DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp948

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001002008.1	Gene:	Zfp948 / 381066	MGIID:	3040683	Length:	667	Species:	Mus musculus

Alignment Length:	640	Identity:	150/640 - (23%)
Similarity:	244/640 - (38%)	Gaps:	168/640 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KNPCICIEH---FKDEDIEGSLK-FEMGLAKKRTLRPGAVPCVNKSQESGSDRARKERSQRRRNQ 115
            |:|....:|   |:|..::.|.| :|               |::.:|.:
Mouse     3 KSPVNMSKHLLTFRDVAVDFSQKEWE---------------CLDSAQRA---------------- 36

  Fly   116 ELVAELLAEEEAKLIHPEATSFEQDSVYLSETVTMELDPLSGEEKLEELQKCRTCYNDFTADFRA 180
             |..:::.|..:.|:..|..|. :|:|:  :.|..|.:.....|..|.|.:...|     |.:..
Mouse    37 -LYIDVMVENYSNLVFVEKYSV-RDTVH--QHVRTEKESRQCNELGEMLHEPTNC-----APYNT 92

  Fly   181 KDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFREMCISTELKLSQAKPST 245
            .|..:.:|:....:.:..|  ..|..||..:.:...     ::..::::...|:.:...|...|.
Mouse    93 SDTTETSNNYRCCNDQDAS--VDSSNPDRLKSVHTG-----EERCEYKDCEKSSSIAQDQRTNSA 150

  Fly   246 DEVQIEAENENPISSDHDLISD-------TENTNVEEIEDAGGDHVEDEATSDDQTSQEAV---D 300
            ::.|.:.::....||.|.|.|.       |.:.|.|:.::..|.|.    :|.....|:|:   :
Mouse   151 NKEQRQEKHGGHFSSTHSLKSSSIAQDQRTNSANKEQGQEKHGGHF----SSTHSLMQQAIFNRE 211

  Fly   301 EVAESPAAQDPLSVALGAKIFKELLDQYTG-------------------KEKARLRKGAPIASKP 346
            :..:....|...|.:....|.:.:   :||                   |...||..|    .||
Mouse   212 KRYQCGQCQRCFSTSANLTIHQRI---HTGEKPYKCNFCDKSFAQCTTLKTHQRLHTG----EKP 269

  Fly   347 -KAKEKAAGEQKPKRSA-----------NP-KTKE-ER-----NLIRRAQL--RAKP---PN--- 384
             |.||  .|:..|:.||           .| |.|| :|     :..||.|.  |||.   |:
Mouse   270 YKCKE--CGKSFPQLSALKSHQKMHTGEKPYKCKECDRFFAHCSSFRRHQKTHRAKKHTGPDCGK 332

  Fly   385 --------------------FVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRN 429
                                :.|.:|.::|......|||...|:...:|:|.||.|:|.:.....
Mouse   333 DLHQLSHFKSDHRLHTGENPYKCSECDRSFPHYELFRIHQKTHSSEIDYECEECGKSFTELLQLR 397

  Fly   430 MHIRIRHRGETPFACGFCSETFAYPGARQKHE----------------SEVHNAAPRLIVKRINP 478
            .|.:| |.|.|.:.|..|.::|......|||:                |.:||:   |:.:..:.
Mouse   398 RHYKI-HSGATLYKCRDCDKSFTQYSHLQKHQTIHTGERPYKCKDCEKSFLHNS---LLRRHQSV 458

  Fly   479 KPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHEK- 542
            ....||     |:||.|.|.:.....|..|.|.||....|||..|.||::....|:.|:..|.|
Mouse   459 HTGEKP-----YKCKECDKSFTRNSILRQHQKIHTKEKPYKCVECDKSFTQLTYLRTHQRVHTKE 518

  Fly   543 RPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMH 597
            :|..|.||.|.|.....||.|:.:|||||||.|..|..:||....:::|  .|:|
Mouse   519 KPYNCTVCDKSFTTGATLRIHQRVHTGERPYRCTECGKSFREGTTLRTH--KKIH 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	9/44 (20%)
		zf-AD	167..240	CDD:214871	9/72 (13%)
		zf-C2H2	385..407	CDD:278523	6/21 (29%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	415..436	CDD:275368	7/20 (35%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		zf-met	574..597	CDD:289631	6/22 (27%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
Zfp948	NP_001002008.1	KRAB	12..52	CDD:396083	10/71 (14%)
		COG5048	195..595	CDD:227381	107/401 (27%)
		C2H2 Zn finger	216..236	CDD:275368	3/22 (14%)
		C2H2 Zn finger	244..264	CDD:275368	2/19 (11%)
		C2H2 Zn finger	272..292	CDD:275368	6/21 (29%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	328..346	CDD:275368	1/17 (6%)
		C2H2 Zn finger	355..375	CDD:275368	6/19 (32%)
		C2H2 Zn finger	383..403	CDD:275368	7/20 (35%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		C2H2 Zn finger	439..459	CDD:275368	4/22 (18%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		C2H2 Zn finger	523..543	CDD:275368	8/19 (42%)
		C2H2 Zn finger	551..571	CDD:275368	6/21 (29%)
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	591..615	CDD:404364
		C2H2 Zn finger	607..627	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100