Protein Alignment Leash and Arrdc1

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_038961503.1
• Gene: Arrdc1 / 366001
• RGDID: 1309961
• Length: 460
• Species: Rattus norvegicus
• Alignment Length: 559
• Identity: 126/559 - (22%)
• Similarity: 200/559 - (35%)
• Gaps: 161/559 - (28%)

  Fly     8 ITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYT 72
            |.|.....||..|:.:.|.:.:.:......|||:  ||..|.|.    :...:|:..      :.
  Rat     9 IRLSQGRVVYSPGEPLAGAVHLRLGAPLPFRAIR--VTCMGSCG----VSNKANDGA------WV 61

  Fly    73 SKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRP-WTF 136
            .:|.|.:|...|.|   :| .|..|||.|.|:..|....|:||:|.:|.|.:::|..|..| ::.
  Rat    62 VEESYFNSSLSLAD---KG-SLPPGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSK 122

  Fly   137 DERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFG-----TRPITLLALLPEDFAVRGEPL 196
            |.:.::.|.::..:.|    .|||...:..|..|...|.     |..:.|.|.......|.|:.|
  Rat   123 DHKCSLVFYILSPLNL----NSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVL 183

  Fly   197 RICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQK--VECIAVATKETGSVQKKTERSFAHEL 259
            |:.|.:.|.|......:..::||.|:|      :.::  .:...:|..|...|:......:..::
  Rat   184 RLQADIENQSGKDTSPVVASLLQKVSY------KAKRWIYDVRTIAEVEGTGVKAWRHAQWQEQI 242

  Fly   260 L---LPDGAQPTDEQMSGVITIVYELRVEAV-------LRG---------FFK------NLILNL 299
            |   ||..|.|.    ..:|.|.|.|:|...       |.|         ||:      ...:.|
  Rat   243 LVPALPQSALPG----CSLIHIDYYLQVWCCPGLGGLRLGGLGLTLQYLRFFQVSMKAPEATVTL 303

  Fly   300 PFKVYSQDPSNRQSSLRPPPPPRPNDGPPGPELGSGNLFEPALPVYPSLDS-------------- 350
            |  ::..:.:..|:.|.|.|.|..:.|          |..|.:|..|..:.
  Rat   304 P--LFVGNIAVNQTPLSPCPGPGSSPG----------LLSPVVPSAPPQEEAEAVASGPHFSDPV 356

  Fly   351 SIGSPSHSSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSS 415
            |:.:.|||.|....:::.|:    |..|:.|.|                  |.||| ||.||
  Rat   357 SLSTKSHSQQQPLSTTLGSV----SVTTIEPCV------------------QVGSP-ARHSL--- 395

  Fly   416 NVPYMPYSSSPLMVQSYPPPHLPAYPPPESPQYSLLALTPPPAGVVAAPPTGGAAAGGAPAYSQL 480
                                    :||        |.::     :.|..|.....:||
  Rat   396 ------------------------HPP--------LCIS-----IGATVPYFAEGSGG------- 416

  Fly   481 PSTSASASFLQPRQAPGA--HELPPSYEELFGLANAPPG 517
            |..:.||..|.|..:...  :|.|||||:..|......|
  Rat   417 PVPTTSALILPPEYSSWGYPYEAPPSYEQSCGAGGTDVG 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	38/144 (26%)
		Arrestin_C	191..308	CDD:214976	30/143 (21%)
Arrdc1	XP_038961503.1	Arrestin_N	7..139	CDD:451447	39/149 (26%)
		Arrestin_C	162..310	CDD:460676	33/159 (21%)
		PHA03247	<311..449	CDD:223021	46/217 (21%)