Protein Alignment Leash and arrd-13

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_496882.1
• Gene: arrd-13 / 175022
• WormBaseID: WBGene00011054
• Length: 460
• Species: Caenorhabditis elegans
• Alignment Length: 516
• Identity: 114/516 - (22%)
• Similarity: 195/516 - (37%)
• Gaps: 128/516 - (24%)

  Fly     1 MESERLRITLDSADRVYFAGDIIRGEIWMNVNK-RTKIRAIKVQVTGKGKCKW--MEILRK---N 59
            |....|.:..|..:.|:|.|..|.|.:.::..| :.|.||:.:::.|.....|  .|.:|:   :
 Worm     1 MPETELHVIFDQPNEVFFPGQPISGRVVLSTTKEKYKARAVNIKILGLAHTSWTDYESVRRVDAD 65

  Fly    60 SNNNEYSRSLFYTSKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKY 124
            ...:.:.:|:.|::...|......|...:....||:|||:.:.|...|...:|.||:|.||.::|
 Worm    66 GKVSHHRQSVHYSANVNYLDYTLLLWACKDGSNELAAGEYAWSFSYNLPLNVPPSFEGKYGYLRY 130

  Fly   125 KMRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTIS--LFGTRPITLLALLPE 187
            .:...:.|||..|:......||...:.|..:..:: :.:..|.::.:.  .|....:.|...:|:
 Worm   131 SVTAEVDRPWRLDKAKKRCITVSPLIDLNVIPHAL-TQINDQASENLGCCCFKKGYLELRVNIPK 194

  Fly   188 DFAVRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATK---------- 242
            ...|.||.:.:...::|:|:..|.:::..::|               :|..:|.:
 Worm   195 TGFVPGETVPMNIHILNHSSVPVTEVKAKIIQ---------------QCKFIAYRNGTTFHYGGG 244

  Fly   243 -ETG----------------------SVQKKTERSFAHELLLPDGAQPTDEQMSGVITIVYELRV 284
             |||                      :|..:.|..||.||.|| ...||..|.|.|||:.|.::.
 Worm   245 YETGMSGQLQETKHDTKTVVKHGQEMTVAPRNEHKFAMELRLP-SVTPTINQFSPVITVEYIVQF 308

  Fly   285 EAVLRGFFKN--------LILNLPFK------VYSQDPSNRQSSLRPPP------PPRPNDG--- 326
            .......|.:        ||..:|.:      .|.|||:..|  :.|.|      .|.|..|
 Worm   309 HVETSSTFGSDVDCEMGILIGTVPIRQFLPPAYYPQDPNLPQ--ILPTPIGGGVVAPPPGYGFLP 371

  Fly   327 -PPGPELGSGNLFEPA--LPVYPSLDSSIGSPSHSSQFSECSSINSITSDSSAATLSPAVGAGTG 388
             ..|.|.|:|:...||  :|:||.  .::..||               .|.....:..|
 Worm   372 MADGSEKGAGDASYPAASMPMYPI--PNVPYPS---------------KDDGTVVIPSA------ 413

  Fly   389 GMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSSPLMVQSYP-----PPHLPAYPPPE 444
             ..:||    :.|.:|......:...:..|:.|         .||     |.:.|..||||
 Worm   414 -PPLSY----EESMFGQDGTELNTDENEQPFAP---------KYPVFNNLPVYNPTAPPPE 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	39/151 (26%)
		Arrestin_C	191..308	CDD:214976	34/163 (21%)
arrd-13	NP_496882.1	Arrestin_N	6..159	CDD:425619	39/152 (26%)
		Arrestin_C	182..332	CDD:214976	33/165 (20%)