Protein Alignment Leash and ARRDC3

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_065852.1
• Gene: ARRDC3 / 57561
• HGNCID: 29263
• Length: 414
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 94/403 - (23%)
• Similarity: 162/403 - (40%)
• Gaps: 69/403 - (17%)

  Fly    11 DSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYTSK- 74
            ||...||.:||.:.|.:.:.|....:::::|:...|..|.:|.| .|...:|..|:::  ||.:
Human    18 DSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTE-SRNAGSNTAYTQN--YTEEV 79

  Fly    75 EVYEHSETPL-----PDFEPRGLE-LSAGEHTFIFEVALGR-QLPSSFKGSYGAIKYKMRVLIQR 132
            |.:.|.:..:     .|....|.. :.:|.|.:.|...|.: .|.:||:|.:|:::|.::..:.|
Human    80 EYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHR 144

  Fly   133 PWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFAVRGEPLR 197
            ||....:....|||.:::.:.......|.:..|:.|.......:.||:|.|.:.......||.::
Human   145 PWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQ 209

  Fly   198 ICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSFAHELLLP 262
            |.|.:.|.|:..|.. :..:.|...:|:...::..| :.:|....|:.| ..|||......|.:|
Human   210 IFAEIENCSSRMVVP-KAAIYQTQAFYAKGKMKEVK-QLVANLRGESLS-SGKTETWNGKLLKIP 271

  Fly   263 DGAQPTDEQM--SGVITIVYELRVEAVLRGFFKNLILNLPFKV--------------YSQDPSNR 311
                |....:  ..:|.:.|.|.|...:.|.. :|.||||..:              .|...|..
Human   272 ----PVSPSILDCSIIRVEYSLMVYVDIPGAM-DLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMN 331

  Fly   312 QSSLRPPPPPRPNDGPPG------PELGSGNL--------FEPAL----------------PVYP 346
            .:.|....|.|| :.||.      .|....||        ||.||                |:|.
Human   332 MNWLSLSLPERP-EAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYS 395

  Fly   347 SLDSSIGSPSHSS 359
            .:|.   :|..|:
Human   396 EIDP---NPDQSA 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	38/148 (26%)
		Arrestin_C	191..308	CDD:214976	30/132 (23%)
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:425619	36/145 (25%)
		Arrestin_C	187..314	CDD:214976	33/134 (25%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..414		4/16 (25%)