DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and ZNF691

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001229668.1	Gene:	ZNF691 / 51058	HGNCID:	28028	Length:	315	Species:	Homo sapiens

Alignment Length:	272	Identity:	76/272 - (27%)
Similarity:	121/272 - (44%)	Gaps:	32/272 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 PIASKPKAKEKAAGE------QKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHN 399
            |...|...:|..:.|      :||.:....:.:|..:.|...:..|....|:|.|||:.|..:.|
Human    65 PPGEKEHGQESLSDELQETHPKKPWQKVTVRARELGDPIAHPRHEADEKPFICAQCGKTFNNTSN 129

  Fly   400 LRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEV 464
            ||.|...||..|.|:|:||.|:|..:..|..|.|| |..|..:.|..|.|:|     |::.:...
Human   130 LRTHQRIHTGEKPYKCSECGKSFSRSSNRIRHERI-HLEEKHYKCPKCQESF-----RRRSDLTT 188

  Fly   465 HNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSD 529
            |..      ..:..:|         |:|.:|.|.::....|..|.::|.:...|.|..|.||:|:
Human   189 HQQ------DHLGKRP---------YRCDICGKSFSQSATLAVHHRTHLEPAPYICCECGKSFSN 238

  Fly   530 PNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNM----K 589
            .:....|..||. :||.:|..|.:.|...:....|:..|.||:||.|.||..:|....|:    |
Human   239 SSSFGVHHRTHTGERPYECTECGRTFSDISNFGAHQRTHRGEKPYRCTVCGKHFSRSSNLIRHQK 303

  Fly   590 SHANSKMHQDNA 601
            :|...:..:|::
Human   304 THLGEQAGKDSS 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	10/21 (48%)
		C2H2 Zn finger	387..407	CDD:275368	9/19 (47%)
		zf-H2C2_2	399..422	CDD:290200	12/22 (55%)
		C2H2 Zn finger	415..436	CDD:275368	9/20 (45%)
		C2H2 Zn finger	444..460	CDD:275368	5/15 (33%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	4/19 (21%)
		zf-met	574..597	CDD:289631	7/26 (27%)
		C2H2 Zn finger	575..591	CDD:275368	6/19 (32%)
ZNF691	NP_001229668.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		6/24 (25%)
		COG5048	<108..266	CDD:227381	54/178 (30%)
		C2H2 Zn finger	117..137	CDD:275368	9/19 (47%)
		C2H2 Zn finger	145..165	CDD:275368	9/20 (45%)
		C2H2 Zn finger	173..193	CDD:275368	6/30 (20%)
		C2H2 Zn finger	201..221	CDD:275368	5/19 (26%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..277	CDD:275368	4/19 (21%)
		zf-C2H2	283..305	CDD:306579	7/21 (33%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3304
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860