DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and LEU1

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_011506.1	Gene:	LEU1 / 852875	SGDID:	S000002977	Length:	779	Species:	Saccharomyces cerevisiae

Alignment Length:	825	Identity:	209/825 - (25%)
Similarity:	310/825 - (37%)	Gaps:	178/825 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GPLTLSEKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTV- 122
            ||.||.:||..:|:...|    |.|...|.:  ||..:.:.|:........::|.|...|..|:
Yeast     8 GPRTLYDKVFDAHVVHQD----ENGSFLLYI--DRHLVHEVTSPQAFEGLENAGRKVRRVDCTLA 66

  Fly   123 HCDHLIEAQ-----------ISGDKDLARAKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQI-I 175
            ..||.|..:           |.......:.|.|...|..|    ...| .|......||:|.| .
Yeast    67 TVDHNIPTESRKNFKSLDTFIKQTDSRLQVKTLENNVKQF----GVPY-FGMSDARQGIVHTIGP 126

  Fly   176 LENYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCH-------LT 233
            .|.:..||..::..||||...|..|.|..|:|.::...|:|.       .|:|...       :.
Yeast   127 EEGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLAT-------QTIIQAKSKNMRITVN 184

  Fly   234 GKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFN 298
            ||:|...:.||:||.:..::...||||.::|:.|..:|::|.....::.||..|.||...:...:
Yeast   185 GKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPD 249

  Fly   299 ERMVTYLRA---TGRGAIADEATKNKDLLVPDEGCKYDKVIEINLDTLE--PLVNG--------P 350
            |....|.:.   ..:||..::|......|..|||.|:|.  |||::.::  |.:..        |
Yeast   250 ETTFQYTKGRPLAPKGAEWEKAVAYWKTLKTDEGAKFDH--EINIEAVDVIPTITWGTSPQDALP 312

  Fly   351 FT---PD---LAHPISKLGQNS-------EKNGYPMEIKVS--LIGSCTNSSYEDMGRCASIAND 400
            .|   ||   :..||.|.|...       |.|.....|||.  .||||||...||:...|::..
Yeast   313 ITGSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSCTNGRIEDLRSAAAVVR- 376

  Fly   401 ALGHGLKSCVPF-NVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVKMGEKN 464
              |..|.|.:.. .|.|||..|:.....:|:..:.::.|.......|..|:|.  ..|:....:.
Yeast   377 --GQKLASNIKLAMVVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGM--NPDILDAYER 437

  Fly   465 TIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRL-----------DFNPMTDELTGTDGK 518
            ...|| ||||.||..|...||  :.||.||.|..|||..           |.:....|:|..|.|
Yeast   438 CASTS-NRNFEGRQGALSRTH--LMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSEDEK 499

  Fly   519 TFKLKEPHGEELPSKGFDPGEDTY--QAPPAKADDIKVNVDPKSDRLQL------LEPFEKWDGK 575
                      ||.|..:|..|...  .||...|:|...::..|||....      ::||
Yeast   500 ----------ELESAAYDHAEPVQPEDAPQDIANDELKDIPVKSDDTPAKPSSSGMKPF------ 548

  Fly   576 DYIDLMVLIKIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNAEN-----------NEMNK 629
                          .|.:.|||  |..|.....|.|....|:.......           .:.::
Yeast   549 --------------LTLEGISA--PLDKANVDTDAIIPKQFLKTIKRTGLKKGLFYEWRFRKDDQ 597

  Fly   630 VKNQKTGSFDAVPAVARDYKANKIKW-----CAVGEENYGEGSSREHAALEPRHLGGVAIIVKSF 689
            .|:|:|           |:..|...|     ..|..:|:|.|||||||....:..|..:||..|:
Yeast   598 GKDQET-----------DFVLNVEPWREAEILVVTGDNFGCGSSREHAPWALKDFGIKSIIAPSY 651

  Fly   690 ARIHETNLKKQGMLALTFANPGDYDKVQP----SSKISILNLKDLAPGKPVDAEIKNNGSSDKIQ 750
            ..|...|..|.|:|.:........||:.|    ..|:.:    ||...|.:|::  .|...|..:
Yeast   652 GDIFYNNSFKNGLLPIRLDQQIIIDKLIPIANKGGKLCV----DLPNQKILDSD--GNVLVDHFE 710

  Fly   751 LN--------HTLNELQI-----QWFQAGSALNLMKELAAKGGDK 782
            :.        :.|:::.|     ::.....||...|....:||.|
Yeast   711 IEPFRKHCLVNGLDDIGITLQKEEYISRYEALRREKYSFLEGGSK 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	205/813 (25%)
		AcnA_Mitochondrial	93..503	CDD:153134	126/458 (28%)
		Aconitase_swivel	585..733	CDD:294147	40/167 (24%)
LEU1	NP_011506.1	PRK05478	9..480	CDD:235490	137/498 (28%)
LEU1	NP_011506.1	leuD	545..736	CDD:129275	48/229 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.8533	Normalized mean entropy	S129
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.820