Protein Alignment Leash and ARRDC2

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_056498.1
• Gene: ARRDC2 / 27106
• HGNCID: 25225
• Length: 407
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 99/479 - (20%)
• Similarity: 173/479 - (36%)
• Gaps: 137/479 - (28%)

  Fly     8 ITLDSA----DRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRS 68
            :.||.|    :.|:..|..:.|.:.:.::...::.|::::..|:....|.| .|...::..|::|
Human    11 VQLDGATAGVEPVFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTE-SRSAGSSTAYTQS 74

  Fly    69 LFYTSK-EVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQR 132
              |:.: ||..|..|.|.........|..|.|.|:|...|...|.:||:|.:|:::|.::..:.|
Human    75 --YSERVEVVSHRATLLAPDTGETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHR 137

  Fly   133 PWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRP------------ITLLALL 185
            ||....|....|||:     :|:..:.|:.|..|.       |.|.            ::|.|.:
Human   138 PWVPARRARKVFTVI-----EPVDINTPALLAPQA-------GAREKVARSWYCNRGLVSLSAKI 190

  Fly   186 PEDFAVRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKK 250
            .......||.:.:.|.:.|.||..|.. |..|:|..|:.:....:.::....::|.:..|..|:.
Human   191 DRKGYTPGEVIPVFAEIDNGSTRPVLP-RAAVVQTQTFMARGARKQKRAVVASLAGEPVGPGQRA 254

  Fly   251 TERSFAHELLLPDGAQPTDEQM--SGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDPSNRQS 313
            ..:..|  |.:|    |....:  ..|:.:.|.|:|...:.|..| |:|.||..:
Human   255 LWQGRA--LRIP----PVGPSILHCRVLHVDYALKVCVDIPGTSK-LLLELPLVI---------- 302

  Fly   314 SLRPPPPPRPNDGPPGPELGSGNLFEPALPVYP--SLDSSIGS----------------PSHSSQ 360
                                      ..:|::|  |..||:||                |....:
Human   303 --------------------------GTIPLHPFGSRSSSVGSHASFLLDWRLGALPERPEAPPE 341

  Fly   361 FSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSS 425
            :||      :.:|:..|.|..:........|||...                     |:..|
Human   342 YSE------VVADTEEAALGQSPFPLPQDPDMSLEG---------------------PFFAY--- 376

  Fly   426 PLMVQSYPPPHLPAYPPPESPQYS 449
               :|.:      .|.||  |.||
Human   377 ---IQEF------RYRPP--PLYS 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	38/148 (26%)
		Arrestin_C	191..308	CDD:214976	28/118 (24%)
ARRDC2	NP_056498.1	Arrestin_N	9..158	CDD:425619	39/154 (25%)
		Arrestin_C	181..307	CDD:214976	30/169 (18%)