Protein Alignment Cad86C and pcdh1a

DIOPT Version :10

• Sequence 1: NP_001247033.1
• Gene: Cad86C / 41302
• FlyBaseID: FBgn0261053
• Length: 1949
• Species: Drosophila melanogaster
• Sequence 2: XP_001345220.4
• Gene: pcdh1a / 100006496
• ZFINID: ZDB-GENE-091116-32
• Length: 1190
• Species: Danio rerio
• Alignment Length: 1229
• Identity: 253/1229 - (20%)
• Similarity: 445/1229 - (36%)
• Gaps: 329/1229 - (26%)

  Fly   159 VNSVIYRLRATDEEFDYPLTFEFVGDASASTVKVESLPCT-----------------KYNSVCQA 206
            |..::||:    .|...|.|  .:|..:|.    :.||.|                 |...:...
Zfish    22 VGGILYRV----HEEQPPST--LIGSLAAD----QGLPDTGHLYKLEVGAPYLRVDGKTGDIFTT 76

  Fly   207 NIVLQRRL-----EPGR--YYDFQVSVKDTKGGMTTQL----CSITATNFTTPHDLIFP------ 254
            .|.:.|..     ..|:  :.:|:|||.|.....:.:|    ..:...|..||.   ||
Zfish    77 EIPIDRETLKDCRNKGKPCFLEFEVSVTDLIQNQSPRLIEGRIEVQDINDNTPQ---FPSPVLTL 138

  Fly   255 ------HKPGIIMIP----EDAKRGTELDYVIARKNPLFQKPVYLELWGSPLFAIR-QKIVSSET 308
                  |...:..||    :|.:|....||.      |...|..:.|:|..:...| :|:..
Zfish   139 SVPENTHMGALFSIPLATDKDTERNGVADYT------LTAGPEAVALFGLQVAEDRGEKLPQ--- 194

  Fly   309 TEGTVFLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVT 373
                :.:||.||.|.:..|.|||.|.|....|...|..:.     |::.|..|..|.|..:....
Zfish   195 ----LIVLGSLDRELKDSYDLTIKAVDGGNPPRYSSALLR-----VVIADANDNAPKFEKSSYEA 250

  Fly   374 KLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLEDIAFIT 438
            ::......|..:|||.|.|.|.|...|:.|.|....:|......|:.:||.|::..||:
Zfish   251 EVAENSPIGHSVLQVKANDSDLGPNGEIEYTLHQAIDPVPKLLRIDRSSGIIYVKGPLD------ 309

  Fly   439 HVGDPVLLTVIAEEVK------VGRDEPPA-LASTVQLAFFLPDRTNSPPYFE--------NDHY 488
                       .||:.      |.||:.|: .:|...::..:.|:.::.|..|        :...
Zfish   310 -----------REEINNLKFYVVARDKGPSPKSSKTYVSIDVTDQNDNAPAVEIRGIGLVTHSDG 363

  Fly   489 VSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISP----NVAERSAGFLI 549
            |:.:.|:.|.|||:..|     :|.|.|.|:|.|.: .::..:..|::.|    :|..:...||
Zfish   364 VANISEDMPVGTAVALV-----QVSDKDEGENAVVT-CVVAGDVPFQLRPASDSSVDNKRKYFL- 421

  Fly   550 RVRDNSMLDYEQQQSVQFQILAQELG-PATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENM 613
              :..:.||||:.:..:.:|:|.:.| ||  ||:..::.|.:.|.|||:|:|....:.||..|..
Zfish   422 --QTTTPLDYERVRDYRVEIVAVDSGNPA--LSSTNSLKVQVTDTNDNSPIFSPTLFEVEFAEEN 482

  Fly   614 TAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAET-GLITVSTN------KHGFDREVM 671
            ..|.|||:|:|:|.|||...::.|:.|         .|:.| ||..:..|      :..||||..
Zfish   483 QPGEKVVEVVASDADSGTNAELVYSII---------ADSSTRGLFEIDPNSGEVRARSPFDREHK 538

  Fly   672 PEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKD 736
            ..|...|.|.|.....:|....::||::|.||..|.|....|.|.:..::...:...::..:|.|
Zfish   539 DRYEFRVTAADKGVPSHRGTATVVIKVLDRNDNDPKFMLSGYSFSVLENMPPLSPVGMVTVQDMD 603

  Fly   737 ATAPNNEVRYEIINGNYD-NQFVLDKVTGELTVREKIHL-RSKKNAKTRRRRQAGSDDEDTDIFI 799
             ...|.:|:..:   ..| .:||:...||  |:...|.. |.|:::.|.|.:.....|.....::
Zfish   604 -EGENAQVQLSV---EPDVGKFVIQNGTG--TILSSISFDREKESSYTFRLKAVDGGDPPRSSYV 662

  Fly   800 -LTARAYD----LGVPVRFSTTTIRVYPPESRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIH 859
             :|....|    ..|..:.|.::.....|.:...||..||...:.|.....|.:.:::||..  |
Zfish   663 GVTINVLDENDNAPVVTKPSNSSFIRLSPMAAPDSVVEVVEAEDIDSGSNAELVYSIAGGNP--H 725

  Fly   860 NIRPLSPDEPG---AKDIPAGNPGI------------KERSVVTATVIYDSSSVVDISEIQQRLS 909
            ::..:||....   .|::...:.|:            ..|..:....||.:.::.::|.::..:.
Zfish   726 DLFYISPSNGEITLTKELTRKHSGLHRLVIKVSDRGKPSRHAIALVHIYVNETIANVSHVEALVG 790

  Fly   910 HHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFWLLILLATLVALTILILLLCCICSWCPLYGA 974
            |  :.|..:..|.:. |....|..|   .:.:::..|..:|.:|.:.::::.:
Zfish   791 H--SLYTPLDMDIAG-DPDYGLAAQ---RSNIVYGSLAGVAGVVTVIVVVVFI------------ 837

  Fly   975 ATKRIVNISRTEDDVHLVHREMANG-----KQTKSVQVAEW---MGRRDAWSAEKPPDTRTKPTR 1031
                          .|.:.||..:|     |:||.:...:.   .|:.......|||.: .||..
Zfish   838 --------------RHRLQRETKSGYQAGKKETKDLYAPKQGPKSGKGRKGKKGKPPKS-PKPLG 887

  Fly  1032 WEFHDGREQLDEDVGRGQD-IGEGDRRHI----------------------------QSAEEQQR 1067
               .|....|.:.:....| :.:..|.|:                            ||....|:
Zfish   888 ---EDEEVSLQKSLKFNLDGVNDSPRIHLPLTYPPGSPDLGRHYRSNSPLPSIQLQAQSPSASQK 949

  Fly  1068 RVRIKH--------------NRTAKDDLHLNFHNSRTNLINDRDVYMEDVIENRDLAGDREHITR 1118
            ...::.              |.|..|  ..:.::.:||    :..|....:.:|       .:|.
Zfish   950 HQAVQELPAANTFVGTGGDDNSTGSD--QYSDYSYKTN----QPKYSTKTLPHR-------RVTF 1001

  Fly  1119 TRVN----RQEYARRKQYDSEVRHIDDDSMRRHEIDRGSDIDFNTAHNSLKSKRELFIKDGNVEI 1179
            :..|    :|:.:::..|||.:...:..|
Zfish  1002 STANPMQDQQDSSQQSYYDSGLEESETPS------------------------------------ 1030

  Fly  1180 LQLMTRDKTRDG-----LNLDDDNIYVNVPLKPAGNLSHPQ--------LLMVDNTGKE 1225
                  .|:..|     |.|.:|:.....|....|.:.||:        :.|..|..:|
Zfish  1031 ------SKSSSGPRIGPLALPEDHYERTTPDGSIGEMEHPETDIRSLPDVAMTGNCSQE 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	27/105 (26%)
		Cadherin_repeat	372..469	CDD:206637	25/103 (24%)
		Cadherin_repeat	487..596	CDD:206637	32/113 (28%)
		Cadherin_repeat	605..703	CDD:206637	32/104 (31%)
		Cadherin_repeat	728..820	CDD:206637	20/98 (20%)
		PTZ00449	<1428..1918	CDD:185628
pcdh1a	XP_001345220.4	Cadherin_repeat	27..127	CDD:206637	21/109 (19%)
		Cadherin_repeat	135..239	CDD:206637	28/121 (23%)
		Cadherin_repeat	247..346	CDD:206637	26/115 (23%)
		Cadherin_repeat	364..465	CDD:206637	32/111 (29%)
		Cadherin_repeat	474..571	CDD:206637	33/105 (31%)
		Cadherin_repeat	580..674	CDD:206637	20/99 (20%)
		Cadherin_repeat	693..775	CDD:206637	15/83 (18%)
		Protocadherin	778..989	CDD:462451	36/252 (14%)