Protein Alignment Cad86C and shg

DIOPT Version :10

• Sequence 1: NP_001247033.1
• Gene: Cad86C / 41302
• FlyBaseID: FBgn0261053
• Length: 1949
• Species: Drosophila melanogaster
• Sequence 2: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Alignment Length: 1500
• Identity: 293/1500 - (19%)
• Similarity: 469/1500 - (31%)
• Gaps: 572/1500 - (38%)

  Fly    82 HHHHHQQQHNHQNQQMQHHWPSRLGPIGPWLGAMTAYRLLTISLLIGILCPHHVQGADPKFDPTT 146
            |.:..|||.:.|:::.......||.|....||.:.|     ||||...|..|  ...|..|....
  Fly    25 HLNPAQQQTHQQHKRKCRDLGRRLIPARLLLGVIVA-----ISLLSPALALH--SPPDKNFSGDN 82

  Fly   147 RMRLVLVPADAQVNSVIYRLRATDEEFDYPLTFEFVGDASASTVKVESLPCTKYNSVCQANIVLQ 211
            |.     ||.........:::....|..|.||.|.|.......:
  Fly    83 RK-----PAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQVI--------------------- 121

  Fly   212 RRLEPGRYYDFQVSVKDTKGGMTTQLCSITATNFTTPHDLIFPHKPGIIMIPEDAKRGTELDYVI 276
                  ||                   ||..:.|..|...|.| ..|:|.          ..:..
  Fly   122 ------RY-------------------SIVQSPFERPKFFINP-STGVIF----------TTHTF 150

  Fly   277 ARKNPLFQKPVYLELWGSPLFAIRQKIVSSETTEGTVFLLGPLDFEKQAMYHLTILANDAYAEPG 341
            .|..|:.:|.|::                  |.:.|...|.|||  ....:::||
  Fly   151 DRDEPIHEKFVFV------------------TVQATDNGLPPLD--DVCTFNVTI---------- 185

  Fly   342 QDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLV 406
                           :|:.|..|.|..|.....:.....|...::.:.|.|.|.||...|.|.::
  Fly   186 ---------------EDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEYEIL 235

  Fly   407 SENNPFTSFFDINETSGEIFLMRPL-----EDIAFITH----VGDP-------VLLTVIAEEVKV 455
            .|.:  ..:|.|::.||.|:|.||:     :..|.|..    |.||       |.:.|:...:|
  Fly   236 RERD--FQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIK- 297

  Fly   456 GRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKN 520
                ||:..:.:....:|.:...:   |.:.....|...|.|.       .|.|  :::.:||:.
  Fly   298 ----PPSFVNPIDTPIYLKENLKN---FTHPIATLRAVSNMPD-------KPEV--IFELNTGRT 346

  Fly   521 GVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQ---ELGPATNLSA 582
                 ...|:..||..:      ..|..:.:.....||||........::.:   |||...
  Fly   347 -----EQTNSKNTFVFN------QIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEH---- 396

  Fly   583 LVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTS 647
              .:.:.:.|||||.|.:.: ..|..:.||...||.|:||.|.|.|                .||
  Fly   397 --QIKIQVEDVNDNIPYYTE-VKSGTILENEPPGTPVMQVRAFDMD----------------GTS 442

  Fly   648 LN---------------LDAETGLITVSTNKHGFDREVMPEYHLYVEARDM-------DGEGNRA 690
            .|               :|..||.||..|.   ||||....|::.|.|.|.       :||.||.
  Fly   443 ANNIVSFELADNREYFTIDPNTGNITALTT---FDREERDFYNVKVIASDNSPSSLFDNGEPNRG 504

  Fly   691 QVPLIIKLIDVNDETPIFDKDLYEFILTHDLM--GFTTTAVIH--AEDKDATAPNNEVRYEIING 751
            .....|.:.|.||..|.|.:|.|   |...|:  ..|.|.||.  |||:|..   :::.|.|.:|
  Fly   505 HQVFRISIGDKNDHKPHFQQDKY---LAERLLEDANTNTEVIEVKAEDEDNA---SQILYSIESG 563

  Fly   752 NYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFSTT 816
            |..:.|.:...||::||.:|:                  |.|....:.|..||:| |:...::|.
  Fly   564 NVGDAFKIGLKTGKITVNQKL------------------DYETITEYELKVRAFD-GIYDDYTTV 609

  Fly   817 TIRVYPPESRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIHNIRPLSPDEPGAKD----IPAG 877
            .|::.....            ||...|.:.:::.|               :|....|    :.|.
  Fly   610 VIKIEDVND------------NPPVFKQDYSVTIL---------------EETTYDDCILTVEAY 647

  Fly   878 NPGIKERSVVTATVIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVL 942
            :|.||:|:.       |...|..|        |.|:.                  .::..:|
  Fly   648 DPDIKDRNA-------DQHIVYSI--------HQNDG------------------NRWTIDN--- 676

  Fly   943 FWLLILLATLVALTILILLLCCICSWCPLYGAATKRIVNISRTEDDVHLVHREMANGKQTKSVQV 1007
                                    |.|          :.:.:|.|      |:..||.:...|.:
  Fly   677 ------------------------SGC----------LRLVKTLD------RDPPNGHKNWQVLI 701

  Fly  1008 AEWMGRRDAWSAEKPPDTRTKPTRWEFHDGREQLDEDVGRGQDIGEGDRRHIQSAEEQQRRVRIK 1072
                                           :..||| |.|..:            ...:.|.:
  Fly   702 -------------------------------KANDED-GVGTTV------------STVKEVTV- 721

  Fly  1073 HNRTAKDDLHLNFHNSRTNLINDRDVYMEDVIENRDLAGDREHITRTRVNRQEYARRKQYDSEVR 1137
               |.||     .:::...|||:..||.:   |||:..    |:.:.:.|  :|
  Fly   722 ---TLKD-----INDNAPFLINEMPVYWQ---ENRNPG----HVVQLQAN--DY----------- 758

  Fly  1138 HIDD-----------DSMRRHEIDRGSDIDFNTAHNSL----KSKRELFI----------KDGNV 1177
              ||           ||....:|.....:|.:..|.::    ::::|.||          :...|
  Fly   759 --DDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAV 821

  Fly  1178 EILQLMTRDKTRDGLNLDDDNIYV-----NVPLKPAG--------------------NLSHPQLL 1217
            .||.|:..|...:.::.....|::     ..|....|                    :|.|.|..
  Fly   822 SILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFR 886

  Fly  1218 MVDNTGKEILMRRFIEEQPDGKQIIREHYQIVPG-------ATYIQSMPNEVQQGSTLKGDTFPL 1275
            :..:||...::....|.:.|...::.|....||.       ...::.:|.|.            :
  Fly   887 LNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEA------------V 939

  Fly  1276 GKSGPNSIVYSQLEPEVKVIHTQPVQAGEGVSLDQQMQ--------PAVSN-------QSLTHEL 1325
            .|||  ||.:..:..|..:...:..|:.:.:||..::|        .:|||       |:..|.|
  Fly   940 DKSG--SIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTL 1002

  Fly  1326 ----------------------EHSLKQQNALLRQILM--------EKEKLENAYTQ--HEVAL- 1357
                                  ::..:.:|.|..|:||        ||.|.|.:.|.  |:.::
  Fly  1003 DVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVP 1067

  Fly  1358 -----ETQSLPGQSMAIGTQTDCDAGTQTEGFDGVLDPEISLAKPSRRRARS-------ENDESM 1410
                 .|.|..|.:..:..|..|:|                   |..||..:       |||...
  Fly  1068 YMIYSNTTSFVGVNAFVQAQCVCEA-------------------PLMRRCLNGGSPRYGENDVCD 1113

  Fly  1411 SEDGY 1415
            ..||:
  Fly  1114 CIDGF 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	14/100 (14%)
		Cadherin_repeat	372..469	CDD:206637	27/112 (24%)
		Cadherin_repeat	487..596	CDD:206637	21/111 (19%)
		Cadherin_repeat	605..703	CDD:206637	34/119 (29%)
		Cadherin_repeat	728..820	CDD:206637	25/93 (27%)
		PTZ00449	<1428..1918	CDD:185628
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	29/199 (15%)
		Cadherin_repeat	200..292	CDD:206637	23/93 (25%)
		CA	332..410	CDD:214520	21/103 (20%)
		Cadherin_repeat	417..518	CDD:206637	35/119 (29%)
		Cadherin_repeat	531..619	CDD:206637	28/121 (23%)
		Cadherin_repeat	627..729	CDD:206637	31/245 (13%)
		Cadherin_repeat	736..834	CDD:206637	23/119 (19%)
		LamG	1127..1294	CDD:238058
		CADH_Y-type_LIR	1430..1489	CDD:460041