DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad86C and Cdhr2

DIOPT Version :10

Sequence 1:NP_001247033.1 Gene:Cad86C / 41302 FlyBaseID:FBgn0261053 Length:1949 Species:Drosophila melanogaster
Sequence 2:NP_001028536.2 Gene:Cdhr2 / 268663 MGIID:2687323 Length:1308 Species:Mus musculus


Alignment Length:937 Identity:224/937 - (23%)
Similarity:359/937 - (38%) Gaps:217/937 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 WLGAMTAYRLLTISLLIGILCPHHVQGADPKFDPTTRMRLVLVPADAQVNSVIYRLRATDEEFDY 175
            ||..:.|   |..:.::.:     ...:.|.|.  ..|.||.:|.|..|.:|.:.|.|||.:.|:
Mouse     3 WLWLLCA---LLPAFMVSV-----TANSPPSFG--VNMTLVTLPEDLPVGAVAFWLVATDSDNDH 57

  Fly   176 PLTFEFVG-DAS-------------ASTVKVESLPCTKYNSVCQANIVLQRRLEPGRYYDFQVSV 226
             ||:...| :||             ||.:..|::|..|........:.:       |..:.||.|
Mouse    58 -LTYGISGPNASYFSVNANTGEVKLASPLDFETVPFFKITISTSDGLNI-------RTAEMQVIV 114

  Fly   227 KDTKGGMTTQLCS--ITATNFTTP-HDLIFPHKPGIIMIPEDAKRGTE--LDYVI-------ARK 279
            :|....:...|.:  .|:.|.|.| ..::|.      ::.||...||.  :.|.|       |..
Mouse   115 EDRNDNIPVFLNTEFSTSINETLPVGSVVFS------VLAEDKDTGTAGLVQYFIEKVIPSTANS 173

  Fly   280 NPLFQKPVYLELWGSPLFAIRQKIVSSETTEGTVFLLGPLDF-EKQAMYHLTILANDAYA----E 339
            |.||:   .||                   .|::.|...|.: .|.|.|.|.:.|.|:..    :
Mouse   174 NNLFR---ILE-------------------NGSIVLNDTLSYNNKSAFYQLELKACDSGGILDNK 216

  Fly   340 PGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYG 404
            |.........:.|.||  |..|..|.|........:......|..:|.|.|.|.|||....|.|.
Mouse   217 PKTQCSQPVFVSISVI--DEPDLDPRFIREFYSASVAEDATLGTSVLTVEAVDSDKGINDIVTYS 279

  Fly   405 LVSENNPFTSFFDINETSGEIFLMRPLEDIAFITHVGDPVLLTVIAEEVKV---GRDEPPALAST 466
            :.:...|  .:|||.| .|.||:...|:....:.. .:.|.:.|.|.|..:   |::...::..|
Mouse   280 VSNSTRP--GWFDIRE-DGVIFVNGSLDREQLLLE-NEEVQIQVTATEKNLNIYGQEAKASMWVT 340

  Fly   467 VQLAFFLPDRTNSPPYFEN--------------DHYVSRVDENAPHGTALTFVDPYVPRVYDDDT 517
            :::.    |..:..|.|.|              .:::..|||   |.:|...:|......||.|.
Mouse   341 IRVT----DVNDHKPEFYNCSLPGCSFSPQEAQVNFIGYVDE---HASARISIDGLTMVAYDPDQ 398

  Fly   518 GKNGVFSLTLLNNNG----TFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQELGPAT 578
            |.||.|.|:|   ||    .|.:||..|..|....:.||::.|:|||::..:..:::|.:  ..:
Mouse   399 GDNGTFLLSL---NGQDAEAFNVSPERAAGSVSVQVVVRNSEMVDYEKETVMVVEVVATD--SVS 458

  Fly   579 NLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVV-QVLATDPDSGLGGKVRYTAILG 642
            |..::..||:::.::||:.|||.|..|.:.:||:...|..|. ::.|||.|....|.:.|:.:.|
Mouse   459 NNYSVATVTIHLRNINDHRPVFSQSLYELTVPEHCPTGYLVTDKIQATDLDGDEWGPITYSLLPG 523

  Fly   643 YLNTSLNLDAETGLITVSTNKHG--FDREVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDET 705
            .......::..:|.:||   |:|  .|||....|:|.::|  .||........|.|.|:|:||..
Mouse   524 NGADLFEVEPNSGNLTV---KNGTLLDREKQAVYYLTLQA--TDGGNQSTTTALEITLLDINDNP 583

  Fly   706 PIFDKDLYEFILTHDLMGFTTTAVIHAEDKDATAPNNEVR-YEIINGNYDNQFVLDKVTGELTVR 769
            |:. :..|...:..:....:.|  |.|.|.|....||.:. :.::.|.|.:.|.||..||.|   
Mouse   584 PVV-RGSYNVFVPEENGNVSVT--IQAYDDDQPDTNNSLLVFSLLPGPYSSNFSLDPNTGLL--- 642

  Fly   770 EKIHLRSKKNAKTRRRRQAGSDDEDT------DIFILTARAYDLGVP-------VRFSTTTIRVY 821
                            |..|..|.:.      ...:||....|.|.|       |..:...|...
Mouse   643 ----------------RNLGPLDREAIDPALEGRIVLTVIVADCGEPSLSTNVNVTITVEDINDN 691

  Fly   822 PP---ESRKRSVKFVVPG--------HNPDKAKTEETLS-ALSG---------GKV--------- 856
            .|   :|.:.||...|||        .:.|:......:| :|||         |.|         
Mouse   692 LPVFNQSYEFSVWERVPGAWVGTVKAWDADQTAANNRISFSLSGTGANNFILQGNVLEQGWAEGS 756

  Fly   857 --YIHNIR-----------PLSPDEPGAKDIPAGNPGIKERSVVTATV--IYDSSSVVDISEIQ- 905
              .:.::|           .:|.:.||.:       |:...:.||.||  :.|....:|.:.:| 
Mouse   757 LWLLPDVRLDYETQKFFHLTVSAENPGPQ-------GLDSTANVTVTVMDVNDEPPTLDAASLQA 814

  Fly   906 ----QRLSHHNNSYAIMPQDTSSTDTL 928
                :..|.|.....::.||..:...|
Mouse   815 ISVTENGSEHGQVTRVIAQDVDTAALL 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad86CNP_001247033.1 Cadherin_repeat 260..361 CDD:206637 26/114 (23%)
Cadherin_repeat 372..469 CDD:206637 25/99 (25%)
Cadherin_repeat 487..596 CDD:206637 33/112 (29%)
Cadherin_repeat 605..703 CDD:206637 29/100 (29%)
Cadherin_repeat 728..820 CDD:206637 24/105 (23%)
PTZ00449 <1428..1918 CDD:185628
Cdhr2NP_001028536.2 Cadherin_repeat 33..120 CDD:206637 25/94 (27%)
Cadherin_repeat 128..236 CDD:206637 31/137 (23%)
Cadherin_repeat 246..349 CDD:206637 26/110 (24%)
Cadherin_repeat 372..476 CDD:206637 33/111 (30%)
Cadherin_repeat 485..582 CDD:206637 30/101 (30%)
Cadherin_repeat 589..691 CDD:206637 26/122 (21%)
Cadherin_repeat 698..802 CDD:206637 22/110 (20%)
Cadherin_repeat 815..923 CDD:206637 5/27 (19%)
Cadherin_repeat 934..1042 CDD:206637
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9BYE9 1178..1308
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1251..1308
Blue background indicates that the domain is not in the aligned region.

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