Protein Alignment hth and MEIS2

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 256/510 - (50%)
• Similarity: 296/510 - (58%)
• Gaps: 128/510 - (25%)

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHS 64
            ||| |||:..|..|||.....|:|| |||| .||     :|..|  |:.|.....||     .|.
Human     1 MAQ-RYDELPHYGGMDGVGVPASMYGDPHA-PRP-----IPPVH--HLNHGPPLHAT-----QHY 51

  Fly    65 GAGGHGTPSHVSPVGNHLMG-AIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGG 128
            ||  |....:|.|..   || |:.:..||||||||.|||||||||:||||||||||||||||.||
Human    52 GA--HAPHPNVMPAS---MGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGG 111

  Fly   129 DVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYI 193
            |||||:|||||||:|:||:|::||.::::||:|:||:||||||||||||||||||||||||||||
Human   112 DVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYI 176

  Fly   194 SCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGAST--PDVRPPSSSLSYGGAMN 256
            |||||||||||||||||           |..:|:.:..|   |:||  .|..|.|      ...:
Human   177 SCLKGKMPIDLVIDERD-----------GSSKSDHEELS---GSSTNLADHNPSS------WRDH 221

  Fly   257 DDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRR 321
            |||.|..:..||||.|                                          ...||:
Human   222 DDATSTHSAGTPGPSS------------------------------------------GGHASQ- 243

  Fly   322 LYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQ 386
                    |.||  :|..||..:.|:.| .|||::||....||.||||||||||||||:||||||
Human   244 --------SGDN--SSEQGDGLDNSVAS-PGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQ 297

  Fly   387 HLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR------------AVYTPH 439
            |||||||||:|||||||||||||||||||||||||||||||||||||            |.|:|.
Human   298 HLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPE 362

  Fly   440 PGPSGYGHDAMGYMMDSQAHMMHRP------PGD-------PGFHQGYPHYPPAE 481
            ..|.|      .:::|.|.||..||      |||       .|.....|.|.|.:
Human   363 GQPMG------SFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQ 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	69/83 (83%)
		Homeobox_KN	384..422	CDD:428673	36/37 (97%)
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		99/119 (83%)
		Meis_PKNOX_N	110..194	CDD:465140	70/94 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		41/163 (25%)
		Homeobox_KN	295..333	CDD:428673	36/37 (97%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		32/33 (97%)
		Transcriptional activation domain	340..477		23/78 (29%)