DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp39

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001100474.2	Gene:	Zfp39 / 303173	RGDID:	1306633	Length:	717	Species:	Rattus norvegicus

Alignment Length:	712	Identity:	156/712 - (21%)
Similarity:	254/712 - (35%)	Gaps:	212/712 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RNFSDCRSKRNAAQ----------QQRLGFFRFPKCPDTFKAWLAFCGYTEESLKLKNPCICIEH 63
            ||....|::.:.:|          |:|    .:.|.|.|:..|.  ......:.:.|.|...:..
  Rat     2 RNLQHNRAENSTSQRPSRRPETGKQKR----SYKKKPVTYSHWR--WSQRNGARRHKAPAKGLVS 60

  Fly    64 FKD-------------EDIEGSLKFEMGLAKKRTLRPGAVPCVNKSQ-----ESGS------DRA 104
            |:|             :|.:..|..::.|...|:|. ....||.|.:     |.|:      |..
  Rat    61 FEDVSVDFTWDEWQDLDDAQRKLYRDVMLETYRSLE-SLGHCVTKPEVIFKLEQGTGPWRAEDIP 124

  Fly   105 RKERSQRRRNQELVAELLAEEEAKLIH---PEATSFEQDSVYLSETVTMELDPLSGEEKLEELQK 166
            ::.|...|:.:||.......||..|.|   ..:.:..|:.|.|...:.:..:.:|.
  Rat   125 KQSRPDVRKVRELSETNQDNEERHLWHFVITNSNTSTQEKVKLGNILNVGSNRVSN--------- 180

  Fly   167 CRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKP----------DEP----------- 210
             ||..|..::..|                .|..|||.|..|          :||
  Rat   181 -RTIKNGNSSGMR----------------PVTLGVWQSASPSKEPSDLPTGEEPDGSLTSKPPMH 228

  Fly   211 ---------------RLMCPACKSALDQAIDFREMCISTEL--------------KLSQAKPSTD 246
                           ...|  |:         :|...||:.              |.|:::.:.|
  Rat   229 AEHHGLYNRAPGTGQHFQC--CR---------QEATCSTKALWTNKGFHVAHRSSKFSESEKAPD 282

  Fly   247 EVQIEAENENPISSD-------------------HDLI---------SDTENTNV-------EEI 276
            ||.:.|:..:.:..:                   |..|         .|.|.|.:       :.|
  Rat   283 EVALNAQEMSWVCKETFECSICKETFCTKFKLTKHKKIHKGQKYFTCRDCEKTFINTSYHKDQRI 347

  Fly   277 EDAGGDHVEDEATS-DDQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLRKGA 340
            ....|.|...:..: ..|.:|::|.:           ||..|:|:::....:.:..||..||
  Rat   348 HVGVGSHRYKQCENCFHQKNQQSVHQ-----------SVPKGSKLYEMYQSEQSFSEKPNLR--- 398

  Fly   341 PIASKPKAKEKAAGEQKPKR--SANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNLRIH 403
                   ..:|.....||.|  ........:.:|.|..::......:.|.:|.:||....:|.||
  Rat   399 -------CCQKTRAGYKPYRCNMCGKSFYRKSHLSRHQRIHTGERPYGCKECKKAFFHKSSLTIH 456

  Fly   404 MLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHESEVHNAA 468
            ...||..|.|:|.:|.||||.....|:|.| .|.||.|:.|..|.:||             ::.:
  Rat   457 QRTHTGEKPYECKKCRKTFYCKSDLNVHHR-THTGEKPYECDECRKTF-------------YSKS 507

  Fly   469 PRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSYSDPNKL 533
            ..:|.::|:....|       |:|:.|||.:..|..|..|.|:||....|:|..|.|::...:.|
  Rat   508 HLIIHRKIHTGDKP-------YECQECQKTFNRKSNLTVHQKTHTGEKPYECDVCGKTFHRQSHL 565

  Fly   534 KRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGERPYWCEVCNVNFRYKYNMKSHANS 594
            ..|:..|. ::|.:|..|.|.|||::.|..|:..|||:|||.||.|...|.:|.::..|..|
  Rat   566 SMHQGIHSGEKPYKCKECGKAFYQKSSLSRHQRNHTGDRPYACEECRKTFLHKSSLTVHQRS 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	21/109 (19%)
		zf-AD	167..240	CDD:214871	18/122 (15%)
		zf-C2H2	385..407	CDD:278523	7/21 (33%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	10/22 (45%)
		C2H2 Zn finger	415..436	CDD:275368	9/20 (45%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		zf-met	574..597	CDD:289631	7/21 (33%)
		C2H2 Zn finger	575..591	CDD:275368	5/15 (33%)
Zfp39	NP_001100474.2	KRAB	59..118	CDD:214630	12/59 (20%)
		KRAB	59..98	CDD:279668	7/39 (18%)
		COG5048	296..697	CDD:227381	96/374 (26%)
		C2H2 Zn finger	301..321	CDD:275368	1/19 (5%)
		C2H2 Zn finger	329..348	CDD:275368	3/18 (17%)
		zf-C2H2	410..432	CDD:278523	3/21 (14%)
		C2H2 Zn finger	412..432	CDD:275368	2/19 (11%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		zf-H2C2_2	452..475	CDD:290200	10/22 (45%)
		C2H2 Zn finger	468..488	CDD:275368	9/20 (45%)
		zf-H2C2_2	480..503	CDD:290200	9/23 (39%)
		C2H2 Zn finger	496..516	CDD:275368	5/32 (16%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		zf-H2C2_2	564..587	CDD:290200	7/22 (32%)
		C2H2 Zn finger	580..600	CDD:275368	8/19 (42%)
		C2H2 Zn finger	608..628	CDD:275368	7/20 (35%)
		C2H2 Zn finger	636..656	CDD:275368
		zf-H2C2_2	648..673	CDD:290200
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	692..712	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100