DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad86C and PCDH7

DIOPT Version :10

Sequence 1:NP_001247033.1 Gene:Cad86C / 41302 FlyBaseID:FBgn0261053 Length:1949 Species:Drosophila melanogaster
Sequence 2:NP_001166994.1 Gene:PCDH7 / 5099 HGNCID:8659 Length:1255 Species:Homo sapiens


Alignment Length:1133 Identity:234/1133 - (20%)
Similarity:413/1133 - (36%) Gaps:302/1133 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   306 SETTEG----TVFLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVF 366
            ::|.:|    .:.:.|.||.|::..|.||:...|. .:|.:.|:.|    :.|::.||.|..|.|
Human   249 ADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDG-GDPPRSSQAI----LRVLITDVNDNSPRF 308

  Fly   367 TSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPL 431
            ..:.....|.....||..|||:.|.|.|.|...::.|...:..........::||||.:.::..:
Human   309 EKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRI 373

  Fly   432 --EDIAFITHVGDPVLLTVIAEEVKVGRDEPPAL-ASTVQLAFFLPDRTNSPPYFE--------- 484
              |::       :.:..||:|.:    |.:||.. .:||.|.  :.|..::.|..|         
Human   374 DREEV-------NQLRFTVMARD----RGQPPKTDKATVVLN--IKDENDNVPSIEIRKIGRIPL 425

  Fly   485 NDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAG--- 546
            .|. |:.|.|:....|.:..|     :|.|.|.|:|||.:.|:: .:..|::.|  |..:.|   
Human   426 KDG-VANVAEDVLVDTPIALV-----QVSDRDQGENGVVTCTVV-GDVPFQLKP--ASDTEGDQN 481

  Fly   547 ----FLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSV 607
                ||   ..::.||||..:.....|:|.:.| :.:||:..::.|.:.|.|||.|:|.|....|
Human   482 KKKYFL---HTSTPLDYEATREFNVVIVAVDSG-SPSLSSNNSLIVKVGDTNDNPPMFGQSVVEV 542

  Fly   608 ELPENMTAGTKVVQVLATDPDSGLGGKVRY---TAILGYLNTSLNLDAETGLITVSTNKHGFDRE 669
            ..|||...|.:|..|||||.|||...::.|   ::::|.    ..:|.::|.|.|:|   ..|||
Human   543 YFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGI----FAIDPDSGDILVNT---VLDRE 600

  Fly   670 VMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAED 734
            ....|...|.|:|......:....:|:::.|.||..|.|.:|::.|.:..:|...:...::...|
Human   601 QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMD 665

  Fly   735 KDATAPNNEVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFI 799
            .| ...|.|:...|...|  |.|.::..||  |:...:..                |.|....:.
Human   666 AD-KGRNAEMSLYIEENN--NIFSIENDTG--TIYSTMSF----------------DREHQTTYT 709

  Fly   800 LTARAYDLGVPVRFSTTTIRVY----------------------PPESRKRSVKFVVPGHNPDKA 842
            ...:|.|.|.|.|.:|.|:.::                      ||.|..|:|...|...:.|..
Human   710 FRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDG 774

  Fly   843 KTEETLSALSGGKVY-IHNIRPLSPDEPGAKD----------------IPAGNPGIKERSVVTAT 890
            ...:...::.||..: :..|.|.|    |...                :...:.|...:|..|..
Human   775 INADLNYSIVGGNPFKLFEIDPTS----GVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLV 835

  Fly   891 VIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFWLLILLATLVAL 955
            .::.:.||.:.:.|..:::  .:.:..:.||.:.       ...|:...:.|..::.::|.::.:
Human   836 HVFVNESVSNATAIDSQIA--RSLHIPLTQDIAG-------DPSYEISKQRLSIVIGVVAGIMTV 891

  Fly   956 TILILLLCCICSWC-----------------------------------------PLYGAATKRI 979
             |||:|:..:..:|                                         |||.:    |
Human   892 -ILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSS----I 951

  Fly   980 VNISRTEDDVHLVHREMANGKQTKSVQV----AEWMGR-RDAWSAEKPPDTR------------- 1026
            |.:..::          .||::..||..    :..||| |........||..             
Human   952 VTVEASK----------PNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQ 1006

  Fly  1027 ---TKPTRWEFHDGREQL---DEDVGRGQDIGEGD--------RRHIQSAEEQQRRVRIKHNRTA 1077
               ..||..:.|...:.|   :..||.|.:|..|.        :.:.:.:::..|||........
Human  1007 LHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQP 1071

  Fly  1078 KDDLHLNFHNSRTNLINDRDVYMEDVIENRDLAGDREHITRTRVNRQEYARRKQYDS--EVRHID 1140
            :|.     |........|..:...:...::..:|.|  :....:....|.|.....|  |..|::
Human  1072 QDP-----HQGSLQSCYDSGLEESETPSSKSSSGPR--LGALPLPEDNYERTTPDGSVGEAEHME 1129

  Fly  1141 DDSMRRHEIDRGSDIDFNTAHNSLKSKRELFIKDGNVEILQLMTRDKTRDGLNLDDDNIYVNVPL 1205
            :||                        |.|    .:|.:....||:....|   ..|:.::.|..
Human  1130 NDS------------------------RPL----PDVALTGKCTRECDEYG---HSDSCWMPVRT 1163

  Fly  1206 KPAGNLSHPQL---LMVDNTGKEILMRRFIEEQPDGKQII-------------REHYQIVPGATY 1254
            .|....|.|:|   :.||..|.:       |:..:|:..|             ...|:....|::
Human  1164 SPERKKSQPKLSTFMPVDERGSQ-------EKLANGEAAIMGDRNRNLLNKKLTSSYETFSAASF 1221

  Fly  1255 I---QSMPNEVQQGSTLKGDTFPLGKSG 1279
            .   ::.|.::           ||.|:|
Human  1222 SKNEEANPEDI-----------PLTKTG 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad86CNP_001247033.1 Cadherin_repeat 260..361 CDD:206637 16/58 (28%)
Cadherin_repeat 372..469 CDD:206637 24/99 (24%)
Cadherin_repeat 487..596 CDD:206637 31/115 (27%)
Cadherin_repeat 605..703 CDD:206637 30/100 (30%)
Cadherin_repeat 728..820 CDD:206637 20/91 (22%)
PTZ00449 <1428..1918 CDD:185628
PCDH7NP_001166994.1 Cadherin_repeat 35..139 CDD:206637
Cadherin_repeat 147..304 CDD:206637 16/59 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..242
Cadherin_repeat 312..411 CDD:206637 26/111 (23%)
Cadherin_repeat 429..531 CDD:206637 31/113 (27%)
Cadherin_repeat 541..635 CDD:206637 31/100 (31%)
Cadherin_repeat 643..738 CDD:206637 22/115 (19%)
Cadherin_repeat 749..839 CDD:206637 16/93 (17%)
Protocadherin 842..1053 CDD:462451 37/234 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..988 13/91 (14%)
Blue background indicates that the domain is not in the aligned region.

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