DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6689 and Zfp26

DIOPT Version :9

Sequence 1:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_011240753.1	Gene:	Zfp26 / 22688	MGIID:	99173	Length:	965	Species:	Mus musculus

Alignment Length:	609	Identity:	143/609 - (23%)
Similarity:	239/609 - (39%)	Gaps:	124/609 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CGYTEESLKLKNPCICIEH-------FKDEDIEGSLKFEMGLAKKRTLRPGAVPCVNKSQESGSD 102
            |...||:........|:::       |:||.::.|.:.....|..:..:||||     :.|..:.
Mouse    18 CSQGEETEGESMLADCLKNCNKDFVTFQDEAVDFSEEEWTTKAPTQNSKPGAV-----AVEEHTS 77

  Fly   103 RARKERSQRRRNQELVAE---LLAEEEAKLIHPEATSFEQDSVYLSETVTMELDP----LSGEEK 160
            .|..|..::.:.::|..|   |......:....:|.:||..:|..::.....|||    |..:..
Mouse    78 LAAVELEKQLQTKDLAPEQDFLTRHTFMETQQVDAVTFEDVAVDFTQEEWTSLDPVQRNLYRDVM 142

  Fly   161 LEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPD----------EPRLMCP 215
            ||..|...|.         ...:|.|:         :||  |:..|.:          |..:...
Mouse   143 LENYQNLATV---------GGQMFKPS---------LIS--WLEKKVELTVIEQGILQEWEMHLK 187

  Fly   216 ACKSALDQAIDFREMCISTEL--KLSQAKPSTDEVQIEAE-NENPISSDHDLISDTENTNVEEIE 277
            ..::||.|...:.:|....:|  :.|..:|. |.||:.|. :|:.....|...|:|.||....::
Mouse   188 TKRTALQQDRFWSDMSNGMQLGREHSGGEPG-DPVQVGAVFSEDSCPQTHSSTSNTGNTFACNLD 251

  Fly   278 DAGGDHVEDEATSDDQTSQ--EAVDEVAESP-------AAQDPLSVALGAKIFKELLDQYTGKEK 333
            ......:..|.::::...|  :.|..:..:|       ..:..:..:...:.|...|:..|.
Mouse   252 GKDFQPLLKETSTEENIVQLNQCVKPLIFTPDVSQKKCTPEKSVECSDCGETFVNQLELQTH--- 313

  Fly   334 ARLRKGAPIASKPKAKEKAAGEQKPKRSANPKT----------------KEER--------NLIR 374
                     :|..:.|.....|:..:.|.:|.:                |.|:        |:..
Mouse   314 ---------SSSHREKNIHKSEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHM 369

  Fly   375 RAQLRAKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGE 439
            ::....||  :.|.:||:||....:|.:|:.:|||.|:|:|.||.|||........|:| .|.||
Mouse   370 QSHTVEKP--YDCKECGKAFTERSSLIVHLRQHTREKSYECKECGKTFIQPSRLTEHMR-SHTGE 431

  Fly   440 TPFACGFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYA-SKY 503
            .|:.|..|...||.......|           :......||         ::|.:|.|.:. |.|
Mouse   432 KPYQCDQCGNAFASSSYLTTH-----------LRTHTGEKP---------FECNICGKAFTRSSY 476

  Fly   504 ALGWHIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIH 567
            .|| ||::||....|:|:.|.|::|..:.|..|...|. :||..|..|.|.|....:|.||...|
Mouse   477 LLG-HIRTHTGEKPYECKVCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH 540

  Fly   568 TGERPYWCEVCNVNFRYKYNMKSH 591
            |||:|:.|:||...||....:|:|
Mouse   541 TGEKPFRCKVCARTFRNSSCLKTH 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6689	NP_650051.1	THAP	2..96	CDD:283206	13/57 (23%)
		zf-AD	167..240	CDD:214871	13/84 (15%)
		zf-C2H2	385..407	CDD:278523	7/21 (33%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	11/22 (50%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	9/20 (45%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-met	574..597	CDD:289631	7/18 (39%)
		C2H2 Zn finger	575..591	CDD:275368	6/15 (40%)
Zfp26	XP_011240753.1	KRAB	113..171	CDD:214630	17/77 (22%)
		C2H2 Zn finger	297..317	CDD:275368	4/31 (13%)
		COG5048	325..760	CDD:227381	79/264 (30%)
		C2H2 Zn finger	352..372	CDD:275368	3/19 (16%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		C2H2 Zn finger	408..428	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	5/30 (17%)
		C2H2 Zn finger	464..484	CDD:275368	9/20 (45%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	7/17 (41%)
		C2H2 Zn finger	576..596	CDD:275368
		COG5048	600..956	CDD:227381
		C2H2 Zn finger	604..624	CDD:275368
		C2H2 Zn finger	632..652	CDD:275368
		C2H2 Zn finger	660..680	CDD:275368
		C2H2 Zn finger	688..708	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	800..820	CDD:275368
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
		C2H2 Zn finger	884..904	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..956	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100