Protein Alignment hth and MEIS3

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: XP_024307380.1
• Gene: MEIS3 / 56917
• HGNCID: 29537
• Length: 509
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 218/553 - (39%)
• Similarity: 263/553 - (47%)
• Gaps: 214/553 - (38%)

  Fly     4 PRYDDGLHGYGMDSGAAAAAMY--------DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMH 60
            |:||:..|..|:..|.||.|.:        .|:..||||  |.||
Human    91 PQYDELPHYPGIVDGPAALASFPETVPAVPGPYGPHRPP--QPLP-------------------- 133

  Fly    61 GYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPRE--- 122
               .|....|.                   ||:||.||.|||||||||:|||||||||:||:
Human   134 ---PGLDSDGL-------------------KREKDEIYGHPLFPLLALVFEKCELATCSPRDGAG 176

  Fly   123 PGV---QGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHEL 184
            .|:   .|||||||:|||||||.|:||:||::|.::::||:|:||:|||||||||||||||||:|
Human   177 AGLGTPPGGDVCSSDSFNEDIAAFAKQVRSERPLFSSNPELDNLMIQAIQVLRFHLLELEKVHDL 241

  Fly   185 CDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSL 249
            |||||||||:||||||||||||::||
Human   242 CDNFCHRYITCLKGKMPIDLVIEDRD--------------------------------------- 267

  Fly   250 SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADAR 314
              ||...|              .:..||...|.||             .:..|.|....|
Human   268 --GGCRED--------------FEDYPASCPSLPD-------------QNNMWIRDHEDS----- 298

  Fly   315 NADASRRLYSSVFLGSP------------DNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQK 367
                     .||.||:|            ||  :|..||..:.|:.|....||::|....::..|
Human   299 ---------GSVHLGTPGPSSGGLASQSGDN--SSDQGDGLDTSVASPSSGGEDEDLDQERRRNK 352

  Fly   368 KRGIFPKVATNILRAWLFQHLT------------------------------------------- 389
            ||||||||||||:||||||||:
Human   353 KRGIFPKVATNIMRAWLFQHLSRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCW 417

  Fly   390 ---HPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR----AVYTPHPGPSGYGH 447
               ||||||:|||||||||||||||||||||||||||||||||||||    |.::|...|.|
Human   418 WLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAFSPEGQPIG--- 479

  Fly   448 DAMGYMMDSQAHMMHRPPGDPGFH---QGYPHY 477
               || .::|.|:..||||..|..   :|..||
Human   480 ---GY-TETQPHVAVRPPGSVGMSLNLEGEWHY 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	65/83 (78%)
		Homeobox_KN	384..422	CDD:428673	35/83 (42%)
MEIS3	XP_024307380.1	Meis_PKNOX_N	184..268	CDD:465140	66/124 (53%)
		Homeobox_KN	419..453	CDD:428673	30/33 (91%)