DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and CG4854

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	93/385 - (24%)
Similarity:	148/385 - (38%)	Gaps:	89/385 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 KCRTCYNDFTADFRAKDLFDPANSVLL-------FHIEVISGVWISHKPDEPRLMCPACKSALDQ 223
            |||.|            |..|.:..|:       ..|:..:||.:|..||.|..:|.:|...|..
  Fly    11 KCRIC------------LVQPKDESLMPTEPDFPDKIKRCTGVELSESPDWPNRICTSCALLLRA 63

  Fly   224 AIDFREMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTENTNVEEIEDAGGD-HVEDE 287
            |:..|.:|..||..|.:.|  ..|:.||.     :..:.:....||:.::.:.|..|.| .:|.|
  Fly    64 ALKLRSLCQQTEKDLKEQK--LQEINIEI-----VHDEQETKKKTESRDLSKNEATGSDSELEYE 121

  Fly   288 ATSDDQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGAPIASKPKAKEKA 352
            .......:.|:.::||.|  |.:.:|:                         .|..|.|   |::
  Fly   122 YLDSYDVTLESSEDVACS--ADELVSI-------------------------EPAISAP---EES 156

  Fly   353 AGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTE 417
            .....||    |.|.|:.:       ..:..:|.|:.|...:.....|..||..|:..|.::|..
  Fly   157 VYSLSPK----PVTFEDED-------SGQAASFTCNICNNVYSERVKLTNHMKVHSAKKPHECEI 210

  Fly   418 CPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMP 482
            |.|.|........|:. .|.|..|:.|.:|...||.|..|.||: .:|.          |.:|
  Fly   211 CHKRFRQTPQLARHMN-THTGNRPYKCDYCDSRFADPSTRIKHQ-RIHT----------NERP-- 261

  Fly   483 KPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHEK 542
                   |:|:.|.:.:.....|..|:|:||....:.||.|.||:|..:....||.:|::
  Fly   262 -------YKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEKSHKR 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	22/79 (28%)
		zf-C2H2	385..407	CDD:278523	6/21 (29%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		zf-H2C2_2	399..422	CDD:290200	8/22 (36%)
		C2H2 Zn finger	415..436	CDD:275368	5/20 (25%)
		C2H2 Zn finger	444..460	CDD:275368	6/15 (40%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
		C2H2 Zn finger	547..567	CDD:275368
		zf-met	574..597	CDD:289631
		C2H2 Zn finger	575..591	CDD:275368
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	14/56 (25%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	193..217	CDD:290200	9/23 (39%)
		COG5048	201..>258	CDD:227381	18/68 (26%)
		C2H2 Zn finger	208..228	CDD:275368	5/20 (25%)
		zf-H2C2_2	221..244	CDD:290200	6/23 (26%)
		C2H2 Zn finger	236..256	CDD:275368	8/20 (40%)
		zf-H2C2_2	251..273	CDD:290200	8/41 (20%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		zf-H2C2_2	277..301	CDD:290200	10/23 (43%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050