Protein Alignment Leash and ECM21

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_009449.1
• Gene: ECM21 / 852173
• SGDID: S000000197
• Length: 1117
• Species: Saccharomyces cerevisiae
• Alignment Length: 603
• Identity: 116/603 - (19%)
• Similarity: 197/603 - (32%)
• Gaps: 211/603 - (34%)

  Fly    60 SNNNEYSRSLFY---TSKEVY--------------EHSETPLPDFEPRGLELSAGEHTFIFEVAL 107
            :|:|:....||.   |.:.:|              :.::|.|  ::|       |::.|:..|..
Yeast   399 NNSNDRQMRLFKNIPTEERLYLDKTKTKASLLNAIDVNKTHL--YQP-------GDYVFLVPVVF 454

  Fly   108 GRQLPSSFKGSYGAIKYKMRV---LIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTK 169
            ...:|.:.......:.|::|:   .|.|...:.:....|..:|.......:. |..|||  ::|:
Yeast   455 SNHIPETIYLPSARVSYRLRLATKAINRKGFYRQDSNSPQPIVSPDSSSSLS-STTSSL--KLTE 516

  Fly   170 TISLFGTRPI--TLLALLPEDFAV---------RGE-------PLRICAT-------------VI 203
            |.|....|.|  ||.:.:.....:         .||       |:::..|             .|
Yeast   517 TESAQAHRRISNTLFSKVKNHLHMSSHQLKNEESGEEDIFAEYPIKVIRTPPPVAVSTANKPIYI 581

  Fly   204 NNSTTAVEKLRFTV---LQYVTYYSHVPLRVQ-----KVECI----AVATKETGSVQKKTERSFA 256
            |...|  :.|.:.:   .:||:..|.||::::     |..|:    ...|:....|.|..|  :.
Yeast   582 NRVWT--DSLSYEISFAQKYVSLNSEVPIKIKLAPICKNVCVKRIHVSITERVTFVSKGYE--YE 642

  Fly   257 HELLLPDGAQPTD------------EQMSGVITI------VYELRVEAVLRGFFKNLILNLPFKV 303
            ::...|....|.:            |:...:..|      ...||.|.|...|..||:...||
Yeast   643 YDQTDPVAKDPYNPYYLDFASKRRKERSVSLFEIRTKEKGTRALREEIVENSFNDNLLSYSPF-- 705

  Fly   304 YSQDPSNRQSSLRPPPPPRPNDGPPGPELGSGNLFEPAL-------PVYPSLD------------ 349
              .|.|:             :.|.|...||   :.||.:       |.|..||
Yeast   706 --DDDSD-------------SKGNPKERLG---ITEPIIIETKLKFPKYEDLDKRTAKIIPPYGI 752

  Fly   350 ---SSIGSPSHSSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQS----------- 400
               :||.:|.|:            .::..:......:|.      :|...||:|
Yeast   753 DAYTSIPNPEHA------------VANGPSHRRPSVIGF------LSGHKGSKSHEENEKPVYDP 799

  Fly   401 --------SQYGSPSART--------------SLRSSNVPYMPYSSSPLMVQSYPPPHLPAYPPP 443
                    |..|.| .:|              ||..||| |..:....::..|.|.|..|:
Yeast   800 KFHQTIIKSNSGLP-VKTHTRLNTPKRGLYLDSLHFSNV-YCRHKLEIMLRISKPDPECPS---- 858

  Fly   444 ESPQYSLLALTP-------PPAGVVAAPPTGGAAAGGAPAYSQLPSTSASASFLQPRQAPGAHEL 501
            :...|.:|..||       ..:|.:..|....|...|..  :|:| .|.::.|......|
Yeast   859 KLRHYEVLIDTPIFLVSEQCNSGNMELPTYDMATMEGKG--NQVP-LSMNSDFFGNTCPP----- 915

  Fly   502 PPSYEELFGLANAPPGTP 519
            ||::||...:..:|..:|
Yeast   916 PPTFEEAISVPASPIVSP 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	19/111 (17%)
		Arrestin_C	191..308	CDD:214976	32/175 (18%)
ECM21	NP_009449.1	Arrestin_C	585..>648	CDD:214976	13/66 (20%)
		Arrestin_C	<781..878	CDD:214976	22/102 (22%)