DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6345 and F25B5.5

DIOPT Version :9

Sequence 1:	NP_650002.1	Gene:	CG6345 / 41271	FlyBaseID:	FBgn0037816	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_498290.1	Gene:	F25B5.5 / 175841	WormBaseID:	WBGene00017776	Length:	547	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	265/541 - (48%)
Similarity:	359/541 - (66%)	Gaps:	48/541 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AVKPASRLKTD------------EEEHVDTSVP-------YLNSIDFNGNGRKVHFEVYGCQMNT 105
            ||||...:.||            :::.....:|       |||..|..||||.|.:..||||||.
Worm    28 AVKPKRAIPTDGLQLSDFIKESTKKQRQKAIIPSIEDTKEYLNPEDLQGNGRTVCYVTYGCQMNV 92

  Fly   106 NDTEVVFSILKENGYLRCQEPEEADVIMLVTCAVRDGAEQRIRNRLKHLRAMKNKRSTRRHPLQL 170
            :|.|:|.||:.:.|::...:.|.||:::|:||::|||||:::.|:||.:|:    .|..:..: :
Worm    93 SDMEIVRSIMTKYGFVESDKKENADIVLLMTCSIRDGAEKKVWNQLKLIRS----NSVNKGQI-V 152

  Fly   171 TLLGCMAERLKEKLLEQEQCVDVIAGPDSYKDLPRLLAISRHYGNSAINVLLSLDETYADVMPVR 235
            .:|||||||::..|||:...|:::||||||:|||||:|::.. |::.|||.||||||||||.|:|
Worm   153 GVLGCMAERVRHDLLEKRNLVNIVAGPDSYRDLPRLVAVAAG-GSNGINVQLSLDETYADVQPIR 216

  Fly   236 LNSESPTAFVSIMRGCDNMCTYCIVPFTRGRERSRPLASIVAEVKALAEQGVKEVTLLGQNVNSY 300
            ::|.|.|||:|||||||||||||:||||||||||||:.|||.||:.|.:||.|:|||||||||||
Worm   217 VDSASKTAFISIMRGCDNMCTYCVVPFTRGRERSRPIESIVEEVQRLRDQGYKQVTLLGQNVNSY 281

  Fly   301 RDRTAQE--------EQDSLKATPVPGFSTVYKPKTGGTPFAALLRSVAQAVPDMRIRFTSPHPK 357
            ||.|:.:        ::|.     ||||.||||||:||..|..||..||.|.||:|.||||||||
Worm   282 RDMTSMDFSMAPSTSQEDR-----VPGFKTVYKPKSGGLTFTTLLEKVADAAPDIRFRFTSPHPK 341

  Fly   358 DFSDEVLEVIRDHPNVCKQLHLPAQSGNTQVLERMRRGYSREAYLELVQHIRQFLPNVGLSSDFI 422
            ||..:::|:|...||:|||||||||||:.:.||||.|||:|:.||.||..||..||:|.|:||||
Worm   342 DFPMQLIELIASRPNLCKQLHLPAQSGDDETLERMERGYTRDLYLRLVDDIRHVLPSVSLTSDFI 406

  Fly   423 CGFCGETEEEFQDTVSLIQQVQYNVAYLFAYSMREKTTAHRRYKDDVPINVKNERLQRMVQVFRE 487
            .|||||||:..|:|:|||:.|:|:..::|.||||.||.||.|..||||.:||..|...:..||||
Worm   407 AGFCGETEQAHQNTLSLIRAVRYSFCFVFPYSMRGKTRAHHRLTDDVPEDVKARRHLDLTTVFRE 471

  Fly   488 GATQLHRKMEGQEQLILIEGKSKRSDAHWFGRNDANIKVIVPSIYVPISGDSTARKSFGVGDFLA 552
            .|.:|::.:.|.||.:|:||||||..:...||.|..:|.:.          ..::.....|.:..
Worm   472 EALKLNQALIGSEQTVLLEGKSKRDASFSHGRIDGGVKAVF----------DNSKLCLEPGQYAK 526

  Fly   553 VRIEESNSQVLKGTPLELSNI 573
            :.|.::|||.||...:..|:|
Worm   527 ILITDANSQTLKAQLIGQSSI 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6345	NP_650002.1	PRK14329	88..570	CDD:237676	252/489 (52%)
		UPF0004	93..196	CDD:279287	40/102 (39%)
		TRAM	494..568	CDD:280171	21/73 (29%)
F25B5.5	NP_498290.1	PRK14329	62..544	CDD:237676	256/502 (51%)
		UPF0004	80..178	CDD:279287	40/102 (39%)
		TRAM	478..542	CDD:280171	21/73 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159633
Domainoid	1	1.000	267	1.000	Domainoid score	I999
eggNOG	1	0.900	-	-		E1_COG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9502
Inparanoid	1	1.050	505	1.000	Inparanoid score	I731
Isobase	1	0.950	-	0	Normalized mean entropy	S2963
OMA	1	1.010	-	-		QHG54971
OrthoDB	1	1.010	-	-		D407532at33208
OrthoFinder	1	1.000	-	-		FOG0005052
OrthoInspector	1	1.000	-	-		oto17625
orthoMCL	1	0.900	-	-		OOG6_102063
Panther	1	1.100	-	-	LDO	PTHR43020
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2454
SonicParanoid	1	1.000	-	-		X3577
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790