DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and ACO1

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_195308.1	Gene:	ACO1 / 829737	AraportID:	AT4G35830	Length:	898	Species:	Arabidopsis thaliana

Alignment Length:	919	Identity:	248/919 - (26%)
Similarity:	367/919 - (39%)	Gaps:	221/919 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAGSMVRNFHTARFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVLYSHLDQP 75
            |..|.:||        ||:..:.:.|.                           ||:|......|
plant    46 LLESAIRN--------CDEFQVKSKDV---------------------------EKILDWENTSP 75

  Fly    76 DSQEIERGKSYLRLRPDRVALQDATAQMTLLQF---------ISSGLKKV--AVPSTVHCDHLIE 129
            ...||.       .:|.||.|||.|....::..         :.....|:  .||..:..||.::
plant    76 KQVEIP-------FKPARVLLQDFTGVPAVVDLACMRDAMNNLGGDSNKINPLVPVDLVIDHSVQ 133

  Fly   130 AQISGDKDLARAK-----DLNKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILENYA-----FPG 183
            ..::..::..:|.     ..|||.:.||. .:.|.:|:....|||||:||:.||..|     ..|
plant   134 VDVARSENAVQANMELEFQRNKERFAFLKWGSNAFHNMLVVPPGSGIVHQVNLEYLARVVFNTNG 198

  Fly   184 LL----MIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKD 244
            ||    ::||||||....|||....||||.:|...|...|..:..|.|:|..||||:....:..|
plant   199 LLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLTGKLRDGMTATD 263

  Fly   245 VILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATG 309
            ::|.|.::|...|..|..||:||.|:..:|....|||.||..|.|||...||.:...:.|||.||
plant   264 LVLTVTQMLRKHGVVGKFVEFHGEGMRELSLADRATIANMSPEYGATMGFFPVDHVTLQYLRLTG 328

  Fly   310 RGAIADEATK--------NK---DLLVPDEGCKYDKVIEINLDTLEPLVNGPFTPDLAHPISKLG 363
            |   :|:...        ||   |...|:....|...:|:||:.:||.|:||..|....|:.::.
plant   329 R---SDDTVSMIEAYLRANKMFVDYSEPESKTVYSSCLELNLEDVEPCVSGPKRPHDRVPLKEMK 390

  Fly   364 QNSEK--------------------------NGYPMEIK-----VSLIGSCTNSSYED-MGRCAS 396
            .:...                          ||...:::     ::.|.||||:|... |...|.
plant   391 ADWHSCLDNRVGFKGFAVPKEAQSKAVEFNFNGTTAQLRHGDVVIAAITSCTNTSNPSVMLGAAL 455

  Fly   397 IANDA--LGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVK 459
            :|..|  ||..:|..:..::.|||..|...:|:.|:...|.:.|.:::...|..|||  :..|:.
plant   456 VAKKACDLGLEVKPWIKTSLAPGSGVVTKYLAKSGLQKYLNQLGFSIVGYGCTTCIG--NSGDIH 518

  Fly   460 MGEKNTI---------VTSYNRNFTGRNDANPATHC-FVTSPEMATALAIAGRLDFNPMTDEL-T 513
            ....:.|         |.|.||||.||  .:|.|.. ::.||.:..|.|:||.:|.:..|..: |
plant   519 EAVASAIVDNDLVASAVLSGNRNFEGR--VHPLTRANYLASPPLVVAYALAGTVDIDFETQPIGT 581

  Fly   514 GTDGKTFKLKE--PHGEE---------LPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLE 567
            |.|||....::  |..:|         ||    |..:.||:| ..|.:.:...:...|..|.
plant   582 GKDGKQIFFRDIWPSNKEVAEVVQSSVLP----DMFKATYEA-ITKGNSMWNQLSVASGTLY--- 638

  Fly   568 PFEKWDGKD-YI--------------------DLMVLIKIKGKCTTDHISAAG------PWLKY- 604
               :||.|. ||                    |...|:......||||||.||      |..||
plant   639 ---EWDPKSTYIHEPPYFKGMTMSPPGPHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYL 700

  Fly   605 ----------------RGHLDNISNNMFIGATNAENNEMNKV--------KNQKTGSFDAVPAVA 645
                            ||:.:.::...|........:...:|        ..:|...|||    |
plant   701 MERGVDRRDFNSYGSRRGNDEIMARGTFANIRIVNKHLKGEVGPKTVHIPTGEKLSVFDA----A 761

  Fly   646 RDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANP 710
            ..|:........:....||.||||:.||..|..||..|:|.|||.|||.:||...|::.|.|...
plant   762 MKYRNEGRDTIILAGAEYGSGSSRDWAAKGPMLLGVKAVISKSFERIHRSNLVGMGIIPLCFKAG 826

  Fly   711 GDYDKV----QPSSKISI-LNLKDLAPGKPVDAEIKNNGSSDKIQLNHTLNELQIQWFQAGSAL- 769
            .|.:.:    |....|.: .|:.::.||:.|.. :.|||.|....|... .|:::.:|..|..|
plant   827 EDAETLGLTGQELYTIELPNNVSEIKPGQDVTV-VTNNGKSFTCTLRFD-TEVELAYFDHGGILQ 889

  Fly   770 ----NLMKE 774
                ||:|:
plant   890 YVIRNLIKQ 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	239/883 (27%)
		AcnA_Mitochondrial	93..503	CDD:153134	145/490 (30%)
		Aconitase_swivel	585..733	CDD:294147	49/183 (27%)
ACO1	NP_195308.1	PLN00070	1..898	CDD:215047	247/917 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820