Protein Alignment Leash and ART5

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_011582.1
• Gene: ART5 / 852960
• SGDID: S000003300
• Length: 586
• Species: Saccharomyces cerevisiae
• Alignment Length: 441
• Identity: 88/441 - (19%)
• Similarity: 157/441 - (35%)
• Gaps: 133/441 - (30%)

  Fly    44 VTGKGKCKWMEILRKNS----------NNNEYSRS---------LFYTSKEVYE-HSETPLPDFE 88
            |||..    .|.||:|:          |||.:|.|         ||...:..|| ...|.||...
Yeast   185 VTGTP----FEGLRENARSRSSSSNTLNNNSHSYSNRDGSGSSYLFLMKRGNYELPFNTMLPPEV 245

  Fly    89 PRGLE-LSAGEHTFIFEVAL-GRQL-------PSSFKGSYGA-------IKYKMRVLIQRPWTFD 137
            ...:| |.:|...:.||..: ||||       .:|..|..|:       ::.|.:::|::   |.
Yeast   246 CETIEGLQSGSILYSFEAIIDGRQLWDTDLSVHTSPHGPIGSTSTSGNGMRTKNKIIIKK---FK 307

  Fly   138 ERHTIPFTVVKNMPLQ-------------PMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDF 189
            ....:....:.|:.:|             ..:.||||       :.:.:..|.|:. :.:.|.:.
Yeast   308 YLRILRTLSMDNLAMQEEISVGNTWRDKLQYETSIPS-------RAVPIGSTTPVK-IKIFPFEK 364

  Fly   190 AVRGEPLRICATVINNSTTAVEKLRFTVLQY-------VTYYSHVPLRVQKVECIAVATKETGSV 247
            .:|                 ::::...::||       ...|.. .:.|.|:..:|    :.|.:
Yeast   365 NIR-----------------LDRIEMALIQYYAMKDSSAQIYDD-EIAVMKITHLA----DFGPL 407

  Fly   248 QKKTERSFAHELLLPDGAQPTDEQ---MSGVITIVYELRVEAVLR----GFFKNLIL-------- 297
            ..|.:...  ...:||..:...:.   ...:|.::::|:|..:|:    |.:|||.:
Yeast   408 TDKLDVDC--PFTIPDNLKQITQDCCLQDNLIRVMHKLQVRILLQRQVDGEYKNLEIKAQLPMLL 470

  Fly   298 ----NLPFK--VYSQDPSNRQSSLRPPP------PPRPNDG-PPGPELGSGNLFEPALPVYPSLD 349
                :||.|  :...|..:.:...||..      ...|..| .||.||.|......|||..|
Yeast   471 FISPHLPMKGRLVLFDKHDGKIHFRPGELVPLFLTTYPAQGLTPGVELNSTTTAHLALPQPP--- 532

  Fly   350 SSIGSPSHSSQFSE--CSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGS 398
                 |::....::  ..::..:.:||...|:.....|.......||.:||
Yeast   533 -----PNYHESTNDHLMPALQPLGADSVVLTVPSYEQAQAQASASSYVTGS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	35/143 (24%)
		Arrestin_C	191..308	CDD:214976	22/144 (15%)
ART5	NP_011582.1	Arrestin_C	332..475	CDD:460676	26/174 (15%)