Protein Alignment Leash and TXNIP

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_006463.3
• Gene: TXNIP / 10628
• HGNCID: 16952
• Length: 391
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 85/378 - (22%)
• Similarity: 155/378 - (41%)
• Gaps: 57/378 - (15%)

  Fly     8 ITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYT 72
            :..:..::||.:|:.:.|.:.:.|.:.|:::|:::...|..|..||:..::....:||.|
Human    12 VVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLR----- 71

  Fly    73 SKEVYEHSETPLPDFEPRG----LELSAG---EHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLI 130
                ||  :|.|.:.:|.|    :.:..|   |:.|.||:..| .|.:||||.||.:.|.::..:
Human    72 ----YE--DTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQG-PLGTSFKGKYGCVDYWVKAFL 129

  Fly   131 QRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFAVRGEP 195
            .||....:.....|.||..:.:.......|.|.:|:...:........:::.|.:.......|:.
Human   130 DRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDE 194

  Fly   196 LRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRV--QKVECIAVATKETGSVQKKTERSFAHE 258
            :.|.|...|..:..|......|.:: ||.::...:|  ||:..:......:|:......:|...:
Human   195 ISIHADFENTCSRIVVPKAAIVARH-TYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQ 258

  Fly   259 LLLPD--GAQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDP-SNRQSS------ 314
            .:.|.  |.        .::.:.|.|.:...:.| .|.:||:||..:.|:.. |:|.||
Human   259 KIRPSILGC--------NILRVEYSLLIYVSVPG-SKKVILDLPLVIGSRSGLSSRTSSMASRTS 314

  Fly   315 -------LRPPPPPRPNDGPPG-----PELGSGNLFEPALPVYPSLDSSIGSP 355
                   |..|..|   :.||.     ||  ...|..|..|:...:|.|..||
Human   315 SEMSWVDLNIPDTP---EAPPCYMDVIPE--DHRLESPTTPLLDDMDGSQDSP 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	39/150 (26%)
		Arrestin_C	191..308	CDD:214976	24/120 (20%)
TXNIP	NP_006463.3	Arrestin_N	10..152	CDD:451447	39/151 (26%)
		Arrestin_C	174..298	CDD:460676	24/133 (18%)