Protein Alignment CG6345 and CDK5RAP1

DIOPT Version :9

• Sequence 1: NP_650002.1
• Gene: CG6345 / 41271
• FlyBaseID: FBgn0037816
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001352657.1
• Gene: CDK5RAP1 / 51654
• HGNCID: 15880
• Length: 601
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 300/554 - (54%)
• Similarity: 391/554 - (70%)
• Gaps: 17/554 - (3%)

  Fly    36 KSEPAARATFLERIQRGPGFQDFFAVKPASRLKTDEEEHVDTSVPYLNSIDFNGNGRKVHFEVYG 100
            :.|..||..|..|:..||.||.|  :|.||..:......|:...|||...:..|..|||:.|.||
Human    46 RQEDGARKDFSSRLAAGPTFQHF--LKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYG 108

  Fly   101 CQMNTNDTEVVFSILKENGYLRCQEPEEADVIMLVTCAVRDGAEQRIRNRLKHLRAMKNKRSTRR 165
            ||||.||||:.:|||:::||||....:|||||:||||::|:.|||.|.|||..|:|:|.:|...|
Human   109 CQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSR 173

  Fly   166 HPLQLTLLGCMAERLKEKLLEQEQCVDVIAGPDSYKDLPRLLAISRHYGNSAINVLLSLDETYAD 230
            .||::.:||||||||||::|.:|:.||::||||:|:|||||||::.. |..|.||||||||||||
Human   174 VPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAES-GQQAANVLLSLDETYAD 237

  Fly   231 VMPVRLNSESPTAFVSIMRGCDNMCTYCIVPFTRGRERSRPLASIVAEVKALAE----------- 284
            ||||:.::.:.:|||||||||||||:|||||||||||||||:|||:.|||.|:|
Human   238 VMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKV 302

  Fly   285 ---QGVKEVTLLGQNVNSYRDRTAQEEQDSLKATPVPGFSTVYKPKTGGTPFAALLRSVAQAVPD 346
               ||:||||||||||||:||.:..:...::......||:|.||.|.||..||.||..|::..|:
Human   303 LGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPE 367

  Fly   347 MRIRFTSPHPKDFSDEVLEVIRDHPNVCKQLHLPAQSGNTQVLERMRRGYSREAYLELVQHIRQF 411
            |||||||||||||.||||::|.:..|:|||:|||||||:::|||.||||||||||:|||.|||:.
Human   368 MRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRES 432

  Fly   412 LPNVGLSSDFICGFCGETEEEFQDTVSLIQQVQYNVAYLFAYSMREKTTAHRRYKDDVPINVKNE 476
            :|.|.||||||.||||||||:...||||:::||||:.:|||||||:||.|:.|.|||||..||..
Human   433 IPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLR 497

  Fly   477 RLQRMVQVFREGATQLHRKMEGQEQLILIEGKSKRSDAHWFGRNDANIKVIVPSIYVPISGDSTA 541
            ||:.::.:|||.||:.::...|..||:|:||.||||.....||||.|:|||.|...:....:...
Human   498 RLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGL 562

  Fly   542 RKSFGVGDFLAVRIEESNSQVLKGTPLELSNITD 575
            |.....||::.|:|..::||.|:|..|..:.:.|
Human   563 RVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRD 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6345	NP_650002.1	PRK14329	88..570	CDD:237676	282/495 (57%)
		UPF0004	93..196	CDD:279287	58/102 (57%)
		TRAM	494..568	CDD:280171	28/73 (38%)
CDK5RAP1	NP_001352657.1	UPF0004	88..588	CDD:332448	284/500 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E1_COG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9502
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1030
Isobase	1	0.950	-	0	Normalized mean entropy	S2963
OMA	1	1.010	-	-		QHG54971
OrthoDB	1	1.010	-	-		D407532at33208
OrthoFinder	1	1.000	-	-		FOG0005052
OrthoInspector	1	1.000	-	-		oto89210
orthoMCL	1	0.900	-	-		OOG6_102063
Panther	1	1.100	-	-	LDO	PTHR43020
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3577
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790