Protein Alignment CG6345 and CDK5RAP1

DIOPT Version :10

• Sequence 1: NP_650002.1
• Gene: CG6345 / 41271
• FlyBaseID: FBgn0037816
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001352657.1
• Gene: CDK5RAP1 / 51654
• HGNCID: 15880
• Length: 601
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 300/554 - (54%)
• Similarity: 391/554 - (70%)
• Gaps: 17/554 - (3%)

  Fly    36 KSEPAARATFLERIQRGPGFQDFFAVKPASRLKTDEEEHVDTSVPYLNSIDFNGNGRKVHFEVYG 100
            :.|..||..|..|:..||.||.|  :|.||..:......|:...|||...:..|..|||:.|.||
Human    46 RQEDGARKDFSSRLAAGPTFQHF--LKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYG 108

  Fly   101 CQMNTNDTEVVFSILKENGYLRCQEPEEADVIMLVTCAVRDGAEQRIRNRLKHLRAMKNKRSTRR 165
            ||||.||||:.:|||:::||||....:|||||:||||::|:.|||.|.|||..|:|:|.:|...|
Human   109 CQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSR 173

  Fly   166 HPLQLTLLGCMAERLKEKLLEQEQCVDVIAGPDSYKDLPRLLAISRHYGNSAINVLLSLDETYAD 230
            .||::.:||||||||||::|.:|:.||::||||:|:|||||||::.. |..|.||||||||||||
Human   174 VPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAES-GQQAANVLLSLDETYAD 237

  Fly   231 VMPVRLNSESPTAFVSIMRGCDNMCTYCIVPFTRGRERSRPLASIVAEVKALAE----------- 284
            ||||:.::.:.:|||||||||||||:|||||||||||||||:|||:.|||.|:|
Human   238 VMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKV 302

  Fly   285 ---QGVKEVTLLGQNVNSYRDRTAQEEQDSLKATPVPGFSTVYKPKTGGTPFAALLRSVAQAVPD 346
               ||:||||||||||||:||.:..:...::......||:|.||.|.||..||.||..|::..|:
Human   303 LGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPE 367

  Fly   347 MRIRFTSPHPKDFSDEVLEVIRDHPNVCKQLHLPAQSGNTQVLERMRRGYSREAYLELVQHIRQF 411
            |||||||||||||.||||::|.:..|:|||:|||||||:::|||.||||||||||:|||.|||:.
Human   368 MRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRES 432

  Fly   412 LPNVGLSSDFICGFCGETEEEFQDTVSLIQQVQYNVAYLFAYSMREKTTAHRRYKDDVPINVKNE 476
            :|.|.||||||.||||||||:...||||:::||||:.:|||||||:||.|:.|.|||||..||..
Human   433 IPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLR 497

  Fly   477 RLQRMVQVFREGATQLHRKMEGQEQLILIEGKSKRSDAHWFGRNDANIKVIVPSIYVPISGDSTA 541
            ||:.::.:|||.||:.::...|..||:|:||.||||.....||||.|:|||.|...:....:...
Human   498 RLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGL 562

  Fly   542 RKSFGVGDFLAVRIEESNSQVLKGTPLELSNITD 575
            |.....||::.|:|..::||.|:|..|..:.:.|
Human   563 RVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRD 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6345	NP_650002.1	MiaB	91..569	CDD:440386	280/491 (57%)
CDK5RAP1	NP_001352657.1	MiaB	100..589	CDD:440386	280/489 (57%)