Protein Alignment Leash and Txnip

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001009935.1
• Gene: Txnip / 56338
• MGIID: 1889549
• Length: 397
• Species: Mus musculus
• Alignment Length: 383
• Identity: 82/383 - (21%)
• Similarity: 154/383 - (40%)
• Gaps: 66/383 - (17%)

  Fly     8 ITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYT 72
            :..:..::||.:|:.:.|.:.:.|.:.|:::|:::...|..|..||:..::.....:|.|
Mouse    12 VVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLR----- 71

  Fly    73 SKEVYEHSETPLPDFEPRGLELSAGEHTFI-------FEVALGRQLP-----SSFKGSYGAIKYK 125
                ||  :|.|.:.:|     :|||:..:       :|...|.:||     :||||.||.:.|.
Mouse    72 ----YE--DTLLLEEQP-----TAGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYW 125

  Fly   126 MRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFA 190
            ::..:.||....:.....|.|:..:.:.......|.|.:|:...:........:::.|.:.....
Mouse   126 VKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGF 190

  Fly   191 VRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRV--QKVECIAVATKETGSVQKKTER 253
            ..|:.:.|.|...|..:..|......|.:: ||.::...:|  ||:..:......:|:......:
Mouse   191 CEGDDISIHADFENTCSRIVVPKAAIVARH-TYLANGQTKVFTQKLSSVRGNHIISGTCASWRGK 254

  Fly   254 SFAHELLLPD--GAQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDP-SNRQSS- 314
            |...:.:.|.  |.        .::.:.|.|.:...:.| .|.:||:||..:.|:.. |:|.||
Mouse   255 SLRVQKIRPSILGC--------NILKVEYSLLIYVSVPG-SKKVILDLPLVIGSRSGLSSRTSSM 310

  Fly   315 ------------LRPPPPPRPNDGPPG-----PELGSGNLFEPALPVYPSLDSSIGSP 355
                        |..|..|   :.||.     ||  ...|..|..|:...:|.|..||
Mouse   311 ASRTSSEMSWIDLNIPDTP---EAPPCYMDIIPE--DHRLESPTTPLLDDVDDSQDSP 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	36/155 (23%)
		Arrestin_C	191..308	CDD:214976	24/120 (20%)
Txnip	NP_001009935.1	Arrestin_N	10..153	CDD:451447	36/156 (23%)
		Arrestin_C	175..299	CDD:460676	24/133 (18%)