Protein Alignment Leash and arrd-19

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_503917.1
• Gene: arrd-19 / 178764
• WormBaseID: WBGene00018061
• Length: 471
• Species: Caenorhabditis elegans
• Alignment Length: 528
• Identity: 117/528 - (22%)
• Similarity: 191/528 - (36%)
• Gaps: 141/528 - (26%)

  Fly     1 MESERLRITLDSADRVYFAGDIIRGEIWMNVNK-RTKIRAIKVQVTGKGKCKWMEILRKNSNNNE 64
            |....|.:..:..|.|:..|..|.|.:.::..| :.|.||:.:::.|.....|.:..|....|.|
 Worm     1 MPDTELHVIFNQPDEVFHPGKPISGRVVLSTTKEKYKARAVNIKILGLAHTSWTDTERVRKVNAE 65

  Fly    65 YSRSLFYTSKEVYEHSETPLPDFEPR----------------GLELSAGEHTFIFEVALGRQLPS 113
                    .||.|   ||.:.::...                ..||:|||:.:.|...|...:|.
 Worm    66 --------GKETY---ETKIVNYSANVNYLDYSLLLWASSDGSNELAAGEYAWPFSYTLPINVPP 119

  Fly   114 SFKGSYGAIKYKMRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTIS--LFGT 176
            ||:|.||.::|.:...|.|||..|:......||...:.|..:..:: :.:..|.::.:.  .|..
 Worm   120 SFEGKYGYLRYSVTAEIDRPWRVDKDKKRCITVSPLIDLNVIPHAL-TQINDQASENLGCCCFTK 183

  Fly   177 RPITLLALLPEDFAVRGEPLRICATVINNSTTAVEKLRFTVLQ---YVTYYSHVPLRVQKVECIA 238
            ..:.|...:|:...|.||.:.:...::|:|:..|.|::..::|   ::.|.:...:....    .
 Worm   184 GYLELRVNIPKTGFVPGETVPMNIHILNHSSVPVTKVKAKIIQQCKFIAYRNGTTVTYDG----G 244

  Fly   239 VATKETGSVQK-------------------KTERSFAHELLLPDGAQPTDEQMSGVITIVY--EL 282
            ..|..:|.:|:                   :.|..||.||.|| ...||..|.|.|||:.|  :.
 Worm   245 YETSTSGMLQETQHDTRTVVKQGLEMKVAPRNEHKFAMELRLP-SVTPTINQFSPVITVEYIVQF 308

  Fly   283 RVE-------------AVLRGFFKNLILNLPFKVYSQDPSNRQSSLRPPPPPRPNDG-------- 326
            .||             ::|.|... :...||...|.|||:      .||..|.|..|
 Worm   309 HVETSTTCGGNVDCEMSILIGTVP-ISKYLPPAYYPQDPN------LPPSQPTPIGGGVAPAGVA 366

  Fly   327 ------PP---------GPELGSGNLFEPALPVYPSLDSSIGSPSHSSQFSECSSINSITSDSSA 376
                  ||         |.:.|:|:...|..|.||   |.:.:|..|..           .....
 Worm   367 PAGVVPPPGYGFLPMTDGTDNGAGDTPYPVGPPYP---SDVPAPYPSGD-----------EPKDG 417

  Fly   377 ATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSSPLMVQSYP-----PPH 436
            ..:.|:      ...:||    :.|.||:.....:...:..|:.|         .||     |.:
 Worm   418 TVVVPS------APPLSY----EESMYGTEGTELNTDENAQPFAP---------KYPVFNDLPVY 463

  Fly   437 LPAYPPPE 444
            .|..||||
 Worm   464 NPTAPPPE 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	41/162 (25%)
		Arrestin_C	191..308	CDD:214976	35/153 (23%)
arrd-19	NP_503917.1	Arrestin_N	6..159	CDD:425619	41/163 (25%)
		Arrestin_C	182..332	CDD:214976	33/154 (21%)
		PHA03247	<338..470	CDD:223021	35/170 (21%)