Protein Alignment Leash and ARRDC4

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_899232.2
• Gene: ARRDC4 / 91947
• HGNCID: 28087
• Length: 418
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 104/478 - (21%)
• Similarity: 172/478 - (35%)
• Gaps: 138/478 - (28%)

  Fly    11 DSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYTSKE 75
            |.....|.:|:.:.|.:.:..::...:||::::..|:....|.......::.:..:.::|   .|
Human    26 DERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVF---SE 87

  Fly    76 VYEHSETPLPDFEPRGLE----LSAGEHTFIFEVALGRQLPS-----SFKGSYGAIKYKMRVLIQ 131
            | |:....|...||...|    |..|:|.|.|..    ||||     ||.|.||:|:|.:|.:::
Human    88 V-EYLNVRLSLREPPAGEGIILLQPGKHEFPFRF----QLPSEPLVTSFTGKYGSIQYCVRAVLE 147

  Fly   132 RPWTFDERHTIPFTVVKNMPLQPMQRSIP--SSLEKQVTKTISLFGTRPITLLALLPEDFAVRGE 194
            ||...|:.......||.::.:.......|  .:.||.|  ....|.:.|::|.|.:.......||
Human   148 RPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMV--GCWFFTSGPVSLSAKIERKGYCNGE 210

  Fly   195 PLRICATVINNSTTAVEKLRFTVLQYVTYYS--------HVPLRVQKVECIAVATKETGSVQKKT 251
            .:.|.|.:.|.|:..:.. :..:.|..||.:        |:   |..|....:|:..|.:...||
Human   211 AIPIYAEIENCSSRLIVP-KAAIFQTQTYLASGKTKTIRHM---VANVRGNHIASGSTDTWNGKT 271

  Fly   252 ERSFAHELLLPDGAQPTDEQMSG--VITIVYELRVEAVLRGFFKNLILNLPFKVYSQDPSNRQSS 314
                   |.:|    |....:..  :|.:.|.|.|...:.| .|.|:|.||. |....|.|
Human   272 -------LKIP----PVTPSILDCCIIRVDYSLAVYIHIPG-AKKLMLELPL-VIGTIPYN---- 319

  Fly   315 LRPPPPPRPNDGPPGPELGSGNLFEPALPVYPSLDSSIGSPSHSSQFSECSSINSITSDSSAATL 379
                              |.|           |.:|||     :||||
Human   320 ------------------GFG-----------SRNSSI-----ASQFS----------------- 333

  Fly   380 SPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSSPLMVQSYPPPHLPAYPPPE 444
                      ||||:.:.:...|               |..|.:.:.::.:.....|:|.||.|.
Human   334 ----------MDMSWLTLTLPEQ---------------PEAPPNYADVVSEEEFSRHIPPYPQPP 373

  Fly   445 S-------PQYSLL---ALTPPP 457
            :       |.::.:   ...|||
Human   374 NCEGEVCCPVFACIQEFRFQPPP 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	38/149 (26%)
		Arrestin_C	191..308	CDD:214976	30/126 (24%)
ARRDC4	NP_899232.2	Arrestin_N	22..169	CDD:425619	38/150 (25%)
		Arrestin_C	191..318	CDD:214976	33/143 (23%)
		PPxY motif 1. /evidence=ECO:0000305	350..353		1/2 (50%)
		PPxY motif 2. /evidence=ECO:0000305	395..398		2/2 (100%)