Protein Alignment Leash and ARRDC5

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001354118.1
• Gene: ARRDC5 / 645432
• HGNCID: 31407
• Length: 350
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 68/336 - (20%)
• Similarity: 121/336 - (36%)
• Gaps: 67/336 - (19%)

  Fly    14 DRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYTSKEVYE 78
            ||:|.||..|:|::.:.:|.......:||::.|:|..:|.|   :...:.:|||::...:|..|.
Human    14 DRIYLAGSSIKGQVILTLNSTLVDPIVKVELVGRGYVEWSE---EAGASCDYSRNVICNNKADYV 75

  Fly    79 HSETPLP--------------------DFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIK 123
            |.....|                    ..:|.........|..:.. ....:|||:|...:|.:.
Human    76 HKTKTFPVEEMASRSVTQAGVQWHDLGSLQPPSRTFKLSSHLSLLS-TWNYRLPSTFTSKFGHVF 139

  Fly   124 Y----------------KMRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTIS 172
            |                :|.:|:|...||.:.             .|.|..:....|::|:....
Human   140 YFVQASCMGREHILAKKRMYLLVQGTSTFHKE-------------TPFQNPLFVEAEEKVSYNCC 191

  Fly   173 LFGTRPITLLALLPEDFAVRGEPLRICATVINNSTT-AVEKLRFTVLQYVTYYSHVP-----LRV 231
            ..||  :.|...:..:....||.: :..|.|||.|: .::.:.|.:..::.|....|     .|:
Human   192 RQGT--VCLQIQMERNTFTPGEKV-VFTTEINNQTSKCIKTVVFALYAHIQYEGFTPSAERRSRL 253

  Fly   232 QKVECI--AVATKETGSVQKKTERSFAHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGFFKN 294
            ...|.:  ...|..|.....|...:|...|||...:...|.:   ::...|||.....|.....:
Human   254 DSSELLRQEANTPVTRFNTTKVVSTFNLPLLLSVSSSTQDGE---IMHTRYELVTTVHLPWSLTS 315

  Fly   295 LILNLPFKVYS 305
            |...:|..:.|
Human   316 LKAKVPIIITS 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	34/173 (20%)
		Arrestin_C	191..308	CDD:214976	27/123 (22%)
ARRDC5	NP_001354118.1	Arrestin_N	13..146	CDD:451447	29/135 (21%)
		Arrestin_C	192..326	CDD:460676	29/139 (21%)