Protein Alignment Leash and ALY2

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_012451.1
• Gene: ALY2 / 853361
• SGDID: S000003620
• Length: 1046
• Species: Saccharomyces cerevisiae
• Alignment Length: 506
• Identity: 111/506 - (21%)
• Similarity: 177/506 - (34%)
• Gaps: 170/506 - (33%)

  Fly    87 FEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRPWTF----DERHTIPFTVV 147
            |:|       |::.:.||..:.:..|.|.|..:|.::|.:...|:||..|    ..|..:  .:|
Yeast   285 FQP-------GDYIYAFEELIPQAYPESIKADFGFVEYFLFASIERPGAFKSNISARQVV--NIV 340

  Fly   148 KNMPLQPMQRSIPSSL----EKQVTKTISLFGTRPITLLALLPEDFAVRGEPLRICATVINNSTT 208
            :......::.|.|..:    |.|:...| :..::.|.|.|.||..|  :..||         ...
Yeast   341 RTQAHNSVEESEPIIISRDWENQLYYDI-VIASKDIILDAFLPITF--KFAPL---------DKV 393

  Fly   209 AVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSFAHELLLPDGAQPTDEQMS 273
            .:.::|..|.:.:.||    .|.:||..:....|...:.||..:        ||:  .|.|..:|
Yeast   394 TLHRIRIYVTETMEYY----CREKKVHRMEPTKKFLLTEQKGPK--------LPN--LPNDANLS 444

  Fly   274 GVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDPS-----NRQSSLRPPPPPRPNDGPP-GPEL 332
                       :|...|   ||:         |||.     |::...:...|.|.|:... .|:.
Yeast   445 -----------KAKNMG---NLL---------QDPKNGDLVNKEYEYQIFIPSRFNNHQQLHPDT 486

  Fly   333 GSGNL-----FEPALPVYPSLDS-------SIGSPSHSSQFSECSSINSITSDSSAATLSPAVGA 385
            ...|:     .:..|.:...:|:       ||.||.|... ..||..|         ||.|:.
Yeast   487 SYENIKANHWIKICLRLSRVVDNKRKHYEISIDSPIHVLH-RLCSHAN---------TLLPSY-- 539

  Fly   386 GTGGMDMSY---TSGSQSSQYGSPSARTSL-RSSNVPYMPYS--SSPLMVQSYPP-----PHLP- 438
              .|...|:   |..|.||...|.....:| .:||: :.|..  |||::..:..|     ||||
Yeast   540 --DGHPASFPKETDSSISSILESSDDNINLYHNSNI-FFPKEVLSSPVLSPNVQPLDILIPHLPS 601

  Fly   439 ---------------AYP----------------PPESPQYSLLA--------LTPPPAGVVAAP 464
                           ::|                .|||.|..|.:        :|.|.:.:...|
Yeast   602 TSLTRNSRQFNRNSKSHPSDNTIFNSAKLKSNIYQPESLQRELASPQAIPLSPITSPMSNMEVPP 666

  Fly   465 P--------TGGAAAGGAPAYSQLPSTSASASFLQPRQAPGAHELPPSYEE 507
            |        ...||:|     :.....|:|.|.:.||.       ||||::
Yeast   667 PDFDFSSDFISDAASG-----TTTTEVSSSESSILPRD-------PPSYKD 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	16/68 (24%)
		Arrestin_C	191..308	CDD:214976	22/116 (19%)
ALY2	NP_012451.1	Arrestin_N	<254..341	CDD:451447	15/64 (23%)
		Arrestin_C	360..526	CDD:214976	46/214 (21%)
		PTZ00112	620..>924	CDD:240274	21/98 (21%)