DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp229

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001158148.1	Gene:	Zfp229 / 381067	MGIID:	2679295	Length:	705	Species:	Mus musculus

Alignment Length:	574	Identity:	131/574 - (22%)
Similarity:	201/574 - (35%)	Gaps:	182/574 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 YNDFTADFRAK--DLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFREMCIS 233
            :.|...||..:  :..|.|...|..      ||.:.:..:...:....||:  |......::.|.
Mouse    15 FRDVAVDFSQEEWECLDSAQRALYI------GVMLENYSNLVSVGIIVCKA--DLVPHLEQIYIP 71

  Fly   234 TELKLSQ--AKP--------STDEVQIEAENENPISSDHDLISDTENTNVEEI-----EDAGG-- 281
            ..:|:.:  |||        |..|:....:::|.|....|:  ..:::...||     |.:||
Mouse    72 WNVKIKEMVAKPGRESYRMCSESEIVFYQDSKNIIYEHVDI--QWKSSECNEIGKMLHESSGGWI 134

  Fly   282 ----------------DHVEDEATSDDQTSQEAVDEVAESPA--------------AQDPLSVAL 316
                            |:.:|........|:.......|.|.              ......:.:
Mouse   135 LCKTNNTPEICNKYRFDNHKDAYIESTNLSRHKSMHTEEEPCKYKDYGKSLSLFSNVSQSHGIYI 199

  Fly   317 GAKIFKEL------------LDQYTGKEKARLRK---GAPIASKPKAKEKAAGEQKP-------- 358
            |.|.:||.            |..::||...:.||   |....|.....::....:||
Mouse   200 GEKEYKECDKTFGSFPKLVQLRIHSGKNPQKCRKCRTGFRTCSSLSTHQRTYTGEKPWICTECDK 264

  Fly   359 --KRSANPKT--------------------------KEERNL---------------IRRAQLRA 380
              :..::.||                          :|.:|:               .|.:.|||
Mouse   265 AFRWLSDLKTHYRIHPGEKPFKCKECDRSFTFYNSLREHQNIHKGKLYKCWKCDKFFTRCSSLRA 329

  Fly   381 --------KPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTF-YDAYMR---NMH-- 431
                    ||  |.|.:|.::|.|...||.|...||..|.|:|.||.|:| |.:.:|   |||
Mouse   330 HEKIHTGEKP--FKCKECIKSFYMLSQLRKHARTHTGEKPYKCKECDKSFTYSSSLREHQNMHAG 392

  Fly   432 -----------------IRIR---HRGETPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRI 476
                             :|..   |.||.||.|..|.::|......:|| :..|..
Mouse   393 KLYKCQECDKCFTWCSSLRAHEKIHTGEKPFKCKECGKSFCMLSQLRKH-ARTHTG--------- 447

  Fly   477 NPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE 541
                 .||     |:||.|:|.:.....|..|.|.|.....|||:.|.|.:...:.||.|..||.
Mouse   448 -----EKP-----YKCKECEKSFTQCSTLRIHQKIHAGEKPYKCKECGKCFYKLSYLKVHYRTHT 502

  Fly   542 -KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANS 594
             ::|.||..|.|||.|.:.|:.||.|||||:||.|..|:.:|.:....:.|.::
Mouse   503 GEKPYQCKECGKGFSQLSCLKSHERIHTGEKPYKCSECDKSFTHCSTCRRHQST 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871	13/70 (19%)
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	11/22 (50%)
		C2H2 Zn finger	415..436	CDD:275368	11/46 (24%)
		C2H2 Zn finger	444..460	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	9/19 (47%)
		zf-met	574..597	CDD:289631	4/21 (19%)
		C2H2 Zn finger	575..591	CDD:275368	3/15 (20%)
Zfp229	NP_001158148.1	KRAB	13..73	CDD:214630	12/65 (18%)
		C2H2 Zn finger	205..223	CDD:275368	3/17 (18%)
		COG5048	<227..412	CDD:227381	38/186 (20%)
		C2H2 Zn finger	231..251	CDD:275368	4/19 (21%)
		C2H2 Zn finger	259..279	CDD:275368	2/19 (11%)
		C2H2 Zn finger	287..307	CDD:275368	2/19 (11%)
		C2H2 Zn finger	314..334	CDD:275368	4/19 (21%)
		COG5048	338..704	CDD:227381	79/241 (33%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..417	CDD:275368	1/19 (5%)
		C2H2 Zn finger	425..445	CDD:275368	5/20 (25%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	4/20 (20%)
		C2H2 Zn finger	564..584	CDD:275368
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..640	CDD:275368
		C2H2 Zn finger	648..668	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100