Protein Alignment hth and MEIS1

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_002389.1
• Gene: MEIS1 / 4211
• HGNCID: 7000
• Length: 390
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 252/499 - (50%)
• Similarity: 285/499 - (57%)
• Gaps: 132/499 - (26%)

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHA----------GHRPPGLQGLPSHHSPHMTHAAAAA 54
            ||| ||||..|..|||.....:.|| ||||          .|.||    |.||..||..|..|.|
Human     1 MAQ-RYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP----LHSHQYPHTAHTNAMA 60

  Fly    55 ATVGMHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCT 119
            .::|                         .::.:..||||||||.||||||||||||||||||||
Human    61 PSMG-------------------------SSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCT 100

  Fly   120 PREPGVQGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHEL 184
            ||||||.|||||||||||||||:|:||||::||.::::||:|:||:|||||||||||||||||||
Human   101 PREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHEL 165

  Fly   185 CDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSL 249
            |||||||||||||||||||||||:|             ||.|.:||...|..|:..|  .||.:.
Human   166 CDNFCHRYISCLKGKMPIDLVIDDR-------------EGGSKSDSEDITRSANLTD--QPSWNR 215

  Fly   250 SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADAR 314
            .:     ||..|..:|.||||.|            |...|.
Human   216 DH-----DDTASTRSGGTPGPSS------------GGHTSH------------------------ 239

  Fly   315 NADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNI 379
                           |.||  :|..||..:.|:.| ..||::||....||..|||||||||||||
Human   240 ---------------SGDN--SSEQGDGLDNSVAS-PSTGDDDDPDKDKKRHKKRGIFPKVATNI 286

  Fly   380 LRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAV-----YTPH 439
            :|||||||||||||||:|||||||||||||||||||||||||||||||||||||||     |.|.
Human   287 MRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPD 351

  Fly   440 PGPSGYGHDAMGYMMDSQAHMMHRPPG---DPGFHQGYP---HY 477
            ..|.|      |::||.|.||..|.||   ..|.:.|..   ||
Human   352 GQPMG------GFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHY 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	70/83 (84%)
		Homeobox_KN	384..422	CDD:428673	36/37 (97%)
MEIS1	NP_002389.1	Meis_PKNOX_N	108..192	CDD:465140	70/96 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..279		40/162 (25%)
		Homeobox_KN	291..329	CDD:428673	36/37 (97%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|PubMed:28473536	299..329		28/29 (97%)
		Required for transcriptional activation. /evidence=ECO:0000250	335..390		25/61 (41%)