Protein Alignment Leash and LDB19

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_014967.3
• Gene: LDB19 / 854500
• SGDID: S000005849
• Length: 818
• Species: Saccharomyces cerevisiae
• Alignment Length: 643
• Identity: 115/643 - (17%)
• Similarity: 207/643 - (32%)
• Gaps: 230/643 - (35%)

  Fly     8 ITLDSADRVYFAGDIIRGEIWMN--VNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLF 70
            :||....:::|....:.....|.  :|.:|||..:|         .|
Yeast   144 VTLSLVQKIHFHKPFVPNISSMQTCMNCKTKITNMK---------SW------------------ 181

  Fly    71 YTSKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGA-----IKYKMRVLI 130
                |:..:::           :||.|.|::.|...:...:|.|  .|.||     :||::..::
Yeast   182 ----EIQSNTQ-----------DLSVGSHSYPFSYLIPGSVPCS--SSLGATAETQVKYELIAVV 229

  Fly   131 QRPWTFDERHTIPFTVVKNMP-----------LQ-----PMQRSIPSSLEKQVTKTISLFGTRPI 179
                |:.:.|...|:...:.|           ||     .:.||||...:|   .::.:|....:
Yeast   230 ----TYIDPHRNSFSSGHSTPRKEGSSSKKRLLQLAMPIAVTRSIPRGPDK---NSLRVFPPTEL 287

  Fly   180 TLLALLPEDFAVRGE-PLRICATVINNSTT--AVEKLRFTVLQYVTYYSHV-PLRVQKVECIAVA 240
            |..|:||.....:.. ||.:....:::...  .:.||.:.:.:.....:|. |:...::..:...
Yeast   288 TAAAVLPNVVYPKSTFPLEMKLDGVSSGDRRWRMRKLSWRIEETTRVKAHACPVHKHELRQLEEQ 352

  Fly   241 TKETGSVQKKTERSFAH---ELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPFK 302
            .|...|.:.|..||...   ||    |.|               :||..       |.:.|:|.:
Yeast   353 VKIKESEKSKKPRSHIKRYGEL----GPQ---------------IRVAV-------NSLENMPSQ 391

  Fly   303 VYSQDPSNRQSSLRPPPPPRPNDGPPGPELGSGNL-FEPALPVYPSLDSSIGS----PS------ 356
            ....:|...|:         ||...|.   .:||: .:...||....:...||    ||
Yeast   392 RLPGEPGREQA---------PNSSGPA---STGNVGLDDENPVNEDEEDQPGSEFIHPSDDALRQ 444

  Fly   357 --------------------HSSQFSE-------------------------------CSSINSI 370
                                :||.|:|                               |..:||.
Yeast   445 ELLMQQQRARQQQLQQELKNNSSLFTEEVRIISKGEMKSGWKTDFDNNGKIELVTEIDCMGLNSG 509

  Fly   371 TSD--SSAATL-SPAVGAGTGGMDMS----------YTS---------GSQSSQY--GSPSARTS 411
            .|:  ..|:|| :|:.|.....::::          |.|         ..::.||  |.|
Yeast   510 VSNPVMHASTLQTPSTGNKKPSINVACDIQDPNLGLYVSHILAVEIVVAEETLQYANGQP----- 569

  Fly   412 LRSSNVPYMPYSSSPLMVQSYPPPHL----PAYPPPESPQYSLLA---LTPPPAGVVAAPPTGGA 469
            :|..|......:::..|....|...|    |.:....:|:...:.   :||..:...........
Yeast   570 IRKPNSKNKKETNNNTMNVHNPDQRLAELSPIFANRNTPKVRRMGPEDITPVNSNKSNHSTNKEK 634

  Fly   470 AAGGAPAYS--QLPSTSASASFLQ------PRQAPGA---HELPPSYEELFGLANAPP 516
            |:.||...:  .:|:.:|....:|      .|...|.   .|:||.|:::..|  :||
Yeast   635 ASNGASNSNIVSVPTGAARVLRMQFRLTVTERSGLGISWDEEVPPIYQDVELL--SPP 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	27/161 (17%)
		Arrestin_C	191..308	CDD:214976	20/123 (16%)
LDB19	NP_014967.3	LDB19	144..346	CDD:404030	45/252 (18%)