Protein Alignment Leash and Arrdc3

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001036056.1
• Gene: Arrdc3 / 105171
• MGIID: 2145242
• Length: 414
• Species: Mus musculus
• Alignment Length: 407
• Identity: 96/407 - (23%)
• Similarity: 169/407 - (41%)
• Gaps: 75/407 - (18%)

  Fly    11 DSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYTSK- 74
            ||...||.:||.:.|.:.:.|....:::::|:...|..|.:|.| .|...:|..|:::  ||.:
Mouse    18 DSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTE-SRNAGSNTAYTQN--YTEEV 79

  Fly    75 EVYEHSETPL-----PDFEPRGLE-LSAGEHTFIFEVALGR-QLPSSFKGSYGAIKYKMRVLIQR 132
            |.:.|.:..:     .|....|.. :.:|.|.:.|...|.: .|.:||:|.:|:::|.::..:.|
Mouse    80 EYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHR 144

  Fly   133 PWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFAVRGEPLR 197
            ||....:....|||.:::.:.......|.:..|:.|.......:.||:|.|.:.......||.::
Mouse   145 PWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQ 209

  Fly   198 ICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSFAHELLLP 262
            |.|.:.|.|:..|.. :..:.|...:|:...::..| :.:|....|:.| ..|||......|.:|
Mouse   210 IFAEIENCSSRMVVP-KAAIYQTQAFYAKGKMKEVK-QLVANLRGESLS-SGKTETWNGKLLKIP 271

  Fly   263 DGAQPTDEQM--SGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDP----SNRQSSL------ 315
                |....:  ..:|.:.|.|.|...:.|.. :|:|:||. |....|    .:|.||:
Mouse   272 ----PVSPSILDCSIIRVEYSLMVYVDIPGAM-DLLLSLPL-VIGTIPLHPFGSRTSSVSSQCSM 330

  Fly   316 -----------RPPPPP----------RPNDGPPGPELGSGNLFEPAL----------------P 343
                       ||..||          |.|:..|   :|:.:.||.||                |
Mouse   331 SMNWLALALPERPEAPPSYAEVVTEEQRRNNLAP---VGACDDFERALQGPLFAYIQEFRFLPPP 392

  Fly   344 VYPSLDSSIGSPSHSSQ 360
            :|..:|.   :|..||:
Mouse   393 LYSEIDP---NPDQSSE 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	38/148 (26%)
		Arrestin_C	191..308	CDD:214976	29/118 (25%)
Arrdc3	NP_001036056.1	Arrestin_N	22..165	CDD:425619	36/145 (25%)
		Arrestin_C	187..314	CDD:214976	33/135 (24%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..414		5/17 (29%)