Protein Alignment mAcon2 and Irp-1A

DIOPT Version :10

• Sequence 1: NP_650042.2
• Gene: mAcon2 / 41326
• FlyBaseID: FBgn0037862
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_477371.1
• Gene: Irp-1A / 42689
• FlyBaseID: FBgn0024958
• Length: 902
• Species: Drosophila melanogaster
• Alignment Length: 859
• Identity: 242/859 - (28%)
• Similarity: 359/859 - (41%)
• Gaps: 173/859 - (20%)

  Fly    65 EKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQF---------ISSGLKKV--AV 118
            ||.:.|.|....|.:.|.....:..:|.||.|||.|....::.|         :....:|:  ..
  Fly    60 EKDVQSILGWTPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPIC 124

  Fly   119 PSTVHCDHLIEAQISGDKD-LARAKDL----NKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILE 177
            |:.:..||.::.......| |.:.:.|    |||.:.||. .|.|..|:....|||||:||:.||
  Fly   125 PADLVIDHSVQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLE 189

  Fly   178 NYA----------------FPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPT 226
            ..|                :|. .::||||||....|||.|..||||.:|..||......:..|.
  Fly   190 YLARVVFESDSSADGSKILYPD-SVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPE 253

  Fly   227 VIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGAT 291
            |||..|.||:....:..|::|.:.:.|...|..|..||::||||..:|....|||:||..|.|||
  Fly   254 VIGYRLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGAT 318

  Fly   292 TSIFPFNERMVTYLRATGRGAIADE-------ATKN-KDLLVPDEGCKYDKVIEINLDTLEPLVN 348
            ...||.:|..::|:|.|.|.....:       ||:. :|..:.|:..:|.:.:.::|.|:...|:
  Fly   319 VGYFPIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVS 383

  Fly   349 GPFTP------------------------DLAHPISKLGQNSE---------KNGYPMEIKVSLI 380
            ||..|                        ..|.|.|.|..:.|         |.|:. .:.::.|
  Fly   384 GPKRPHDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHG-SVVIAAI 447

  Fly   381 GSCTNSSYED-MGRCASIANDALGHGLKSCVPF---NVTPGSEQVRATIARDGIIDVLEKFGGTV 441
            .||||:|... |.....:|.:|:..|| |.:|:   :::|||..|...:...|:|..||:.|..:
  Fly   448 TSCTNTSNPSVMLGAGLLAKNAVQKGL-SILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDI 511

  Fly   442 LANACGPCIGQ---WDRKDVKMGEKNTI----VTSYNRNFTGRNDANPATHCFVTSPEMATALAI 499
            :...|..|||.   .|...|...|||.:    |.|.||||.||...|...: ::.||.:..|.||
  Fly   512 VGYGCMTCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRAN-YLASPLLVIAYAI 575

  Fly   500 AGRLDFNPMTDELTGTDGKTFKLKEPHGEELPSKGFDPGEDTYQ------APPAKADDIKVNVDP 558
            |||:|.:...:.| |.|.        :|:|:..:...|.....|      ..||...::...:..
  Fly   576 AGRVDIDFEIEPL-GVDS--------NGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQL 631

  Fly   559 KSDRLQLLEPFEK----W-DGKDYIDL--------MVLIKIKG----KC--------TTDHISAA 598
            .|...|.||..:.    | :...||.|        ..|.|:||    :|        ||||||.|
  Fly   632 GSRDWQTLEVSDSKLYPWSEISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPA 696

  Fly   599 GP---------WLKYRGHLDNISNN---------MFIGATNAENNEMNKVKNQKTGS-------- 637
            |.         :|..||......|:         :....|.|....:||:.: |||.
  Fly   697 GSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLAS-KTGPSTLHVPSG 760

  Fly   638 -----FDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNL 697
                 |||    |..|.:.......|..::||.||||:.||..|..||..|:|.:|:.|||.:||
  Fly   761 EEMDIFDA----AERYASEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNL 821

  Fly   698 KKQGMLALTFANPGDYDKVQPSSKISILNL----KDLAPGKPVDAEIKNNGSSDKIQLNHTLNEL 758
            ...|::.|.|. ||........|...:.|:    .:|.||:.:..:...|.....::.:   .|:
  Fly   822 VGMGIIPLQFL-PGQSADTLKLSGREVYNIVLPEGELKPGQRIQVDADGNVFETTLRFD---TEV 882

  Fly   759 QIQWFQAGSALNLM 772
            .|.:::.|..||.|
  Fly   883 DITYYKNGGILNYM 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	241/857 (28%)
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	242/859 (28%)