Protein Alignment Mrp4 and ABCC4

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_005836.2
• Gene: ABCC4 / 10257
• HGNCID: 55
• Length: 1325
• Species: Homo sapiens
• Alignment Length: 1344
• Identity: 582/1344 - (43%)
• Similarity: 847/1344 - (63%)
• Gaps: 90/1344 - (6%)

  Fly     8 ELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKN 72
            |:..||.:.::..|.:.|.:..|:...|.|:.||:.|:|..|.|.:|..||:.|...||::|.:.
Human     7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71

  Fly    73 ET----PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRS----KAQ 129
            |.    |.|.||:.|.:.....:.|:|.|.:| ..||.|||.|..::.||...||..|    .|.
Human    72 ENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEE-SAKVIQPIFLGKIINYFENYDPMDSVALNTAY 135

  Fly   130 LWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSN 194
            .:|..|...::....:.|.|...:...||::|:|:..:|||||||||..|:|.||.||:||||||
Human   136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSN 200

  Fly   195 DVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRT 259
            ||.:||.|.:.:|:||..||:.||||.|:::|||||.:.|:|::::.||.||..||..|.||.:|
Human   201 DVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKT 265

  Fly   260 ALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRI 324
            |..||.|:|.|||:|:||::||||||||.|..::...|..|:..|.:.:.:||      |.|:..
Human   266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRG------MNLASF 324

  Fly   325 FTSSSLIAF------VLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAF 383
            |::|.:|.|      ||||:::.|.:.|.....|..:|.:||:|||..|...:|.:||:||::.|
Human   325 FSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTF 389

  Fly   384 MHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLG 448
            :...|...|::          :.|: |..|       ::....|.|.|:..|..|||:.::..:.
Human   390 LLLDEISQRNR----------QLPS-DGKK-------MVHVQDFTAFWDKASETPTLQGLSFTVR 436

  Fly   449 RRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDK 513
            ..:|:||:||||||||||:.|:||||....|.:.::|..:|.:|:||:|:||:|.|||||..::|
Human   437 PGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEK 501

  Fly   514 HRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVD 578
            .||..|:|.|||::|.:||..||.|::|:||.:||||||||::||||||:.||||||||||||||
Human   502 ERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566

  Fly   579 THVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLL 643
            ..|.||||:.|:...|..::.||||||||:|:.|..|:|:..|::...|||:...:||:||..||
Human   567 AEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631

  Fly   644 TAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRR--------GSKNSKPSTRNNSFTSLSSMAESMA 700
            ...|:::|. ..:.|          .|:|..|        ..::|:||.::.:..|..:  |::.
Human   632 KKDNEESEQ-PPVPG----------TPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT--ENVP 683

  Fly   701 QEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDK---- 761
            ...|   :|.|.|||:|...||.|..:|:.|.:..|::.|..|.|:.....|::||||.:|
Human   684 VTLS---EENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSML 745

  Fly   762 --------NVDGQTDINTDPQDMYY---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQG 815
                    ||..:.|:|      :|   ::.|.||.|:|.|.|::|.:.:.:.||..|||.|::.
Human   746 NVTVNGGGNVTEKLDLN------WYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFES 804

  Fly   816 ITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTL 880
            |.:|.:.||:.||.||||||||||:|.||::||...||.:|..|.::|::.|.....|:..|..:
Human   805 ILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLV 869

  Fly   881 ALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLH 945
            .|.|||.::|.::|:|||||||||:..|||::||||:::.||.||||..|::.....||..||||
Human   870 PLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLH 934

  Fly   946 SSGYYTFLATNRAFGYYLDCFCTLYIVIIIL-NYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQ 1009
            |..::.||.|:|.|...||..|.::::|:.. :..:......|:||||::.|:.:.||.||.:||
Human   935 SEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQ 999

  Fly  1010 SAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKA 1074
            |||:||.|.:||||:||.::|.|..::.:  |:|.|:||.:|.||.:::...|  .|....|||.
Human  1000 SAEVENMMISVERVIEYTDLEKEAPWEYQ--KRPPPAWPHEGVIIFDNVNFMY--SPGGPLVLKH 1060

  Fly  1075 LNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPV 1139
            |...|:..|||||||||||||||||:||||||..||.|.||:..|.::||.|||.|:||||||||
Human  1061 LTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPV 1125

  Fly  1140 LFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARA 1204
            ||:|:||.|||||.|:.|.:||:||:||:||..|.:||..:.::::|.|||||||||||||||||
Human  1126 LFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARA 1190

  Fly  1205 ILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEF 1269
            |||:|::|::|||||||||:||.|||..||.||..|||||||||||||:|||:::|:|:|.|.|:
Human  1191 ILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEY 1255

  Fly  1270 GSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKP 1313
            ..||.||.:.|| :|:.||.:.|:....:|.:.|::.:.:...|
Human  1256 DEPYVLLQNKES-LFYKMVQQLGKAEAAALTETAKQVYFKRNYP 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	576/1316 (44%)
ABCC4	NP_005836.2	PLN03130	12..1277	CDD:215595	576/1316 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..688		6/35 (17%)
		PDZ-binding	1322..1325