Protein Alignment Leash and txnip

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_002938510.2
• Gene: txnip / 100492126
• XenbaseID: XB-GENE-968442
• Length: 388
• Species: Xenopus tropicalis
• Alignment Length: 375
• Identity: 87/375 - (23%)
• Similarity: 154/375 - (41%)
• Gaps: 53/375 - (14%)

  Fly     8 ITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYT 72
            ::.....:||..|:.:.|::.:.|.:.|::.|::|...|..|..|.:..::..   ||.|  |..
 Frog    12 VSFADPQKVYCGGEKVTGKVLVEVAEVTRVTAVRVLACGVAKVLWSQNCKQEM---EYLR--FED 71

  Fly    73 SKEVYEHSETPLPDFEPRGLELSAG---EHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRPW 134
            :.::.|.     |......:.:..|   |:.|.||:..| .|.|||||.||::||.::..:.||.
 Frog    72 TLQMEEQ-----PTDSDGSVIMRPGNFYEYKFGFELPQG-PLGSSFKGKYGSVKYWVKAFLDRPS 130

  Fly   135 TFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFAVRGEPLRIC 199
            ...:.....|.|..::.:.......|.|.:|....|........|::.|.:.......||.:.|.
 Frog   131 HPPQEAQKHFQVEDSVNVDTPDLMSPVSGKKYKKMTCMFIPDGHISMSACINRKGFCEGEDICIS 195

  Fly   200 ATVINNSTTAVEKLRFTVLQYVTYYSHVPLRV--QKVECIAVATKETGSVQKKTERSFAHELLLP 262
            |. ..|:.:.:...:..::...||.::...:|  ||: |   :.:....:...|:......:.:|
 Frog   196 AD-FENTCSRIVVPKAAIISKHTYLANGQTKVFTQKL-C---SVRGNHIISGMTDSWRGKSIRVP 255

  Fly   263 DGAQPTDEQMSG--VITIVYELRVEAVLRGFFKNLILNLPFKVYSQDP--SNRQSS--------- 314
            . .:|:   :.|  ::.:.|.|.|...:.| .|.:|||||..:.|...  ::|.||
 Frog   256 K-IKPS---ILGCNILRVEYSLLVYVSVPG-AKKIILNLPLVIGSSSSGMNSRTSSMASQASSEM 315

  Fly   315 ----LRPPPPPRPNDGPPG-----PELGSGNLFEPALPVYPSLDSSIGSP 355
                |..|..|   :.|||     ||  ...|..|..|:...||.:..||
 Frog   316 SWIELNIPGTP---EAPPGYLDIVPE--DHRLESPTTPLLDDLDGACDSP 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	37/146 (25%)
		Arrestin_C	191..308	CDD:214976	26/120 (22%)
txnip	XP_002938510.2	Arrestin_N	10..142	CDD:451447	36/140 (26%)
		Arrestin_C	172..296	CDD:214976	27/133 (20%)
		Periplasmic_Binding_Protein_Type_2	<336..>370	CDD:473866	9/27 (33%)