Protein Alignment Cap-H2 and kle-2

DIOPT Version :10

• Sequence 1: NP_650014.2
• Gene: Cap-H2 / 41289
• FlyBaseID: FBgn0037831
• Length: 960
• Species: Drosophila melanogaster
• Sequence 2: NP_498727.2
• Gene: kle-2 / 176116
• WormBaseID: WBGene00016202
• Length: 821
• Species: Caenorhabditis elegans
• Alignment Length: 967
• Identity: 193/967 - (19%)
• Similarity: 340/967 - (35%)
• Gaps: 278/967 - (28%)

  Fly    24 IAKNRPGTQVAKCIRAYDEQQDLASLVVLLEELSKNTDYSTDLRISLGYYIEELLRHCLGRN--- 85
            :.:|.|..|         |..|||.||...::|.:|  :|.|:..:|..|:|.:.:.....:
 Worm     1 MTRNAPPGQ---------ESTDLAWLVTPAKDLVEN--FSIDVLKALAGYLEVIRQESEDTDNQV 54

  Fly    86 ---------DVSRRSAIVAAGSALQYCGKIYGDRVEYLCQVVEHQIEALLTSELQKETPSGSAAP 141
                     |..|...|:....|      :||.:|:::.::....:: |:.::.|.:..:||
 Worm    55 DAATTYRLFDFQRACRIIQGSCA------VYGRKVDHVYELTISVVD-LVENKGQDDGNTGS--- 109

  Fly   142 EKNERRPEETRKRHPKKLTN---KEVDPY----LLTLEPKRFKTMSDDKRFNAAGFVKCTRN-RT 198
                ||....||......||   .::|..    |...|    ||:.::|:  :...|:...| ..
 Worm   110 ----RRGAGRRKNFNLGSTNYDLADIDSLKQEALANFE----KTVKEEKK--SIDAVRMVENAEV 164

  Fly   199 IEYLYQDHTPPNLWKHAPIVDPHNPYDQDEKKQYKMFTYHVEHRYNTLL-----PDIPFERLNLI 258
            ||..|:.       |...:..|       .:..:|:....:......:|     ||:    :..:
 Worm   165 IESQYER-------KSCLVAKP-------TQFMFKLNYGQLNRTDEQILNAKSRPDV----IGKV 211

  Fly   259 KEY-VHTNQV-NTTEILNEHMTTKEYLDEYI------ALENQMLAARYGAIVTRRRRLVDSARFM 315
            |:: :..::| :..:||..|...:..||::.      ..:|:.|||.:|        :.|    :
 Worm   212 KDFEIKKSKVKHDQQILYSHDCYRGNLDQFTLPGARWMPDNKELAANFG--------VAD----L 264

  Fly   316 EDNLD-EGLAKKMC-----MDKNLPMDTNETV-----LIDQSLVDEN--------SRSLTTAEST 361
            |..|| |...:|:.     .|   |:...|.|     .|:|..|.:|        ||::|.|..|
 Worm   265 EVELDLEQEHEKISAYGPFKD---PLSGREVVPPPRWFIEQEAVRQNQEIQSRATSRAITIAAKT 326

  Fly   362 MGISQ---AENSTLKSSEVEATLSVSHIENSLSDSQ---EENPP-------LSSTLAINESSVLD 413
            :..||   ::.:.|....||.....:|:.:.||..:   .:|.|       |......|..||:.
 Worm   327 LRDSQGFGSQPTRLSQPFVERHRQSNHLNDFLSFVEGRVNKNRPSTHLTTGLVDMFVDNFGSVMQ 391

  Fly   414 STRVDPIKDLTLDELLLIDSGISMEELSDIQMHTAGQSFDDEGVVLSDLEDQ---RQLSPMLQMV 475
            :.  :|......||                  :.|...|||:.....|.:|.   |.||...:..
 Worm   392 ND--EPNTSRRPDE------------------NYAPMDFDDDFGGGGDDDDDDYIRNLSRRDEKR 436

  Fly   476 SPSM--EAKTLNIIEMDADLIMNVPREVSYPILLNVMGLPIKRLRRKCIFKLPPEFDLFRQARLP 538
            :|:.  |....:||....|  .|:|          |:..|:|::.:   |:..|...|.|:.|
 Worm   437 APAPWDELDKNHIIWYTGD--ENLP----------VVSKPVKKITK---FQPKPAEMLARKQR-- 484

  Fly   539 IKREGQQKSPTTPRTVLQIGREAPQNEREPGSPCSLEFDEDLNFL-------GFRQRRPTFDSGF 596
             :.|...||                 .|:       ||.|..::|       ...:..|..|  :
 Worm   485 -REEKINKS-----------------RRD-------EFMETHDYLQDYYYWRSAARINPIKD--W 522

  Fly   597 DIEEPRVSSCVSTIGEVKTELEDEIEANTNNLTDASAS--------DALNENVNDTKESGLG--- 650
            .||..|.:........:|.:.....||...|:.....:        :.:.|::..:....||
 Worm   523 KIESLRTAILAEKKRRIKEKTAKIREARIQNMQRKRTARVIPVEQFEPVTEDIPTSNRRTLGAEY 587

  Fly   651 -----DSLAQELNAS------------TEPNAENNTANSSQLEVTATESSGTLSGLETTVDL--- 695
                 :.||.|:..|            ..|..|......:.||..|         |:|..|:
 Worm   588 DDVVDEDLAAEVELSMFGGGFDDDEEDVRPRGERPPMAPNNLEFDA---------LQTDFDIPPA 643

  Fly   696 --------GMESALVSSVLDLSTEPSAMDSNIINVTQPDNSDLEISTVQDQDTLHDEADANDLSA 752
                    .::.|.::||::|                |.|..::.:....:....:..|...::.
 Worm   644 EYVPLRFEDIDDAELNSVINL----------------PGNLLIDKALPLLKKFAENRTDREQMAY 692

  Fly   753 ETPNPIADSAVDDCSL---IRDWHRRLAPALEAAHERQNFNIKDLGTEILDICKAGNRTATLADV 814
            |......|..|...:|   :..||.|:.|.||....|:.:::..:|..::........|..|.|:
 Worm   693 EMAKAYEDVDVAVSTLQEHVDKWHSRMEPILEEGETRKEYDVHAVGRAVIGQYDIEGGTKRLLDL 757

  Fly   815 MADKDPSIMCRYMLASLVLTNHGNV------SLDFENRDKSKPIDMSQFRMHLKSMK 865
            :.|:....:.||.|:.|.:.|.|||      .|..|.|..|..|.:.:..||.:..|
 Worm   758 VMDRPWYEISRYFLSCLFMCNVGNVMVSEDMELPLEERINSMKITLLKRDMHCEMFK 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cap-H2	NP_650014.2	CNDH2_C	<769..862	CDD:465283	27/98 (28%)
kle-2	NP_498727.2	CNDH2_N	17..>107	CDD:461866	18/98 (18%)
		CNDH2_C	582..806	CDD:465283	50/248 (20%)