Protein Alignment hth and meis3

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_571853.1
• Gene: meis3 / 81885
• ZFINID: ZDB-GENE-010406-2
• Length: 415
• Species: Danio rerio
• Alignment Length: 455
• Identity: 205/455 - (45%)
• Similarity: 254/455 - (55%)
• Gaps: 121/455 - (26%)

  Fly    73 SHVSPVGNH--LMGAIPEVH---------KRDKDAIYEHPLFPLLALIFEKCELATCTPRE---- 122
            |...|||.:  .|.::|..|         |..:|.||.|||||||||:|||||||||:||:
Zfish    14 SDAMPVGGYRDTMRSLPPPHYGHTVPDSLKHHRDQIYGHPLFPLLALVFEKCELATCSPRDSTSM 78

  Fly   123 ------PGVQG-GDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEK 180
                  ||:.. .|||||:|||:|||.|:|||||:||.::::||:|:||:|||||||||||||||
Zfish    79 SNPAHLPGMTNHSDVCSSDSFNDDIAAFAKQIRSEKPIFSSNPELDNLMIQAIQVLRFHLLELEK 143

  Fly   181 VHELCDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPP 245
            ||:||||||||||:|||||||.|||:::|             ||.|.:|....|...::
Zfish   144 VHDLCDNFCHRYITCLKGKMPTDLVLEDR-------------EGGSKSDMEDFTGSCTS------ 189

  Fly   246 SSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSP 310
                                     ||:|..:. ..|||.                 |   .|:|
Zfish   190 -------------------------LSEQNQSW-LRDPDD-----------------C---VSTP 208

  Fly   311 ADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKV 375
            :...:|        |..|.|......|.:||..:.|:.| ..|||||:....::|.|||||||||
Zfish   209 SGTPSA--------SCGLNSHSVENCSDAGDGLDGSVAS-PSTGEEDESDRDRRNNKKRGIFPKV 264

  Fly   376 ATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR----AVY 436
            ||||:||||||||:||||||:|||||:||||||||||||||||||||||||||||:||    |.|
Zfish   265 ATNIMRAWLFQHLSHPYPSEEQKKQLSQDTGLTILQVNNWFINARRRIVQPMIDQTNRSGQSAPY 329

  Fly   437 TPHPGPSGYGHDAMGYMMDSQAHMMHRPPGDPGF-------------HQGYPHYPPA--EYYGQH 486
            :|.....|      ||.:|:|:|:..|..|..|.             ..||.|..|:  .|.|.|
Zfish   330 SPEGAALG------GYGLDAQSHLGLRTAGLQGLPSLPTDYPGALLPQPGYSHAGPSLHPYPGPH 388

  Fly   487  486
            Zfish   389  388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	62/84 (74%)
		Homeobox_KN	384..422	CDD:428673	34/37 (92%)
meis3	NP_571853.1	Meis_PKNOX_N	91..174	CDD:465140	62/95 (65%)
		Homeobox_KN	273..311	CDD:428673	34/37 (92%)