Protein Alignment mAcon2 and aco2

DIOPT Version :10

• Sequence 1: NP_650042.2
• Gene: mAcon2 / 41326
• FlyBaseID: FBgn0037862
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_001011445.1
• Gene: aco2 / 496933
• XenbaseID: XB-GENE-1000785
• Length: 781
• Species: Xenopus tropicalis
• Alignment Length: 777
• Identity: 538/777 - (69%)
• Similarity: 629/777 - (80%)
• Gaps: 12/777 - (1%)

  Fly    10 CLAGSMV--------RNFHTARFPRCD--KVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLS 64
            ||..|.:        |.:|.:.. .|.  |||||:|:....:.|::|.:|::.::.||..|||||
 Frog     5 CLLASRLQQALGHGARRYHVSSV-LCQRAKVAMSHFEANEYINYERLDKNINIVRKRLDRPLTLS 68

  Fly    65 EKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTVHCDHLIE 129
            ||::|.|:|.|.:||:.|||:||||||||||:|||||||.:||||||||.:||||||:|||||||
 Frog    69 EKIVYGHIDDPVTQEVVRGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPRVAVPSTIHCDHLIE 133

  Fly   130 AQISGDKDLARAKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTP 194
            ||:.|:|||.||||:|:|||:||::|.|||.:||||||||||||||||||||||:|:||||||||
 Frog   134 AQLGGEKDLKRAKDINQEVYNFLATAAAKYGVGFWKPGSGIIHQIILENYAFPGVLLIGTDSHTP 198

  Fly   195 NGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGT 259
            ||||||.:|:||||||||||||.||||||||.|||..|||::||||||||||||||.||||||||
 Frog   199 NGGGLGGICIGVGGADAVDVMAGIPWELKCPNVIGVKLTGQLSGWTSPKDVILKVAGILTVKGGT 263

  Fly   260 GAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGAIADEATKNKDLL 324
            |||||||||||:||||||||||.|||||||||||:||:|.||..||..|||.|||..|.:.|..|
 Frog   264 GAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLDKTGRSAIASLADEFKSHL 328

  Fly   325 VPDEGCKYDKVIEINLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYE 389
            ||||||:||::||||||.|:|.:|||||||||:|:|::|..:|:.|:|::|:|.|||||||||||
 Frog   329 VPDEGCEYDQLIEINLDELKPHINGPFTPDLANPVSEVGAVAEQKGWPLDIRVGLIGSCTNSSYE 393

  Fly   390 DMGRCASIANDALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWD 454
            ||||.|::|..||.||||....|.:||||||:||||.|||...||...||.||||||||||||||
 Frog   394 DMGRAAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAAVLRDVGGVVLANACGPCIGQWD 458

  Fly   455 RKDVKMGEKNTIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKT 519
            |||:|.||||||||||||||||||||||.||.||||||:.|||:|||.|.|:|..|.|||.|||.
 Frog   459 RKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALSIAGTLKFDPEKDFLTGADGKK 523

  Fly   520 FKLKEPHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLI 584
            |||:.|..:|||...||||:||||.||.:...:||:|.|.|.||||||||:||||||..::.:|:
 Frog   524 FKLQPPDADELPKSSFDPGQDTYQHPPKEGSSLKVDVSPTSQRLQLLEPFDKWDGKDLENMQILV 588

  Fly   585 KIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNAENNEMNKVKNQKTGSFDAVPAVARDYK 649
            |:|||||||||||||||||:||||||||||:.|||.|.|||:.|.|||.....:.|||..||.||
 Frog   589 KVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINLENNKANSVKNCVNQEYGAVPDTARYYK 653

  Fly   650 ANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYD 714
            |:.|||..:|:|||||||||||||||||||||.|||.|||||||||||||||:|.|||::|.|||
 Frog   654 AHGIKWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFSDPADYD 718

  Fly   715 KVQPSSKISILNLKDLAPGKPVDAEIKN-NGSSDKIQLNHTLNELQIQWFQAGSALNLMKEL 775
            |:.|..||:|..||.|||||||...|.: |||.:.|.||||.||.||:|||||||||.||||
 Frog   719 KIHPEDKITIAELKHLAPGKPVKCIITHQNGSQETILLNHTFNETQIEWFQAGSALNRMKEL 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	522/729 (72%)
aco2	NP_001011445.1	aconitase_mito	47..777	CDD:273561	522/729 (72%)