Protein Alignment Leash and arrd-25

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_510338.1
• Gene: arrd-25 / 181514
• WormBaseID: WBGene00007296
• Length: 584
• Species: Caenorhabditis elegans
• Alignment Length: 427
• Identity: 100/427 - (23%)
• Similarity: 178/427 - (41%)
• Gaps: 91/427 - (21%)

  Fly     5 RLRITLDSADRVYF-AGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWM-EILRKNSNNNEYSR 67
            |..|.||:.|...| .|::|.|::.:.:.|...|.|:|:|:  ||:..|: :.|:|:.....|
 Worm    10 RFDIHLDAGDEPTFKGGELITGKLLIELRKPIIINAVKLQM--KGRAAWLNDPLKKDDIEKVY-- 70

  Fly    68 SLFYTSKEVYEHSETPLPDFEPRGLELSAGEHTFI--FEVALGRQLPSSFKGSYGAIKYKMRVLI 130
                 ..:.:...|.|....||...:. .|:.|:.  ||..|.:..||:::|.:..|:|.:|..:
 Worm    71 -----FDQDFTLLERPPGKPEPGHFQW-IGDFTYSLPFECPLPKGCPSTYEGPHAFIRYFIRASL 129

  Fly   131 QRPWTFDERHTI----PFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFG-----TRPITLLAL-- 184
            .:...|::.|..    .||:|     .|.:..|.:. |...|...::.|     ::....|||
 Worm   130 VQEDEFEKIHEYYVKKAFTLV-----SPSEGHIVTG-EAAQTDDSAILGKCCCKSKLAAELALSK 188

  Fly   185 ---LPEDFAVRGEPLRICA----TVINN-STTAVEKLRFTVLQYVTYYSHVPLR---VQKVECIA 238
               ||.: |:.|. |:|.:    .::|: ....|:::|......::..|  |.|   |:|:|
 Worm   189 TGYLPGE-AIYGN-LKIGSKHPKDILNHMEARLVDRVRRVGAPEISAAS--PWRTLLVRKLE--- 246

  Fly   239 VATKETGSVQK-KTERSFAHELLLPDGAQPTD---EQMSGVITIV--YELRVE----AVLR---- 289
             :.:||.:..| ..|:|....|.:|.....|.   |..|.:..|:  |...:|    |.||
 Worm   247 -SNQETPAKTKGAIEQSGLFLLTVPPVCPSTKGDYEDPSKIEHILSPYGKLLESPSTATLRFRKI 310

  Fly   290 GFFK-----------NLILNLPFKV---YSQDPSNRQSSLRPPPPPRPNDGPPGPELGSGNLFEP 340
            .|.|           :::|.:|.::   .::|.||...|....|.|.......|....:|    |
 Worm   311 PFLKVEYGIQVTLGTDILLEIPIEIGELSTRDKSNTLESFVTGPQPVEEADEKGKIAVNG----P 371

  Fly   341 AL--PVYPSLDSSIGSPSHSSQFSECSSINSITSDSS 375
            .:  ||||       .|.::....:.:|:..|:::.|
 Worm   372 FVYTPVYP-------YPQNAGTNGKAASVTVISTEPS 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	39/153 (25%)
		Arrestin_C	191..308	CDD:214976	32/152 (21%)
arrd-25	NP_510338.1	Arrestin_N	11..152	CDD:451447	39/155 (25%)
		Arrestin_C	179..336	CDD:214976	38/164 (23%)