Protein Alignment Leash and arrd-22

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_503955.1
• Gene: arrd-22 / 188642
• WormBaseID: WBGene00020612
• Length: 456
• Species: Caenorhabditis elegans
• Alignment Length: 497
• Identity: 121/497 - (24%)
• Similarity: 198/497 - (39%)
• Gaps: 97/497 - (19%)

  Fly     2 ESERLRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNN--- 63
            ::|.|::..|..|.|:..|..|.|.:.:...|:...||:.:::.|.....|     ||..|:
 Worm     3 KTELLQVIFDQPDEVFLPGQPISGRVVLTTKKKLSARAVNIKIVGLAHTSW-----KNYENSCKL 62

  Fly    64 EYSRSLFYTSKEVYEHSETPLPDFE---------PRGLELSAGEHTFIFEVALGRQLPSSFKGSY 119
            .:.|.:.|....||..:.....|:.         |:  ||:|||:.:.|...|...:|.||:|.|
 Worm    63 SFHRIVSYRPHGVYYSANVKYLDYTQLLWTCGEGPK--ELNAGEYAWPFSYTLPLNIPPSFEGKY 125

  Fly   120 GAIKYKMRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTIS--LFGTRPITLL 182
            |.::|.::|.:.|||..|:...:..||...:.|..:..|: :.:..|.::.:.  .|....:.:.
 Worm   126 GYLRYTVKVEVDRPWRVDKAKKMCITVSPLLDLNVIPHSL-TPINTQASENLGCCCFKNGFLEMN 189

  Fly   183 ALLPEDFAVRGEPLRICATVINNSTTAVEKLRFTVLQY---------VTY-YSHVPLRVQKVECI 237
            ..:|:...|.||.:.:...:||:|::..:|:...:||.         .|| |.......:|.:.|
 Worm   190 VNIPKTGFVPGETVPLNIHLINHSSSTAKKIEAKILQQCKFTGYKDGATYNYGGDENMSEKAQRI 254

  Fly   238 AVATK------ETGSVQKKTERSFAHELLLPDGAQPTDEQMSGVITIVY--ELRVEAVLRGFFK- 293
            ...||      :...|..|.|..|..||.:| ...||..|.|.|:|:.|  :|:|:.......:
 Worm   255 MFDTKTVVRESQKLVVAAKNEHKFVLELRIP-SVTPTINQFSPVVTVEYLIQLKVDTSAMSHSEV 318

  Fly   294 ----NLILN-------LPFKVYSQDPSNRQSSLRPPPPPRPNDG-PPGPELGSGNLFEPALPVYP 346
                :::|.       ||...|.|||     |:.|..|....:| .|.|..||       ||:..
 Worm   319 RCETSILLGSVPIRQCLPPSYYQQDP-----SVLPSKPTPIGEGVAPPPGYGS-------LPMTD 371

  Fly   347 SLDSSIGSPSHSSQFSECSSIN----SITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPS 407
            ..:....:|.....:...:.:|    |:..|.:|...|        ....||    |.|.||...
 Worm   372 DSEKGTDAPYPLGLYPNVNDVNLPYPSVVQDGNAVIPS--------APPPSY----QESMYGKGG 424

  Fly   408 ARTSLRSSNVPYMPYSSSPLMVQSYP-----PPHLPAYPPPE 444
            .....: .|.||:|         .||     |.:.|..||||
 Worm   425 TVLDAK-ENEPYVP---------KYPVFNNLPVYNPTAPPPE 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	42/157 (27%)
		Arrestin_C	191..308	CDD:214976	37/146 (25%)
arrd-22	NP_503955.1	Arrestin_N	7..159	CDD:425619	42/158 (27%)
		Arrestin_C	182..330	CDD:214976	34/148 (23%)