Protein Alignment Cyp12e1 and cyp27a1.2

DIOPT Version :10

• Sequence 1: NP_650003.4
• Gene: Cyp12e1 / 41272
• FlyBaseID: FBgn0037817
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_073769098.1
• Gene: cyp27a1.2 / 795106
• ZFINID: ZDB-GENE-081104-511
• Length: 580
• Species: Danio rerio
• Alignment Length: 517
• Identity: 140/517 - (27%)
• Similarity: 242/517 - (46%)
• Gaps: 76/517 - (14%)

  Fly    21 RGLAQKATAVNL------EEAKPYADIPGPSKLQLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIF 79
            |..|..|.|.::      .:.|..||:|......::...|..| |.| .|||:.|...:.||.::
Zfish    95 RSAAGNAAAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG-YLN-SVHELQLYQKQVYGPLW 157

  Fly    80 RMP-------SVAGTDLVLTMNPQDYEVIFRNEGQYPYR---------RSFEVMDYFKRVHRREV 128
            ::.       |::..:|:        |.:.|.:.:||.|         |....:.|
Zfish   158 KINAGNLQGISISSVELL--------EELLRKDEKYPCRGYMTLWTEHRDLRGISY--------- 205

  Fly   129 FDGYDGLTSGNGPAWGKMRTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRD-PVTQEMPDD 192
                 |..:..|..|.|:|..:|..:|.|:::..|...:..|..:|::||..:|: ..|.::..:
Zfish   206 -----GPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSN 265

  Fly   193 FAVDIRHLVIESICSVALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMPAFW--KYLPM 255
            ...::....:|.|.|:...|.:|.| |:....:.||.:..:..:......:.::|. |  ||.|.
Zfish   266 LTNELYRFSLEGIASILFETRIGCL-EKEIPAETQKFINFIAQMFTYSMHVALLPN-WTRKYFPF 328

  Fly   256 PNFKKLMRSLDTITDFCYFHIGNALKRIEEDAKAGTLNEIGLE--TSLLE--KLARFDRQTAVII 316
              ::|.:...|.|..|....|...::.|::  :..|..::..|  |.||.  |::|.|...:|
Zfish   329 --WQKYIDGWDGIFKFGTKMIDMKMEAIQK--RVDTNQDVAGEYLTYLLSNGKISRKDVYGSV-- 387

  Fly   317 AMDLLFAGADPTLVTLGGILFSLSKSPDKQARLLEEIRGILPNKDSSL-TIENMRNLPYLRACIK 380
             .:||.||.|.|..|:...|:.|||.|:.|..|.:|:..:|  ||..: |.|.:.::|:|:|.||
Zfish   388 -SELLLAGVDSTSNTMLWALYLLSKDPEAQETLYQEVTKVL--KDDRIPTAEEVNSMPFLKAVIK 449

  Fly   381 EGIRMYPIGPGTLRRMPH-DVVLSGYRVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDES 444
            |.:|:||:.|...|.:.. :||:..|.....|...: .:|.::..|:..|:.::|.|||||||
Zfish   450 ETLRLYPVVPVNSRLIAETEVVIGEYFFPKKTTFTL-CHYVISRDEKVFPEPQKFKPERWLRD-- 511

  Fly   445 NSHLVGET-ATPFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAFKAQF 505
                 |.| ..||..:|||||.|:|.|:||.::.:.:|::||::.|::..| |.....||.|
Zfish   512 -----GRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPD-PTVGEVKANF 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	CYP24A1-like	73..514	CDD:410677	124/459 (27%)
cyp27a1.2	XP_073769098.1	None