Protein Alignment Cyp12e1 and Cyp11b2

DIOPT Version :10

• Sequence 1: NP_650003.4
• Gene: Cyp12e1 / 41272
• FlyBaseID: FBgn0037817
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_036670.2
• Gene: Cyp11b2 / 24294
• RGDID: 2454
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 134/543 - (24%)
• Similarity: 233/543 - (42%)
• Gaps: 94/543 - (17%)

  Fly     2 LSTQWNANKQISRQIYQLCRGLAQKATAVNLEEAKPYADIPGPSK------LQLIRAFLPGGLYK 60
            |:..|        |.....|.|...||... :..||:..||..|:      :|::|.  .|....
  Rat    13 LARPW--------QCLHRTRALGTTATLAP-KTLKPFEAIPQYSRNKWLKMIQILRE--QGQENL 66

  Fly    61 NLPVHEMFLDMNRQYGSIFRMPSVAGTDLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHR 125
            :|.:|:.|    ::.|.||| .|..|..:|..|.|:|.|.:.:.|...|.|...|..     |..
  Rat    67 HLEMHQAF----QELGPIFR-HSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPW-----VAH 121

  Fly   126 REVFDGYDGLTSG----NGPAWGKMRTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRDPVT 186
            ||:    .||..|    ||..|...|..:||.:|.|:..:.::..:.:|:.:|||   .::..|.
  Rat   122 REL----RGLRRGVFLLNGADWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLE---ALKKKVR 179

  Fly   187 QEMPDDFAVDIR----HLVIESICSVALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMP 247
            |.......:|::    :..||:.........|||||...|...: |.:.||..:.:...||..:|
  Rat   180 QNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSL-KFIHALHSMFKSTTQLLFLP 243

  Fly   248 -AFWKYLPMPNFKKLMRSLDTITDFCYFHIGNALKRIEEDAKAGTLNEI-GLETSLLEKLARFDR 310
             :..::.....:|:...:.|.|:::.    ...:.::.::.:.|:.... |:..:|:       .
  Rat   244 RSLTRWTSTRVWKEHFDAWDVISEYA----NRCIWKVHQELRLGSSQTYSGIVAALI-------T 297

  Fly   311 QTAVII------AMDLLFAGADPTLVTLGGILFSLSKSPDKQARLLEEI----RGILPNKDSSLT 365
            |.|:.:      :|:|.....|.|.:.|...||.|:::||.|..|.:|.    ..|..|...:
  Rat   298 QGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKA-- 360

  Fly   366 IENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVLSGYRVVAGTDVGIAANYQMANMEQFVPK 430
               |.:||.|||.:||.:|:||:|....|.:..|:||..|.|.|||.| :...|.|.......|:
  Rat   361 ---MSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLV-LLYLYSMGRNPAVFPR 421

  Fly   431 VREFIPERWLRDESNSHLVGETATPFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKIGFDY 495
            ...::|:|||          |....|.:|.||||.|.|.|:|:.::.:.:.:..:::.|::
  Rat   422 PERYMPQRWL----------ERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQV---- 472

  Fly   496 PIENAFKAQFFVQPNIPFKFKFI 518
                    :...|.::...::|:
  Rat   473 --------ETLRQEDVQMAYRFV 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	CYP24A1-like	73..514	CDD:410677	115/460 (25%)
Cyp11b2	NP_036670.2	cytochrome_P450	74..498	CDD:477761	117/471 (25%)