Protein Alignment Mrp4 and abcc8b

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_068071075.1
• Gene: abcc8b / 100329706
• ZFINID: ZDB-GENE-120215-45
• Length: 1608
• Species: Danio rerio
• Alignment Length: 1410
• Identity: 427/1410 - (30%)
• Similarity: 689/1410 - (48%)
• Gaps: 186/1410 - (13%)

  Fly    20 LSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNETPRLG-----R 79
            ||...:.:....:....::.::.|.:.:..|..::.|...:|..|:|.|:........|     |
Zfish   240 LSKSTYWWMNTFITSAHQRPIDLKTIGKLPKSMRALSNFQQLRKAFDSQMESGCVHLQGSGWMWR 304

  Fly    80 ALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFA-GNDPDRSKAQLWAAGLIAGSVFSV 143
            ||.:.||..|.::..|....:.| ....|:|:.|::.:.: .|.......:|.....|:..||
Zfish   305 ALRQAFGAPLLLSICFRFISDLL-GFAGPLCISGILQHISRDNHTAPPPVKLLGVHFISSEVF-- 366

  Fly   144 CIGHPYMLGLL--------------------HLGMKMRIALSSLIYRKALRL--SRTALGDTTVG 186
             ..:.|:|.:|                    ..|:.:|.|:.:.||.|.:||  |..::||.|..
Zfish   367 -FANAYVLAVLLFLALLLQRTFLQASYYVAIENGINLRGAVQTKIYNKIMRLCTSNMSMGDMTTA 430

  Fly   187 QVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKR 251
            |:.||::.|..:..........||..|::::....|:|..:|.|::.|..::.:..|.|.::..|
Zfish   431 QICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASALIGATVITVLAPLQYFVATR 495

  Fly   252 TSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILIS 316
            .|..:..|...|.||::..||::.||:::|:||||..|...||.||..|:..::          :
Zfish   496 LSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEETRRQELTSLR----------T 550

  Fly   317 FAMFLS-RIFTSSSL-IAFVLLGNI------------LNAEKAFFVTAYYNILRRSVTMFF--PQ 365
            ||::.| .||.:::: ||.||...:            |:...||...:.::||   ||..|  ..
Zfish   551 FALYTSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFGSLSLFHIL---VTPLFLLSS 612

  Fly   366 GISEFAELLVSVRRLEAFMHRPETK-----------------------------VRDKSKVK-NA 400
            .:....:.||||::|..|:...|.:                             |..|:|.| :.
Zfish   613 VLHSTVKALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNIKSVYALQLQAKLVNRKNKAKQDV 677

  Fly   401 NQKAESPNGDSPKGNGIPENL-IEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKS 464
            |:..|..:.:........:|: |:.......|....  |||.:|::::...:|..::|.||:|||
Zfish   678 NRNFEQQDQELRASAQHEDNICIKIVNGYFSWTQGC--PTLTNIDIKVPFGQLTMIVGQVGSGKS 740

  Fly   465 SLIQAILGELPGESGTLRIN-------------------------GSYSYAAQEPWLFTGTVRQN 504
            ||:.|.|||:...||::..|                         ||.:||:|.|||...||.:|
Zfish   741 SLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSGRQSFTRRGSVAYASQRPWLLNATVEEN 805

  Fly   505 ILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGER----GASLSGGQKARISLARAVYRRA 565
            |||....:..||:.|::.|.|..|.:.||.||:|::|||    |..|||||:.|||:|||:|::.
Zfish   806 ILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGERVRHLGIILSGGQRQRISVARALYQQT 870

  Fly   566 DIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSE--LVILVTHQLQFLEQADLIVIMDKGRISAMGT 628
            ::..||||.||:|.|:..||..:.:..:||.|  .|:||||:||:|..||.|:.|..|.:...||
Zfish   871 NVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVVLVTHKLQYLPHADWIIAMRDGTVQTQGT 935

  Fly   629 YSSMKRSGLD-FAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFT-- 690
            ...::.:..: |.|..|..|:.               |..|...|.|:..:.:...:|:...|
Zfish   936 LKDIQCAEPELFEQWRTLMNRQ---------------DKENSTELKRKSFRRAMMYSRDTVATDD 985

  Fly   691 ---SLSSMAESMAQEASLQMQ------ETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQI 746
               :::.:|.|..:::|....      |.|....|....:..|| ..:..|::..::...||...
Zfish   986 EDEAVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFATYL-KAAGLFLLPLLIVSQLAKHS 1049

  Fly   747 LCSAADYFLSYWVDKNVDGQTDIN----TDPQDMYY--------FAALNVAVVVFTIVRTMLFYK 799
            |..|.|::|::|....:..|::..    |..:|..:        |..|....:|..:|.::....
Zfish  1050 LMVAIDFWLAHWTSDVIAAQSESAERNCTFTKDCVFSHSWYLQVFCLLCALGIVLCLVTSLAVEW 1114

  Fly   800 MAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGI 864
            ..:|.:.:||.::.:.|..|.|..|.|.|.|.||||||.|...:|:.:|..|..:.:..|..:..
Zfish  1115 TGLRVAKELHCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTIDQHIPVTMECLSRSTLLCVSA 1179

  Fly   865 IVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALG 929
            :.||....|.:||..|.|.:..|:|::::...|||:::||.....|:.||.|.||.||.||||..
Zfish  1180 VGVISYVTPVFLIALLPLTVACYFIQKYFRVASRDLQQLEDSTEMPLLSHYSQTIEGLTTIRAFR 1244

  Fly   930 AQ----KELIAEFD--NLQDLHSSGYYTFL-ATNRAFGYYLDCFCTLYIVIIILNYFINP---PQ 984
            .:    |:|:...|  |:..|       || |.||.....::....|.::|..:....|.   ..
Zfish  1245 HEQRFKKKLLEHTDANNISSL-------FLTAANRWLEVRMEYIGALVVLIAAVASITNALYRQL 1302

  Fly   985 SPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPE 1049
            |.|.|||.:|.|:.::..:.|.:|..|::|..:..|:||......:||...:.....:....||:
Zfish  1303 SAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRVSGLIHTQPESYDNIMTPAQVPAGWPK 1367

  Fly  1050 KGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIIT 1113
            .|||..::|.:||  |...|.|||.::..|||.:||||.||||:||||...||||: ...||.|:
Zfish  1368 YGEIQIQNLSVRY--DSSLKPVLKHVSAHIRPGQKVGICGRTGSGKSSFSLALFRMVDTFEGQIS 1430

  Fly  1114 IDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPN 1178
            ||..|.:.:.|..||||.|||.|:|:||||::|:||||..:..|..||:|||..:|.|::..||.
Zfish  1431 IDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDPERKATDEMLWEALEIAQLMPVVKALPG 1495

  Fly  1179 GLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVL 1243
            ||.:.::|||.|||.|||||.|||||.:|::.:|:||||||::|..|::::|..:.:.|.|.||:
Zfish  1496 GLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATESILQKVVMTAFADRTVV 1560

  Fly  1244 TIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMV 1288
            |||||::||:.||.|:||..|.::|:..|..||...:| :|...|
Zfish  1561 TIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLLEQKDS-VFSAFV 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	427/1410 (30%)
abcc8b	XP_068071075.1	MRP_assoc_pro	239..1601	CDD:188098	425/1405 (30%)