Protein Alignment Mrp4 and abcc2

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_004915926.1
• Gene: abcc2 / 100485020
• XenbaseID: XB-GENE-1012796
• Length: 1552
• Species: Xenopus tropicalis
• Alignment Length: 1413
• Identity: 501/1413 - (35%)
• Similarity: 760/1413 - (53%)
• Gaps: 169/1413 - (11%)

  Fly     3 SMKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSL---------G 58
            |.|.:...|||...:|.||.:.|.:...::.||.||.||.:||:...:|.|:.::         .
 Frog   193 SEKNESTKENPELTASFLSRITFNWYNSIVVKGYKKPLEMEDLWELNEEDKTKNMYEIFEKHMKH 257

  Fly    59 DRLCAAWDEQVAKNETPR----------------------------------------------L 77
            |...|..|.:..||:..:                                              |
 Frog   258 DVRKAKKDLEKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTAKDYPKRWL 322

  Fly    78 GRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQ--LWAAGLIAGSV 140
            .:.|.|.|...|..:.:|.|..:.|..|:..|  :.||..|.. ||.:.:.|  .:|..|:..::
 Frog   323 IKTLIKTFPSTLLTSAIFKLLHDLLAFVSPQI--LKVMVTFTA-DPSQHQWQGFFYAVLLLVTAL 384

  Fly   141 FSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLIN 205
            ....:...|..|...|||::|..|.:.:|:|||.:|.....::|||:.|||:|.|..|| :.|.|
 Frog   385 LQSFLLQQYFHGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVNLMSADAQRF-MDLTN 448

  Fly   206 -VHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRM 269
             :|.||.:||::......::.|:|.|.:.|:.:|:|.:|..:.|...:..|:::.....|:|:::
 Frog   449 FIHLLWSSPLQIAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKRMKI 513

  Fly   270 MNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGI---LISFAMFLSRIFTSSSLI 331
            ||||::||:::|:||||..|...|:..|..|:..:....|:..:   :.:.|.||..:.|.:..:
 Frog   514 MNEILNGIKILKLYAWEPSFENQVQEIREKELKDMLHFTYLHSVSLFVFTCAPFLVSVATFAVYV 578

  Fly   332 AFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSK 396
            | |...|:|||||||...:.:||||..:.| .|..||...:..||..|||.::.....   |.|.
 Frog   579 A-VDPSNVLNAEKAFTSISLFNILRFPLAM-LPMLISSMVQTSVSSARLEKYLGGDNL---DTSA 638

  Fly   397 VKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGA 461
            ::.      .||.|:         .::||.....||..: .|.:.::||.:....||||:|.||:
 Frog   639 IRC------DPNIDA---------AVQFSDATFSWEEDA-NPAVNNVNLDIKEGNLVAVVGGVGS 687

  Fly   462 GKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALE 526
            |||||:.|:|||:....|.:.|.||.:|..|:.|:...|::.|||||...|:.||:.|::.|||.
 Frog   688 GKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNNILFGSKMDEERYQKVLEACALL 752

  Fly   527 RDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM- 590
            .|.|:||..|::.:||:|.:||||||.|:|||||||..||||:|||||||||.|||:|:|::.:
 Frog   753 PDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYILDDPLSAVDAHVGKHIFEKVVG 817

  Fly   591 -RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLD 654
             .|.|:::..|||||.:.||:.||.||::...|::..|:|.:::.:...||:.|....|..:..|
 Frog   818 PNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTLQANNGAFAEFLRLYAKQNDQTD 882

  Fly   655 --------EIDGAGGDGLDLLNV------PSLSRRGS-KNSKPSTRNNSFTSLSSMAESMAQEAS 704
                    |.|...||.::...|      .::.|..| :..|.|:.:.:.|...|:.:...::..
 Frog   883 NEATVFTGEDDEDDGDQVETAEVIEDIVASTVKRENSMRQRKRSSVSMNGTLRRSVKDVTKKKTG 947

  Fly   705 LQMQETR---------VE-GKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA----DYFL 755
            :...:|:         || ||:...||.:||.: ..|...|::    ..:.||.:||    :.:|
 Frog   948 IGSNDTKGQKLIEKETVETGKVKFKLYLKYLRA-VGWGFSFWI----FVSYILQNAAFVGQNIWL 1007

  Fly   756 SYWVDKNVDGQTDINTDPQDMYY---------------FAALNVAVVVFTIVRTMLFYKMAMRSS 805
            |.|            |...:.||               |.||.||..:|.::...|....|:|:|
 Frog  1008 SDW------------TGDAEKYYNITYPASQRDMRVGVFGALGVAQALFVLLGAFLVSGGAVRAS 1060

  Fly   806 TQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICI 870
            ..||..:...|.|..|.||:|.|:|||:|||:||:..:||.:|......:..||.::|.:.:||:
 Frog  1061 RMLHTQLLHNILRVPMRFFDTTPTGRIVNRFAKDILTVDETIPMSFRSWIACFLGVIGTLFIICL 1125

  Fly   871 TNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELI 935
            ..|.:..:.:.|||.:|:::.||:.|||.::||::|.|||||||...|::||..|||.|.|...:
 Frog  1126 ATPIFAAVIVPLAIFYYFVQRFYVTTSRQLRRLDSVTRSPIYSHFGETVSGLSVIRAYGHQDRFL 1190

  Fly   936 AEFDNLQDLHSSGYYTFLATNRAFGYYLD-------CFCTLYIVIIILNYFINPPQSPGEVGLAI 993
            ...::..|.:....|:::.:||.....|:       .|..|:.|:      .......|.|||:|
 Frog  1191 QHNEDTIDNNQKSVYSWIVSNRWLAIRLEFVGNLTVFFAALFAVL------GRGTVDSGTVGLSI 1249

  Fly   994 TQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDL 1058
            :.|:.:|..:.|.:|.::|||..:.|||||.||.::|.|.::  .|..:|...|||||.:...|.
 Frog  1250 SSALNITQTLNWLVRMTSELETNIVAVERVDEYIKVEREAQW--VEDHRPPKDWPEKGVVQFVDY 1312

  Fly  1059 CLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNE-GIITIDERDTADM 1122
            .:||  .|:...||:.::..|...||||||||||||||||.|.:||:..:. |.|.||..|.|.:
 Frog  1313 KVRY--RPELDLVLQGISCTINSMEKVGIVGRTGAGKSSLTNCIFRIIESAGGKIMIDGLDIASI 1375

  Fly  1123 GLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEG 1187
            ||.|||.|::||||:||||||::|.|||||.:|.|..:|.|||...|||.:..|...|..::|||
 Frog  1376 GLHDLRQKLTIIPQDPVLFSGNLRMNLDPFNQYTDEDIWKALELSHLKPFVEGLQEKLFHEVSEG 1440

  Fly  1188 GSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTI 1252
            |.|.|||||||||||||:||::::|::|||||.||.:||.|||.||||:|.|||||||||||:||
 Frog  1441 GENLSVGQRQLVCLARALLRKSKILILDEATAAVDLETDNLIQRTIRSEFADCTVLTIAHRLHTI 1505

  Fly  1253 MDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDSLL 1300
            |||.|::|:|||.::|||||.|||  .....|..|..:.|.::..|.:
 Frog  1506 MDSSRLMVLDAGKIIEFGSPDELL--QRQGHFFSMAKDAGIDSTQSTI 1551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	495/1393 (36%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	499/1404 (36%)