Protein Alignment Leash and arrd-7

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_496567.2
• Gene: arrd-7 / 174847
• WormBaseID: WBGene00012464
• Length: 419
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 112/562 - (19%)
• Similarity: 176/562 - (31%)
• Gaps: 204/562 - (36%)

  Fly     6 LRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWME---ILRKN-------- 59
            |||..|:.:.|||.|..:.|::.:...:..|.|.:|:.:.|.....|.|   ..|.|
 Worm     4 LRIEYDAPNDVYFPGQAVTGKVIIQNREWIKARFLKICIHGGAHTHWSESRSTYRTNTRGERERF 68

  Fly    60 SNNNEYSRSLFYTSKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKY 124
            :.|..|:.::.|.:.|..........|      .|.||.:.|.|...|......||:|.:|.|:|
 Worm    69 TENVNYNATINYLTGESIAWQSRDGTD------RLPAGTNVFPFAFNLPINCAPSFEGCHGHIRY 127

  Fly   125 KMRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDF 189
            .:.|.:.|||.|:::....|:|:....|.....:|...:......|..:.....:|:...||:..
 Worm   128 DVHVELDRPWKFNKKSRKCFSVIPVFDLNITPTAINPMVNTASKNTGLILKKGLVTITVNLPKRG 192

  Fly   190 AVRGEPLRICATVINNSTTAVEKL--RFTVLQY----------VTYYSHVPLRVQKVECIAVATK 242
            .|.||.:.|...:.|.|..||.::  :.|.|.:          ||.::|
 Worm   193 YVAGEIMPITVNIDNGSKVAVSEVSAKMTQLSHFHASHGNMIGVTAHTH---------------- 241

  Fly   243 ETGSVQKKTERSFAHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPF------ 301
                 .:..|:..|....:.|....:..||      |..:::.|::..|      |.|.
 Worm   242 -----NRNDEKLVAESRRVADVPAKSRGQM------VLSMKIPAIVPSF------NCPIIAVDYC 289

  Fly   302 ---KVYSQDPSNRQSSLRPP------PPPRPNDGPPGPELGSGNLFEPALPVYPSLDSSIGSPSH 357
               ||.:|...........|      |..:.|...||           |:|..|    |:.:|.:
 Worm   290 LTVKVSTQQIFGGGLKCEFPLIIGTIPIRQMNQAAPG-----------AMPTMP----SVSAPPY 339

  Fly   358 SSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPY 422
                                   |.|            :|:.:||...|:|
 Worm   340 -----------------------PVV------------AGASASQAVYPTA-------------- 355

  Fly   423 SSSPLMVQSYPPPHLPAYPPPESPQYSLLALTPPPAGVVAAPPTGGAAAGGA------------- 474
                           |:.||..            |.|  .|||:...:..||
 Worm   356 ---------------PSAPPAS------------PGG--EAPPSYEESVHGAGKVEDAEAFAPRY 391

  Fly   475 PAYSQLPSTSASASFLQPRQAPGAHELPPSYEELFGLANAPP 516
            |.|:.||....|             :|||.|        |||
 Worm   392 PVYNNLPQQQNS-------------QLPPEY--------APP 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	41/156 (26%)
		Arrestin_C	191..308	CDD:214976	26/137 (19%)
arrd-7	NP_496567.2	Arrestin_N	4..156	CDD:425619	41/157 (26%)
		Arrestin_C	178..316	CDD:214976	30/170 (18%)
		PRK12323	<316..>415	CDD:481241	38/211 (18%)