DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp606

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_080388.2	Gene:	Zfp606 / 67370	MGIID:	1914620	Length:	794	Species:	Mus musculus

Alignment Length:	389	Identity:	111/389 - (28%)
Similarity:	155/389 - (39%)	Gaps:	77/389 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 EAENENPISS--DHDLISDTENT-NVEEIEDAGGDHVEDEATSDDQTSQEAVDEVAESPAAQDPL 312
            |.||....||  :|..|...|.| ...|.|...|        .|...:|......||.|...:..
Mouse   352 EYENIFYFSSFMEHQKIGSVEKTYKYNEWEKVFG--------YDSLLTQHTSTYTAEKPYEFNKC 408

  Fly   313 SVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKAAGEQKPKRSANPKTKEER------- 370
            ..:.   |:...|.|:        :|..| ..||...:|..   |..|:.:..||.||
Mouse   409 GTSF---IWSSYLIQH--------KKTHP-GEKPYECDKCG---KVFRNRSALTKHERTHTGVKP 458

  Fly   371 --------------NLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKT 421
                          :||...::......:||::||::|..:.:|..|...||..|.::||||.|:
Mouse   459 YECNKCGKAFSWNSHLIVHTRIHTGEKPYVCNECGKSFNWNSHLIGHQRTHTGEKPFECTECGKS 523

  Fly   422 FYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAP--------------RLI 472
            |..:.....|:|: |.||.||.|..|.:.|....|..|||.....|.|              .||
Mouse   524 FSWSSHLIAHMRM-HTGEKPFKCDECEKAFRDYSALSKHERTHSGAKPYKCTECGKSFSWSSHLI 587

  Fly   473 V-KRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRH 536
            . :|.:....|       |.|:.|.|.:..:.||..|...|:....|:|.:|.||.|....|.||
Mouse   588 AHQRTHTGEKP-------YNCQECGKAFRERSALTKHEIIHSGIKPYECNKCGKSCSQMAHLVRH 645

  Fly   537 EMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSH--ANSKMH 597
            :.||. ::|.:|:.|.|.|.|...|..|..|||||:||.|..|..:|    |..||  |:.:.|
Mouse   646 QRTHTGEKPYECNKCGKSFSQSCHLVAHRRIHTGEKPYKCNQCERSF----NCSSHLIAHRRTH 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	7/21 (33%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	399..422	CDD:290200	10/22 (45%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	7/24 (29%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
Zfp606	NP_080388.2	KRAB	63..123	CDD:214630
		KRAB	63..102	CDD:279668
		COG5048	386..792	CDD:227381	99/347 (29%)
		C2H2 Zn finger	406..425	CDD:275368	4/29 (14%)
		zf-H2C2_2	417..442	CDD:290200	8/36 (22%)
		C2H2 Zn finger	433..453	CDD:275368	7/22 (32%)
		zf-H2C2_2	445..469	CDD:290200	4/23 (17%)
		C2H2 Zn finger	461..481	CDD:275368	2/19 (11%)
		zf-H2C2_2	473..497	CDD:290200	6/23 (26%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		zf-H2C2_2	505..525	CDD:290200	9/19 (47%)
		C2H2 Zn finger	517..537	CDD:275368	8/20 (40%)
		zf-H2C2_2	529..552	CDD:290200	9/23 (39%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		zf-H2C2_2	557..581	CDD:290200	6/23 (26%)
		C2H2 Zn finger	573..593	CDD:275368	3/19 (16%)
		zf-H2C2_2	585..608	CDD:290200	8/29 (28%)
		C2H2 Zn finger	601..621	CDD:275368	6/19 (32%)
		zf-C2H2	627..649	CDD:278523	9/21 (43%)
		C2H2 Zn finger	629..649	CDD:275368	8/19 (42%)
		zf-H2C2_2	641..666	CDD:290200	10/24 (42%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		zf-H2C2_2	669..694	CDD:290200	12/28 (43%)
		C2H2 Zn finger	685..705	CDD:275368	7/23 (30%)
		zf-H2C2_2	697..721	CDD:290200	3/9 (33%)
		C2H2 Zn finger	713..733	CDD:275368
		zf-H2C2_2	725..748	CDD:290200
		zf-C2H2	739..761	CDD:278523
		C2H2 Zn finger	741..761	CDD:275368
		C2H2 Zn finger	769..789	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100