Protein Alignment mAcon2 and IREB2

DIOPT Version :10

• Sequence 1: NP_650042.2
• Gene: mAcon2 / 41326
• FlyBaseID: FBgn0037862
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_004127.2
• Gene: IREB2 / 3658
• HGNCID: 6115
• Length: 963
• Species: Homo sapiens
• Alignment Length: 930
• Identity: 242/930 - (26%)
• Similarity: 376/930 - (40%)
• Gaps: 221/930 - (23%)

  Fly    18 NFHTARFPRCDKVAMSNFDTGIP--LPYKKLRENLDCIKGRLGG---------PLTLS------- 64
            |.....||.  :|.:.:| ||||  :.:..:||   .:| .|||         |..|:
Human    75 NVEVPFFPA--RVLLQDF-TGIPAMVDFAAMRE---AVK-TLGGDPEKVHPACPTDLTVDHSLQI 132

  Fly    65 --EKVLYSHLDQPDSQEIER-GK-SYLRLRPDRVALQDATAQMTLLQFISSG------------- 112
              .|....:...|...:::: || |.|:::|.::..:   .|.|......||
Human   133 DFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCR---GQTTCRGSCDSGELGRNSGTFSSQI 194

  Fly   113 ----------LKKVAVPSTVHCDHLIEAQISGDKDLARAKDLNKEVYDFL--SSACAKYNLGFWK 165
                      |:.|..|.||..:..:|        ..|    |:|...|.  ||...| |:....
Human   195 ENTPILCPFHLQPVPEPETVLKNQEVE--------FGR----NRERLQFFKWSSRVFK-NVAVIP 246

  Fly   166 PGSGIIHQIILE----------NYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPW 220
            ||:|:.|||.||          :..||. .::|||||.....|||.|..||||.:...||..:|.
Human   247 PGTGMAHQINLEYLSRVVFEEKDLLFPD-SVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPV 310

  Fly   221 ELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMG 285
            .|..|.|:||.|||..:.:.:..||:|.:.:.|...|..|..||:.|.||..:|.....||.||.
Human   311 SLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMC 375

  Fly   286 AEIGATTSIFPFNERMVTYLRATGRGAIADEA----TKNKDLLVPDEGC----KYDKVIEINLDT 342
            .|.||..|.||.:...:.:|..||......|:    .|...|...|:..    :|.:||:|||::
Human   376 PEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNS 440

  Fly   343 LEPLVNGPFTPDLAHPISKLGQN-----SEKNGYP-------------------MEIKVS----- 378
            :.|.|:||..|.....::.:..:     :||.|:.                   .|.|:|
Human   441 IVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVV 505

  Fly   379 --LIGSCTNSSYEDMGRCAS-IANDALGHGL--KSCVPFNVTPGSEQVRATIARDGIIDVLEKFG 438
              .:.||||:....:...|. :|..|:..||  |..:..:::|||..|...::..|::..|.|.|
Human   506 IAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLG 570

  Fly   439 GTVLANACGPCIGQWD------RKDVKMGEKNTI-VTSYNRNFTGRNDANPATHC----FVTSPE 492
            ..::...|..|:|...      ...||.|:..|. :.|.|:||.||     ...|    ::.||.
Human   571 FEIVGYGCSICVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGR-----LCDCVRANYLASPP 630

  Fly   493 MATALAIAGRLDFNPMTDELTGTD--GKTFKLKE--PHGEE----------------LPSKGFDP 537
            :..|.||||.::.:..|:.| |||  ||...|.:  |..||                |..| .:.
Human   631 LVVAYAIAGTVNIDFQTEPL-GTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDK-IEM 693

  Fly   538 GE---DTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLM------VLIKIKGKCTTD 593
            |.   ::.:||    |.:....|.||..::....|:|.. |:.|.|.      ||:.:....|||
Human   694 GNKRWNSLEAP----DSVLFPWDLKSTYIRCPSFFDKLT-KEPIALQAIENAHVLLYLGDSVTTD 753

  Fly   594 HISAAG------PWLKY-------------------------RGHLDNIS-NNMFIGATNAENNE 626
            |||.||      ...||                         ||...||. .|.|||....:.
Human   754 HISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKT-- 816

  Fly   627 MNKVKNQKTGSFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFAR 691
            ::....|....|:|    |..|:...|....:..:.||.|:||:.||..|..||..|::.:|:.:
Human   817 IHFPSGQTLDVFEA----AELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEK 877

  Fly   692 IHETNLKKQGMLALTFANPGDYDKVQPSSK--ISILNLKDLAPGKPVDAEIKNNGSSDKI--QLN 752
            ||:.:|...|:..|.|....:.|.:..|.:  .|:...::|:||..::.:.    |:.|:  .:.
Human   878 IHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQT----STGKVFSVIA 938

  Fly   753 HTLNELQIQWFQAGSALNLM 772
            ...::::|..::.|..||.:
Human   939 SFEDDVEITLYKHGGLLNFV 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	233/901 (26%)
IREB2	NP_004127.2	PTZ00092	10..961	CDD:240263	242/930 (26%)