Protein Alignment Mrp4 and ABCC9

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_005682.2
• Gene: ABCC9 / 10060
• HGNCID: 60
• Length: 1549
• Species: Homo sapiens
• Alignment Length: 1397
• Identity: 435/1397 - (31%)
• Similarity: 697/1397 - (49%)
• Gaps: 200/1397 - (14%)

  Fly    20 LSSLMFCFALPVLFKGRKKTLEQKDL------------YRALKEHKSDSLGDRLCAAWDEQVAK- 71
            ||...:.:...::....||.::.|.:            |..||:            |::||..|
Human   223 LSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKD------------AYEEQKKKV 275

  Fly    72 ----NETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDR------- 125
                |.||.:..|:.:.||..:.::..|....:.| ....|:|:.|::...  |:...
Human   276 ADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLL-GFAGPLCISGIVQRV--NETQNGTNNTTG 337

  Fly   126 ------SKAQLWAAGLIAGSVFSVCIGHPYMLG-----LLHLGMKMRIALSSLIYRKALRLSRT- 178
                  ||..|..|.::|..:|...|.....|.     .:..|:.:|.||.::||.|.||||.:
Human   338 ISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSN 402

  Fly   179 -ALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFL 242
             ::|:.|:||:.||::.:..:....|.....||..|:::|....|:|..:|.|::.|.|:::|..
Human   403 LSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLA 467

  Fly   243 PFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQV 307
            |.|.::..:.:..:..|...:.||::..|||:.||:::|:||||..|.|.||.||..|:..:|
Human   468 PIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK-- 530

  Fly   308 NYIRGILISFAMFLS-RIFTSSSL-IAFVLL---------GNILNAEKAFFVTAYYNILRRSVT- 360
                    :||::.| .||.:::: ||.||.         ||.|...:||...:.::||   ||
Human   531 --------TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL---VTP 584

  Fly   361 MFFPQGISEFA-ELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAES--PNGDSPKGNGIPENLI 422
            :|....:..|| :.::||::|..|:...|  :.|.|.     :..||  |.....|..|:....|
Human   585 LFLLSTVVRFAVKAIISVQKLNEFLLSDE--IGDDSW-----RTGESSLPFESCKKHTGVQPKTI 642

  Fly   423 EFSQFQARWESHSLE-----------------------------PTLEDINLQLGRRKLVAVIGP 458
            ...| ..|:...|.|                             .||.:|::::...:|..::|.
Human   643 NRKQ-PGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQ 706

  Fly   459 VGAGKSSLIQAILGELPGESGTL---------------RINGSYS--YAAQEPWLFTGTVRQNIL 506
            ||.|||||:.|||||:....|.:               |....||  ||||:|||...||.:||.
Human   707 VGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 771

  Fly   507 FGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLD 571
            ||..::|.||:.|...|:|:.|.:||||||:|.:||||.:|||||:.||.:|||:|:..:|..||
Human   772 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLD 836

  Fly   572 DPLSAVDTHVGRHLFDQCMRGYLRSE--LVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKR 634
            ||.||:|.|:..||..:.:..:|:.:  .::||||:||:|..||.|:.|..|.:...||...::.
Human   837 DPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQT 901

  Fly   635 SGLD-FAQLLTAPNKDAEDLDEIDGAGGDGLDL-LNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE 697
            ..:: :....|..|:..::|::         |: .:..:|.|:..:.:..|
Human   902 KDVELYEHWKTLMNRQDQELEK---------DMEADQTTLERKTLRRAMYS-------------- 943

  Fly   698 SMAQEASLQMQE------------------TRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLAT 744
               :||..||::                  .|:..|:.......||||| .:|::..|:|..|..
Human   944 ---REAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSG-GFFLLILMIFSKLLK 1004

  Fly   745 QILCSAADYFLSYWVDK---NVDGQTDINTDPQDMYYFAALNV---AVVVFTIVRTMLFYKMAMR 803
            ..:..|.||:|:.|..:   |..|:.|      ..||.|..::   |.:...:|.::....|.:.
Human  1005 HSVIVAIDYWLATWTSEYSINNTGKAD------QTYYVAGFSILCGAGIFLCLVTSLTVEWMGLT 1063

  Fly   804 SSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVI 868
            ::..||:.:...|....:.||:|.|.|.||||||.|...:|:.:|..:..:.:..|..|..|.:|
Human  1064 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMI 1128

  Fly   869 CITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKE 933
            ....|.:|:..|.|.:.||:|::::...|:|::.|:...:.|:..|.|.|..||.||||...:..
Human  1129 SYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETR 1193

  Fly   934 LIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMG 998
            .......|.|.::..|....|.||......| :....||:......|:...:.|.|||.:..|:.
Human  1194 FKQRMLELTDTNNIAYLFLSAANRWLEVRTD-YLGACIVLTASIASISGSSNSGLVGLGLLYALT 1257

  Fly   999 MTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYF 1063
            :|..:.|.:|..|:||..|.||::|..:..:|.|....:.:..:....||::|||...|||:||
Human  1258 ITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRY- 1321

  Fly  1064 PDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDL 1127
             :...|.|||.:...|:|.:||||.||||:|||||..|.||: ...:|.|.||..|.:.:.|..|
Human  1322 -ENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTL 1385

  Fly  1128 RSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFS 1192
            ||::|||.|:|:|||||:|:||||..:..|.:||:|||..:||.::..||.||.:.::|||.|||
Human  1386 RSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFS 1450

  Fly  1193 VGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDR 1257
            ||||||.|||||.:|::.:|:||||||::|..|:.::|..:.:.|.|.||:|||||:::|||:..
Human  1451 VGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGL 1515

  Fly  1258 VLVMDAGHLVEFGSPYELLTSSESKIFHGMVM 1289
            |||...|.|||..:...|| :.::.:|..:||
Human  1516 VLVFSEGILVECDTVPNLL-AHKNGLFSTLVM 1546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	435/1397 (31%)
ABCC9	NP_005682.2	MRP_assoc_pro	222..1541	CDD:188098	432/1390 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	944..967		4/22 (18%)