Protein Alignment mAcon2 and LEU1

DIOPT Version :10

• Sequence 1: NP_650042.2
• Gene: mAcon2 / 41326
• FlyBaseID: FBgn0037862
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_011506.1
• Gene: LEU1 / 852875
• SGDID: S000002977
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 825
• Identity: 209/825 - (25%)
• Similarity: 310/825 - (37%)
• Gaps: 178/825 - (21%)

  Fly    59 GPLTLSEKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTV- 122
            ||.||.:||..:|:...|    |.|...|.:  ||..:.:.|:........::|.|...|..|:
Yeast     8 GPRTLYDKVFDAHVVHQD----ENGSFLLYI--DRHLVHEVTSPQAFEGLENAGRKVRRVDCTLA 66

  Fly   123 HCDHLIEAQ-----------ISGDKDLARAKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQI-I 175
            ..||.|..:           |.......:.|.|...|..|    ...| .|......||:|.| .
Yeast    67 TVDHNIPTESRKNFKSLDTFIKQTDSRLQVKTLENNVKQF----GVPY-FGMSDARQGIVHTIGP 126

  Fly   176 LENYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCH-------LT 233
            .|.:..||..::..||||...|..|.|..|:|.::...|:|.       .|:|...       :.
Yeast   127 EEGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLAT-------QTIIQAKSKNMRITVN 184

  Fly   234 GKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFN 298
            ||:|...:.||:||.:..::...||||.::|:.|..:|::|.....::.||..|.||...:...:
Yeast   185 GKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPD 249

  Fly   299 ERMVTYLRA---TGRGAIADEATKNKDLLVPDEGCKYDKVIEINLDTLE--PLVNG--------P 350
            |....|.:.   ..:||..::|......|..|||.|:|.  |||::.::  |.:..        |
Yeast   250 ETTFQYTKGRPLAPKGAEWEKAVAYWKTLKTDEGAKFDH--EINIEAVDVIPTITWGTSPQDALP 312

  Fly   351 FT---PD---LAHPISKLGQNS-------EKNGYPMEIKVS--LIGSCTNSSYEDMGRCASIAND 400
            .|   ||   :..||.|.|...       |.|.....|||.  .||||||...||:...|::..
Yeast   313 ITGSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSCTNGRIEDLRSAAAVVR- 376

  Fly   401 ALGHGLKSCVPF-NVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVKMGEKN 464
              |..|.|.:.. .|.|||..|:.....:|:..:.::.|.......|..|:|.  ..|:....:.
Yeast   377 --GQKLASNIKLAMVVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGM--NPDILDAYER 437

  Fly   465 TIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRL-----------DFNPMTDELTGTDGK 518
            ...|| ||||.||..|...||  :.||.||.|..|||..           |.:....|:|..|.|
Yeast   438 CASTS-NRNFEGRQGALSRTH--LMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSEDEK 499

  Fly   519 TFKLKEPHGEELPSKGFDPGEDTY--QAPPAKADDIKVNVDPKSDRLQL------LEPFEKWDGK 575
                      ||.|..:|..|...  .||...|:|...::..|||....      ::||
Yeast   500 ----------ELESAAYDHAEPVQPEDAPQDIANDELKDIPVKSDDTPAKPSSSGMKPF------ 548

  Fly   576 DYIDLMVLIKIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNAEN-----------NEMNK 629
                          .|.:.|||  |..|.....|.|....|:.......           .:.::
Yeast   549 --------------LTLEGISA--PLDKANVDTDAIIPKQFLKTIKRTGLKKGLFYEWRFRKDDQ 597

  Fly   630 VKNQKTGSFDAVPAVARDYKANKIKW-----CAVGEENYGEGSSREHAALEPRHLGGVAIIVKSF 689
            .|:|:|           |:..|...|     ..|..:|:|.|||||||....:..|..:||..|:
Yeast   598 GKDQET-----------DFVLNVEPWREAEILVVTGDNFGCGSSREHAPWALKDFGIKSIIAPSY 651

  Fly   690 ARIHETNLKKQGMLALTFANPGDYDKVQP----SSKISILNLKDLAPGKPVDAEIKNNGSSDKIQ 750
            ..|...|..|.|:|.:........||:.|    ..|:.:    ||...|.:|::  .|...|..:
Yeast   652 GDIFYNNSFKNGLLPIRLDQQIIIDKLIPIANKGGKLCV----DLPNQKILDSD--GNVLVDHFE 710

  Fly   751 LN--------HTLNELQI-----QWFQAGSALNLMKELAAKGGDK 782
            :.        :.|:::.|     ::.....||...|....:||.|
Yeast   711 IEPFRKHCLVNGLDDIGITLQKEEYISRYEALRREKYSFLEGGSK 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	205/813 (25%)
LEU1	NP_011506.1	PRK05478	9..480	CDD:235490	137/498 (28%)
		leuD	545..736	CDD:129275	48/229 (21%)