.|.:|.:.||:.||
  Rat   802 FESILKAPVLFFDRNPIELTQLEVFRVVDGALDSHRHLSHPHPWPQNGSLQASVTSVTGSDVIRF 866

  Fly   829 --------SGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAII 885
                    .||||||||||:|.:|::||...||.:|..|.::.:|.|.....|:.||..:.|:||
  Rat   867 PEVLLLALPGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSII 931

  Fly   886 FYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYY 950
            |..:|.::|:|||||||||:..|||::||||:::.||.||||..|::.....||..|||||..::
  Rat   932 FVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWF 996

  Fly   951 TFLATNRAFGYYLDCFCTLYIVIIIL-NYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELE 1014
            .||.|:|.|...||..|.::::::.. :..:......|:||||::.::.:.||.||::|||||:|
  Rat   997 LFLTTSRWFAVRLDAICAVFVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVE 1061

  Fly  1015 NTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRI 1079
            |.|.:||||:||.::|.|..::.|  |:|.|.||.:|.|:.:::...|..|  ...|||.|...|
  Rat  1062 NMMISVERVIEYTDLEKEAPWECR--KRPPPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTALI 1122

  Fly  1080 RPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGS 1144
            :..|||||||||||||||||:||||||..||.|.||:..|.::||.|||.|:||||||||||:|:
  Rat  1123 KSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGT 1187

  Fly  1145 MRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILREN 1209
            ||.|||||.|::|.:||.|||||:||..|.:||..:.::::|.|||||||||||||||||||::|
  Rat  1188 MRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKN 1252

  Fly  1210 RVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYE 1274
            |:|::|||||||||:||.|||..||.||..|||||||||||||:|||:::|:|:|.|.|:..||.
  Rat  1253 RILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYV 1317

  Fly  1275 LLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKP 1313
            ||.:.|| :|:.||.:.|:....:|.:.|::.:.....|
  Rat  1318 LLQNPES-LFYKMVQQLGKGEAAALTETAKQVYFRRNYP 1355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	583/1376 (42%)
Abcc4	XP_038948894.1	MRP_assoc_pro	6..1334	CDD:188098	585/1381 (42%)